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  • PHARMACODYNAMIC INTERACTION OF FENUGREEK LEAVES EXTRACT WITH FLUVASTATIN IN DIABETES INDUCED VASCULAR DYSFUNCTION

    About Authors:
    ATUL KABRA* , PREMAL KAPADIA
    Department of Pharmacology,
    G.H.B Pharmacy college,
    Aniyad, Gujarat

    * atul.kbr@gmail.com

    ABSTRACT:
    The cardiovascular risk factors were significantly abnormally altered in diabetic rats when compared to normal control. The present study FLEt with low dose of OHA’s indicates the significant improvement in endothelial dependent vasodilatation because the percentage relaxation produced by acetylcholine was more significant when these groups were compared with diabetic control.However all the treated groups restored these changes significantly to normal conditions in diabetic rats when compared to diabetic control. The combined therapy of FLEt and Fluvastatin was found to be significantly effective. Moreover, this combination was also found to demonstrate synergistic behavior than pioglitazone plus fluvastatin.
    We conclude that of preventive therapy with combination of FLEt with OHA’s (low dose) may prevent the endothelial dysfunction in diabetic patients (prediabetic state) due to free radical scavenging activity, metabolic control.

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  • Sorbead India invites B.Pharm, B.Sc fresher or experience to work as Business Development Manager / Executive, Product Managers - 8 posts

    Sorbead India is an ISO 9001 accredited fast growing organization engaged in manufacturing & exports of "Adsorbents & Desiccants" The company is in explosive growth phase and is looking for personnel for its various divisions. We are looking for dynamic & result oriented achievers who have abilities to take challenges. Following are recent openings for our Vadodara Office:

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  • Applications are invited from CSIR-UGC JRF/ ICMR-JRF/ DBT-JRF/ DST inspired fellows for position of JRF in Immunology

    Applications are invited from CSIR-UGC JRF/ ICMR-JRF/ DBT-JRF/ DST inspired fellows for position of JRF in Immunology

    Post: JRF in Immunology

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  • Require M.Sc./M.Pharm for Stem Cell Research at Department of Cell and Molecular Biology, B. V. Patel PERD Centre

    In October 1990 the B. V. Patel Education Trust in conjuncture with the Indian Pharmaceutical Association established B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, in the memory of late Mr. B. V. Patel, the first Drug Controller of Gujarat.

  • EVALUATION OF ANTIULCER ACTIVITY OF FRUIT EXTRACT OF Ziziphus jujuba IN RATS

    About Author:
    ATUL KABRA*, NITIN PATEL
    Department of Pharmacology
    G.H.B Pharmacy college,
    Aniyad, Gujarat

    * atul.kbr@gmail.com

    ABSTRACT:
    The antiulcer effect of aqueous fruit extract of Zizizphus jujuba was studied in ethanol induced ulcer model in rats. The extract dose of 50 mg/kg, 100mg/kg, 200 mg/kgproduced significant inhibition of gastric lesion induced by ethanol. The extarct reduced ulcerative lesion, gastric volume, total acidityin ethanol induced ulcer model.The result obtained suggesting that extract possesses significant antiulcer activity. 

  • Juggat Pharma invites for various positions in all major cities of Gujarat, Rajasthan & Madhya Pradesh

    Juggat Pharma, Pharmaceutical Division of Jagdale Industries Limited is one of the fastest growing and high performing pharmaceutical marketing company with a global presence based at Bangalore, Karnataka. We provide an ideal environment for highly qualified and committed professionals to pursue their career Under the expansion plan, we are looking for 'Marketing Professionals' in Gujarat/Rajasthan/Madhya Pradesh.

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  • Synthesis and Antimicrobial activity of Bulky molecules comprising Benzothiazole and Sulphonamide moieties

    About Authors:
    Pritesh R. Patel*, Priyank Patel, Jagath Pillai, Nilesh Darji, Bhagirath Patel
    Department of Pharmaceutical Chemistry,
    Sat Kaival College of Pharmacy, Sarsa,
    Ta & Dist: Anand (Gujarat), India-388365

    *prit.pharma@gmail.com

    ABSTRACT
    As part of ongoing studies in developing new antimicrobials, a novel series of 4-acetamido-N-(substituted 1, 3-benzothiazol-2-yl) benzenesulphonamide and N-(substituted 1, 3-benzothiazol-2-yl)-4-(substituted aryl diazenyl) benzenesulphonamide were synthesized in order to determine their antibacterial and antifungal activity. The synthesized compounds were tested in vitro against two Gram-positive bacteria like Staphylococcus aureus, Bacillus subtilis; two Gram-negative bacteria like Escherichia coli, Pseudomonas aeruginosaand one fungal strain Candida albicans in comparison with standard drugs. Microbiological results showed that the synthesized compounds possessed a broad spectrum of antibacterial and antifungal activity against the tested microorganisms. The compounds with a 6-chloro (SK5b), 7-chloro-6-fluoro(SK5d) and 6-nitro (SK5e) on 2-amino benzothiazole ring possessing azo linkage showed better antimicrobial activity; almost similar or less to that of standard drugs thus they could be promising candidates for novel drugs. The novel heterocyclic derivatives were characterized by Physical characterization (Melting point, TLC) and different Spectroscopy techniques (IR, 1H NMR and Mass spectroscopy).

  • Walk in Interview for R&D, QA-Executives, Manufacturing in Atul Limited

    Atul Ltd is a member of Lalbhai Group, one of the oldest business houses of India, with interests mainly in textiles and chemicals. The Group is strongly committed to serve the society in the fields of education, health as well as culture.

  • BULLOUS PEMPHIGOID

    About Authors:
    Patel Punita s*, Patel Brilina M, Arora Bhoomi
    Institute of clinical research India
    ahmedabad, Gujarat
    *
    punitapatel_icri@ymail.com

    Abstract:
    Bullous Pemphigoid (BP) is an autoimmune subepidermal blistering disease appearing predominantly in the elderly. Bullous Pemphigoidcharacterized by an autoimmune response to 2 hemidesmosomal proteins within the dermal–epidermal junction, These proteins, called BP antigen 1 (BPAG1 or AgBP230), and BPAG2 (or AgBP180 or collagen XVII) have respective molecular masses of 230 and 180. While BP180 is a transmembrane glycoprotein with an extracellular domain BP230 localizes intracellularly and associates with the hemidesmosomal plaque. The disease is characterized clinically by tight bullae, with clear content, often large, developing primarily on the edge of erythematous plaques. Intense itching is common. The disease is primarily treated with systemic corticosteroids. Now,The increased knowledge of the development of noveltherapeutic strategies for Bullous Pemphigoids.

  • Opening for JRF in INDIAN INSTITUTE OF ADVANCED RESEARCH

    Applications are invited from CSIR-UGC JRF/ ICMR-JRF/ DBT-JRF/ DST inspired fellows for position of JRF in Immunology

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