• 12 March 2013

    SPECTROPHOTOMETRIC ESTIMATION OF TOLPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN SYNTHETIC MIXTURE BY DUAL WAVELENGTH METHOD

    ABOUT AUTHORS:
    Hiral H. Patel*, Paresh U. Patel,
    Department of Pharmaceutical Analysis, Center for Health and Science Studies,
    Ganpat University, Ganpat Vidyanagar – 384012,
    Mehsana, Gujarat, India.
    *patel.hiral2210@gmail.com

    ABSTRACT
    This method describes simple, sensitive, rapid, accurate, precise and economical derivative spectroscopic methodfor the simultaneous determination of tolperisone hydrochloride (TOL) and diclofenac sodium (DIC) in bulk and synthetic mixture. In this study, dual wavelength spectroscopic method was used for simultaneous determination of tolperisone hydrochloride and diclofenac sodium using the absorbance difference at two wavelengths. The absorbance differences of 257 nm and 306.20 nm were selected for the estimation of TOL and the absorbance differences of 243.40 nm and 265.40 nm were selected for estimation of DIC. The method was found to be linear (r2>0.999) in the range of 2- 18 μg/ml for tolperisone hydrochloride. The linear correlation was obtained (r2>0.997) in the range of 2- 18 μg/ml for diclofenac sodium. The limit of determination was 0.66 and 0.27 μg/ml for tolperisone hydrochloride and diclofenac sodium respectively. The limit of quantification was 2.00 and 0.83 μg/ml. The method was successfully applied for simultaneous determination of tolperisone hydrochloride and diclofenac sodium in binary mixture.

  • 7 March 2013
    Require Professor, Associate Professor, Assistant Professor for Pharmaceutical Technology @ SRICT

    SRICT is about finding solutions to social exclusion and disintegration and will look to work with private, public and third sector partners in stimulating cohesion, entrepreneurship, economic development and involvement in neighborhood renewal and regeneration within community of chemical industries at Ankleshwar. The basic academic philosophy of the Shroff S.R.

  • 5 March 2013
    Require more than 200 MEDICAL REPRESENTATIVES in different locations of India

    We are 5th largest pharma co. of India and going to launch OPHTHALMIC DIVISION at India level and we require more than 200 MEDICAL REPRESENTATIVES in different locations of India.

    Post: Medical Representative [ Ophthalmic division ]

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  • 27 February 2013
    Walk in interview for the Post of Pharmacist in Western Railway- 3 Posts

    Western Railway Rajkot Division has issued notification and invites qualified candidates for walk in interview for total 10 posts of full time Para- Medical staff in Medical department purely on contract base. Interested and eligible candidates may walk for interview along with necessary documents. The details of the posts such as educational qualification, application format, posting place and other details are given below.

  • 27 February 2013
    Application invited for post of Pharmacist in Shri Vinoba Bhave Civil Hospital

    Shri Vinoba Bhave Civil Hospital, Silvassa invites applications for below mentioned posts to be filled on short term contract basis so as to reach the undersigned on or before 28/02/2013.

    Post: Pharmacist- Group- C

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  • 26 February 2013
    Opening for Junior Research Fellow in Indian Institute of Advanced Research | Walk in

    Walk–in-interview on 6th March, 2013 for post of JRF under the project “To study the role of Histidine residue(s) in functioning of Arabidopsis cation/H+ Exchanger CAX3 funded by GSBTM, Govt. of Gujarat.

    Post: Junior Research Fellow

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  • 22 February 2013
    AICTE SPONSORED Two Weeks Faculty Development Programme on “Recent Advances in Parentral Drug Delivery Systems & Technology” @ Ganpat University

  • 14 February 2013
    Work as Senior Executive projects in Reputed Pharma MNC

    Global generic pharmaceuticals leader and one of the top 15 pharmaceutical companies in the world. Headquartered in Israel,operates in 60 countries and has 46,000 employees worldwide. Established in 1901, takes great pride in its long tradition of leadership and dedication to excellence.

    Post: Senior Executive projects

  • 12 February 2013
    Opportunity for Assistant Manager-Projects (Brownfield) in Global generic pharmaceuticals

    Global generic pharmaceuticals leader and one of the top 15 pharmaceutical companies in the world. Headquartered in Israel, operates in 60 countries and has 46,000 employees worldwide. Established in 1901

    Post: Assistant Manager-Projects (Brownfield)

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  • 30 January 2013
    INSIGNIFICANT EFFECT OF SUPERPOROUS HYDROGEL PARTICLES AS A SUPERDISINTEGRANTS IN FAST DISPERSIBLE TABLETS OF ACECLOFENAC

    About Authors:
    Dr. HV Chavda1*, Ms. SK Patel1,     Dr. CN Patel1,
    1Shri Sarvajanik Pharmacy College,
    Nr. Arvind Baug, Mehsana, Gujarat-384001, India.
    *hvchavda@sspcmsn.org

    ABSTRACT
    Background:     In present investigation an attempt has been made to formulate a fast dispersible formulation of aceclofenac using three different superdisintegrants. The role of superporous hydrogel particle as a superdisintegrant was checked for its further future applications. Materials and Methods: The selection of superdisintegrants viz. poly (Acrylamide-co-Acrylic acid) superporous hydrogel particles, cross carmellose sodium and starch 1500 were done using the simplex lattice design. Tablet formulations were prepared using direct compression technique and evaluated for hardness, weight variation, friability, drug content, dispersion time, wetting time, water absorption ratio and in vitro drug release studies. Results and Discussion: The dispersion time of all formulation showed less than 21 second. Superporous hydrogel particles did not showed significant improvement in dispersion time compared cross carmellose sodium and starch 1500. The in vitro drug release from batch F7, tablets containing equal proportions of superdisintegrants showed fast dispersion and fast release compared to other batches. Batch F7 was stable for the period of six months at 40 oC / 75 %RH. Conclusions: Combination of three superdisintegrants was more suitable in fast dispersible tablet formulation of aceclofenac. The superporous hydrogel particles showed equivalent effect as a superdisintegrant, however process complexity of its preparation suspects its role or an option as a superdisintegrant in fast dispersible or immediate release formulations.

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