Gujarat

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ABOUT AUTHORS
JA Sathwara^1*, AM Bhandari^2
1Department of Pharmacology,
A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, V.V. Nagar, Anand, Gujarat.
²Department of Clinical Pharmacy,
A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, V.V. Nagar, Anand, Gujarat.
*jignasa.sathwara@gmail.com

ABSTRACT
The aim of the present study was to investigate antiepileptic effect of the aqueous extract of the leaves of Murraya koenigii L. Spreng (AEMK) on electrically and chemically induced seizures. The aqueous extract of the leaves of M. koenigii (200 and 300 mg/kg) were studied for its antiepileptic effect on maximal electroshock induced seizures and pentylenetetrazole induced seizures in mice. AEMK (200 and 300 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES) as well as protected animals from pentylenetetrazole induced tonic seizures. The results suggest that the aqeous extract of the leaves of M. koenigii may produce its antiepileptic effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole.

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