Gujarat

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ABOUT AUTHORS
Suleman S. khoja, Parthkumar H. Chauhan, Maulik N. Patel, Harsha D. Jani
Department of Quality Assurance,
Shivam Pharmaceutical Studies and Research Centre, Anand, Gujarat.
premukhoja@gmail.com

ABSTRACT
Cinnarizine and Dimenhydrinate combination are active contain and approved by CDSCO The two substances belong to different groups of medicines. Cinnarizine  is a part of a group called calcium antagonists.  Dimenhydrinate belongs to a group called antihistamines Also used in Treatment of vertigo symptoms of various origins. exhibits  anti-emetic and antivertiginous  effects through  influencing the chemoreceptor trigger zone in  the  region of the  4th  ventricle.  Dimenhydrinate thus  acts  predominantly on the central vestibular system.  Due to  its calcium  antagonistic properties, cinnarizine acts  mainly  as a vestibular sedative  through inhibition  of  the calcium  influx  into  the vestibular  sensory cells. Cinnarizine thus acts predominantly on the peripheral vestibular system. Both  cinnarizine and  dimenhydrinate  are  known  to  be effective in  the treatment  of  vertigo.  The combination product is more effective than the individual compounds in the population studied.  The product has not been evaluated in motion sickness. Maximum plasma  concentrations  (Cmax)  of  cinnarizine  and diphenhydramine are reached in  humans  within  2  - 4 hours. metabolised  in  the liver. Cinnarizine is  mainly eliminated  via the  faeces (40-60%) and to a lower extent also in  urine, mainly in the form  of  metabolites conjugated  with  glucuronic acid.  The major route  of  elimination  of diphenhydramine is in  the urine

Established in 1968, as a registered charitable trust has been constantly striving for the upliftment of rural society through the education. Dedicated industrialist, educationalist and enlightened citizen from Wadhwan city and outside form the team and the core of Management. VBT always stands for national character building and gives full attention to tradition, culture and ideals with full awareness of modern scientific and technical development of this century and our march to the 21st century.

Post: Professor,  Assistant Professor , Associate Professor

CHARUSAT invites applications from competent personnel for following positions to fuel its growth:

Post: Faculty positions

The mission of Shree Swaminarayan Sanskar Pharmacy College, Zundal is to advance the pharmaceutical care not only to the state, country but throughout the global community through teaching, through our research, and through our service. The college will provide high quality education in the field of pharmaceutical sciences through teaching, research, practices, and related service activities including outreach and engagement.

The Indian Council of Agricultural Research (ICAR) is an autonomous organisation under the Department of Agricultural Research and Education (DARE), Ministry of Agriculture, Government of India. Formerly known as Imperial Council of Agricultural Research, it was established on 16 July 1929 as a registered society under the Societies Registration Act, 1860 in pursuance of the report of the Royal Commission on Agriculture. The ICAR has its headquarters at New Delhi.

Post: Field Assistant - 01

The Indian Council of Agricultural Research (ICAR) is an autonomous organisation under the Department of Agricultural Research and Education (DARE), Ministry of Agriculture, Government of India. Formerly known as Imperial Council of Agricultural Research, it was established on 16 July 1929 as a registered society under the Societies Registration Act, 1860 in pursuance of the report of the Royal Commission on Agriculture. The ICAR has its headquarters at New Delhi.

Post: Senior Research Fellow (SRF) - 01

Saurashtra University, Rajkot invites applications for the following temporary positions on contractual basis at the fixed emoluments under Center of Excellence in Drug Discovery at NFDD Complex, Saurashtra University Campus, Rajkot, funded by Industries Commissionerate, Gandhinagar projects sanctioned for the period of 3 years.

Post: Project Fellow