ABOUT AUTHORS: Monika A. Rana*, Hasumati A. Raj
Department of Quality Assurance
Shree Dhanvantary College of Pharmacy,
Kim, Gujarat, India monika92rana@gmail.com
ABSTRACT
Levosulpiride is an atypical antipsychotic agent. Levosulpiride is the levo enantiomer of sulpiride. It is a substitute benzamide which is meant to be used for several indications: depression, psychosis, somatoform disorders, emesis anddyspepsia. It blocks the presynaptic dopaminergic D2 receptor. Chemically it is N-[[(2S)-1-Ethylpyrrolidin-2-yl] methyl]-2-methoxy-5 sulfamoylbenzamide. several method such as HPLC in human plasma, area under curve, stability by RP-HPLC is done. The parent drug is given in a dose of 400-1800 mg orally. According to literature survey study of impurity profiling of LIVOSULPIRIDE in presence of intermediate has not been reported.
ABOUT AUTHORS Grishma Trivedi*, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat *trivedigrishma18@gmail.com
ABSTRACT
Pravastatin is an inhibitor of HMG-CoA reductase inhibitor which is used as a hypolipidemic agent to reduce cholesterol level. Chemically, 9-Fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl disodium phosphate. Pravastatin is a drug of choice for the cardiovascular disease. It reduces the coronary and cerebrovascular morbidity and mortality in middle aged individual. Elevated plasma concentration of C-reactive protein are associated with protein increased cardiovascular disease, long term therapy with pravastatin an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter. This review consist of various analytical methods for the determination of pravastatin in various marketed pharmaceutical formulation of biological fluid. Analytical methods consist of various chromatographic methods, spectrophotometer methods and electrical methods reported for determination of pravastatin.
Gujarat state is one of the highly industrially developed states in the country. Being an industrialized state, migration of laborers from various parts of India is very high. Mobility and migration of people make them more vulnerable, as a result of separation from spouse and release of social sanctions, leading to high-risk sexual practices and consequently they may contract HIV, which in turn is carried to their spouses and to their children. On the one hand, with an increase in urbanization most of the societies are in transition and the young population is under less social restraint. On the other hand, lower literacy level of rural women, especially in the state and local customs & traditions make women more vulnerable to the infection. Large numbers of women suffer from reproductive tract infections (RTIs), which are mainly due to poor sexual hygiene especially during menstruation and sexually transmitted infections from their spouses.
Soranus Lifesciences is an innovative leading, vertically integrated pharmaceutical formulation company that discovers, develops, manufactures and markets a broad range of healthcare products. Headquartered in the city of Ahmedabad in India, The Company has dedicated research and development department well equipped with the latest equipments and supported by a large pool, of scientists who continuously work towards new pharma products. Soranus Lifesciences Reminisces the Soranus of 1st and 2nd century.
ABOUT AUTHORS: Meera V. Lad1*, Vineet Jain2, Hasumati Raj1 1Department of Quality Assurance, 2Department of Pharmacognosy,
Shree Dhanvantary Pharmacy College, Kim, Gujarat meeralad235@gmail.com
ABSTRACT:
Bromhexine HCl (BRH)is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus, chemically named 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl] aniline hydrochloride. Because of its physiological importance, the drug has been quantified by exploiting its chemical and physical properties. Bromhexine is a weak base and its precipitate out at pH value above 6. Bromhexine is a synthetic benzyl amine derivative ofvasicine. The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ionselectiveelectrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatography, electrochemical oxidation at the glassy carbon electrode, liquid chromatography, liquid gas chromatography, GC with mass detection, and voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry.
S R I C T is about finding solutions to social exclusion and disintegration and will look to work with private, public and third sector partners in stimulating cohesion, entrepreneurship, economic development and involvement in neighborhood renewal and regeneration within community of chemical industries at Ankleshwar. The basic academic philosophy of the Shroff S.R. Rotary Institute of Chemical Technology is to focus on Chemical Technology (covering Chemical Engineering and other Chemical Technology Courses) as the Gujarat’s industrial strength lies in these areas besides Chemical Engineering. The other guiding philosophy is to create R & D infrastructure in these areas (including trained manpower) to meet the industrial needs of Gujarat.
ABOUT AUTHORS: Farhana V. Buchiya*, Vineet Jain, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Surat, Gujarat buchiyafarhana22@gmail.com
ABSTRACT:
Cilnidipine is act as a dual blocker by blocking L- type of calcium channel present in vascular smooth muscles and N- type of calcium channel present in sympathetic nerve terminal that supply blood vessels. Cilnidipine used in treatment of mostly in hypertension and various cardiovascular diseases except in Angina. Cilnidipine used alone or in combination. This review covers most recent analytical methods such as various spectroscopic methods, chromatographic methods and other methods for determination of cilnidipine in various pharmaceutical dosage forms and biological matrix were reported.