Gujarat

Vitalysis is one of the fastest growing Export marketing & Strategic Business Consultancy Company with comprehensive HRM solutions provider.   VITALYSIS is a professionally Managed young & dynamic organization With a Pure focus on Pharmaceutical & Healthcare Industry Practices.

Post : Business Development Manager

Vitalysis is one of the fastest growing Export marketing & Strategic Business Consultancy Company with comprehensive HRM solutions provider.   VITALYSIS is a professionally Managed young & dynamic organization With a Pure focus on Pharmaceutical & Healthcare Industry Practices.

Post : Training Manager

Otsuka Pharmaceutical India Private Limited (OPI) is a major player in Infusion Business in India and Emerging Markets. We primarily manufacture & market products across multiple markets and therapeutic segments. To keep pace with our growth plans, we require experienced and highly competent team members in following areas for our manufacturing facility at Ahmedabad, Gujarat.

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry,
Shri Sarvajanik Pharmacy College,
Mehsana, Gujarat, India
dhrubosen69@yahoo.com

ABSTRACT: Our goal is to perform in-vitro biotransformation of Prodrugs of ibuprofen+paracetamol, diclofenac sodium+paracetamol and ibuprofen+diclofenac sodium by acidic and alkaline hydrolysis of both ester (–COO–) and amide (–CONH–) linkages into free drugs and chromatographically separation of their Rt in HPLC. Since both ester (–COO–) and amide (–CONH–) linkages are susceptible for hydrolysis in both acidic pH (gastric pH) and basic pH (intestinal pH) to produce parent drug ibuprofen, diclofenac and paracetamol by biotransformation in in-vivo; so it will be implemented as a Prodrug which can show prolong action on pain and fever after getting release into free parent drug by biotransformation. The HPLC (High Performance Liquid Chromatography) study reports the retention time (Rt) and release kinetics of three Prodrugs by taking HPLC degradation datas of three samples of Prodrugs and individual HPLC datas of parent drugs separately to compare the Rt value of release of three drugs from Prodrugs in both acidic and alkaline pH. Prodrug–A (logP=4.56) releases Ibuprofen & Paracetamol, Prodrug–B (logP=4.90) releases Diclofenac & Paracetamol and Prodrug–C (logP=6.13) releases Ibuprofen & Diclofenac. This is a comparison study of drug release in in-vitro gastric as well as intestinal pH focusing on in-vivo biotransformation.  Keywords: Prodrug-A/Prodrug-B/Prodrug-C, Ibuprofen, Paracetamol, Diclofenac sodium, Molecular weight, logP, UV λmax, IR, Mobile phase, TLC-Rf value, HPLC-Rt value, LOD, LOC

TORREL (Hospital Division) is a member of internationally renowned TORRENT GROUP (India). The Group has been in manufacturing and marketing of pharmaceutical formulations, since last five decades. Torrent Pharmaceuticals Ltd., a flagship company of the group, is one of the leading pharma companies in India.

Post : General Manager (Institutional Sales)

Zydus Hospira Oncology Private Limited (ZHOPL) is a 50%-50% joint venture (JV) company between Zydus Cadila, India and Hospira (a Pfizer company), manufacturing cytotoxic injectable products (Finished Products). With our past success in more than 30 regulatory inspections including USFDA, MHRA, PMDA, Japan etc... we now embark upon a journey of Self Reliant and making ZHOPL, a Centre of Excellence (CoE) for Oncology products.

Post : Executive/Sr. Executive - Quality Control

Claris Lifesciences is an international pharmaceutical company, in the business of manufacturing and marketing sterile parenteral preparations, life saving medicines and hospital products, focusing on delivery systems, for treatment of critical illnesses and diseases.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an 'Institute of National Importance'. It is an autonomous body set up under the aegis of Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India. The Institute is conceived to provide leadership in pharmaceutical sciences and related areas not only within the country, but also to the countries in South East Asia, South Asia and Africa. NIPER is a member of Association of Indian Universities and Association of Commonwealth Universities.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an 'Institute of National Importance'. It is an autonomous body set up under the aegis of Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India. The Institute is conceived to provide leadership in pharmaceutical sciences and related areas not only within the country, but also to the countries in South East Asia, South Asia and Africa. NIPER is a member of Association of Indian Universities and Association of Commonwealth Universities.