SYNTHESIS AND ANTICANCER ACTIVITY OF FLAVONE DERIVATIVES AGAINST ESTROGEN DEPENDENT CANCERS BY RATIONAL APPROCH
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About Authors:
Vanraj Thakor1*, Jalpa Kher2, Fenil Bhayani1, Bhavini Atodaria1, Malleshappa Noolvi1
1Shree Dhanvantary college of pharmacy, Kim, Surat, Gujarat, India.
2Ashok & Rita Patel institute of Biotechnology, New Vallabh Vidyanagar, Gujarat, India
vanraj7777@gmail.com, jkher3333@gmail.com
Abstract
Aromatase and 17-ßHSD inhibitors are main target of pharmacological interest for the treatment of estrogen dependent cancers. Chalcones, Coumarins, Flavones, Isoflavones have been reported for such inhibition and are used for treatment of breast tumors. So in this topic, Flavone derivatives containing Imidathiadiazole, Thiadiazole, Triazole and benzimidazole hetrocycles synthesised by using simple laboratory reagents like 2-Hydroxy Acetophenone and 4-Hydroxy Benzaldehyde to convert chalcone leads to formation of Flavones by cyclazation using Microwave and followed by attachment of different hetrocycles to form Flavone derivatives and charactrarized by IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. These Flavone derivatives found to exhibit moderate to high inhibitory activity against Estrogen dependent cancers.
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