Dehradun

6 December 2012

CLINICAL INDICATIONS OF HEAT SHOCK PROTEINS (HSP): A PHARMACOLOGICAL REVIEW

About Authors:
Tarun Parashar^1*, Soniya¹, Satyanand Tyagi², Patel Chirag J³, Rishikesh Gupta⁴, Ram Narayan Prajapati⁴
¹*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248002.
²President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
*parashar89tarun@gmail.com, +91-7838447014/08006939831

ABSTRACT:
Heat shock proteins (HSP) are a group of proteins the expression of which is increased when the cells are exposed to elevated temperatures. HSP are present in cells under normal conditions, but are expressed at high levels when exposed to sudden temperature jump or other stress. HSP stabilize proteins and are involved in the folding of denatured proteins. High temperatures and other stresses, such as altered pH and oxygen deprivation, make it more difficult for proteins to form their proper structures and cause some already structures protein to unfold. Left uncorrected, mis-folded proteins form aggregates that may eventually kill the cell. HSB are induced rapidly at highly levels to deal with this problem. HSP have wide clinical applications, they are not only useful as Cancervaccine adjuvant as well as anticancer therapeutics, and also they are useful in agricultural field. The aim of present article is to provide in depth knowledge about clinical indications of these proteins so called as “Heat Shock Proteins”.
An attempt is also made to focus on functions, characteristics, types, qualities, clinical significance as well as brief description of Heatshock proteins.
4 December 2012

ROLE OF CASHEW NUTS AND OTHER NUTS IN THE MANAGEMENT OF DIABETES: A CLINICAL REVIEW

About Authors:
Satyanand Tyagi*, Patel Chirag J¹, Tarun Parashar², Soniya², Rishikesh Gupta³, Devesh Kaushik⁴
*President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy),
Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers, review articles and short communications. He is member of Editorial Advisory Board for some reputed Pharmacy Journals. He is appointed as an Author for International Pharmaceutical Writers Association (IPWA). (Appointed as an author for the chapters of book on Pharmaceutical Chemistry). His academic work includes 62 Publications (52 Review Articles, 08 Research Articles and 02 short Communications of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 62 publications, 11 are International Publications). His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders, psycho-pharmacological agents as well as epilepsy.
¹Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-302020.
³Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
⁴Territory Business Manager, Diabetes Division, Abbott Healthcare Private Limited, Okhla, New Delhi, India- 110020.
*sntyagi9 @yahoo.com, +91-9871111375/9582025220

ABSTRACT:
Diabetes is usually a lifelong (chronic) disease in which there are high levels of sugar in the blood. Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar), either because insulin production is inadequate, or because the body's cells do not respond properly to insulin, or both. Patients with high blood sugar will typically experience polyuria (frequent urination), they will become increasingly thirsty (polydipsia) and hungry (polyphagia). Cashew nuts have a relatively high fat content, but it's what dieticians consider “good fat.” It's good fat because it has the ideal fat ratio of 1:2:1 for saturated, monosaturated, and polyunsaturated fat.
17 September 2012

REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM

About Authors:
Bhuvnesh^*1, G.Gnanarajan¹, Preeti Kothiyal¹
Department of Pharmacy, Shri Guru Ram Rai Institute of Technology & Science P.O. Box
80, Patel Nagar , Dehradun 248001, Uttarakhand , India¹
*bhuvnesh.grg89@gmail.com

Abstract
Pulsatile drug delivery systems (PDDS) are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. A pulsatile drug release, where the drug is released rapidly after a well defined lag-time, could be advantageous for many drugs or therapies.A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time so as to match body’s circadian rhythms with the release of drug which increases the efficacy and safety of drugs by proportioning their peak plasma concentrations during the 24 hours in synchrony with biological rhythm. Pulsatile release systems can be classified in multiple-pulse and single-pulse systems. Various techniques are available for the pulsatile delivery like pH dependent systems, time dependent systems, etc. A popular class of single-pulse systems is that of rupturable dosage forms. Advantages of the pulsatile drug delivery system are reduced dose frequency; reduce side effects, drug targeting to specific site like colon and many more. Now in market varies technologies of pulsatile drug delivery system like Pulsincap, Diffucaps etc. are launched by pharmaceutical companies.

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11 July 2012

Work as Medical Representative in Sundyota Numandis Pharmaceuticals

Sundyota Numandis is a new-age pharmaceutical company, leveraging its experience, expertise and energies to better people’s lives.
Since its foundation in 2003, Sundyota Numandis has grown exponentially in a very short span. With over 600 employees & 21 distribution centers across the nation reaching over 80,000 retailers, they are amongst one of the fastest-growing pharmaceutical companies today with a proven track record of success year after year.
25 June 2012

A REVIEW ARTICLE ON: GENERAL CONSIDERATIONS FOR CLINICAL TRIALS (ICH EFFICACY TOPIC E8) AND MARKETING AUTHORIZATION

About Authors:
Vinay K. Gupta^*, G. Rajan and Preeti Kothiyal
Shree Guru Ram Rai Institute of Technology & Science,
Patel Nagar, Dehradun
*vngupta74@gmail.com

Abstract
The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is unique in bringing together the regulatory authorities and pharmaceutical industry of Europe, Japan and the US to discuss scientific and technical aspects of drug registration. Since its inception in 1990, ICH has evolved, through its ICH Global Cooperation Group, to respond to the increasingly global face of drug development, so that the benefits of international harmonization for better global health can be realized worldwide. ICH's mission is to achieve greater harmonization to ensure that safe, effective and high quality medicines. This contains four main topic that are Quality, Safety, Efficacy and Multidisplinary. Here we are mainly explain general aspects of clinical trial that are related to ICH E8 and procedure for marketing authorization of new drug substance in India
18 June 2012

Career in Sharon Bio - Medicine Ltd. as Senior Executive - QA (Formulations)

They aim at earning the reputation of being a reliable manufacturer and a force to reckon with in the area of Production of Chemical Intermediates, Bulk Actives and Pharmaceutical Formulations. They aim at being considered a benchmark when it comes to Production efficiency & excellence across the Globe. They see ourselves in the future as contributing to the success of our customers.
19 January 2012

Professor/Associate Professor and Asst. Professors required in Dev Bhoomi Group Of Institutions

DBIPR is situated in separate premises in Dev Bhoomi Campus Dehradun. The Institute offers AICTE & PCI Approved Four Year B.Pharmacy and 2 Year M.Pharmacy(Pharmacology) Courses Affiliated to Uttrakhand Technical University, Dehradun.

Post: Professor/Associate Professor and Asst. Professors
6 January 2012

Wanted Assistant Manager QA in Hema laboratories

Originally Gujarat based Company presence of 35 years in Pharma formulation having own marketing setup as well as 3rd party/loan licence activity at Gujarat and Dehradun plant.

Post: Assistant Manager- Q.A.
3 January 2012

QC JOB: QC officer invited in Hema Laboratories - 02 posts

Originally Gujarat based Company presence of 35 years in Pharma formulation having own marketing setup as well as 3rd party/loan licence activity at Gujarat and Dehradun plant.

Post: QC officer
3 January 2012

Opening as QA officer in Hema Laboratories - 4 openings

Originally Gujarat based Company presence of 35 years in Pharma formulation having own marketing setup as well as 3rd party/loan licence activity at Gujarat and Dehradun plant.

Post: Officer – QA