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  • PharmaTutor
    11 September 2012

    GLYCOGEN SYNTHASE KINASE: A DRUG TARGET IN TREATMENT OF CNS DISORDER

    About Authors:
    Najneen S. Shaikh1*, Mr. MAYURESH. K. RAUT2
    1Sinhgad Institute of Pharmaceutical Sciences (SIPS), Lonavala
    2Asst. Professor Of Phamaceutical Chemistry
    Sinhgad Technical Education Society,
    Kusgaon (Bk), Lonavala- 410401
    *naj.pharma.23@gmail.com

    ABTRACT
    Glycogen synthase   kinase 3 (GSK-3) is a serine/threonine protein kinase, that mediates the addition of phosphate molecules on certain serine and threonine amino acids in particular cellular substrates.
    Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with these diseases. GSK3 is a widely influential enzyme that is capable of phosphorylating, and thereby regulating, over forty known substrates. Four mechanisms regulating GSK3 (phosphorylation, protein complexes, localization, and substrate phosphorylation) combine to provide substrate-specific regulation of the actions of GSK3. Several intracellular signaling cascades converge on GSK3 to modulate its activity, and several neurotransmitter systems also regulate GSK3, including serotonergic, dopaminergic, cholinergic, and glutamatergic systems. Because of changes in these neurotransmitter systems and the actions of therapeutic drugs, GSK3 has been linked to the mood disorders, bipolar disorder and depression, and to schizophrenia.

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  • 10 September 2012
    Opening for Assistant Professor in RASA Lifesciences

    RASA Life Science Informatics, a Bio-Chemoinformatics company based in Pune, provides unmatchable training facilities to students and professionals in Life Science Informatics. We are now launching a 100% Job oriented Training program, Academic & Industrial Projects to enable anyone and everyone to get trained and get placed.

  • 4 September 2012
    Opening for Area/Regional Managers, Country manager in Leading pharma company located in Mumbai

    Leading pharma company located in Mumbai; Manufacturing of Sustained & modified release, Pellets, DC granules, Taste mask Granules, Tablets & Capsules.

  • 3 September 2012
    Job as Pharmacist in Mazagon Dock- Government of India

    Mazagon Dock Limited is the India’s premier shipyard constructing warships as well as offshore platforms.

  • 2 September 2012
    Saraswathi Vidya Bhavan’s College of Pharmacy invites Professor, Associate Professor, Assistant Professor- 8 Posts

    Saraswathi Vidya Bhavan’s College of Pharmacy is affiliated to the University of Mumbai and Approved by All India Council for Technical Education (AICTE). The College offering Bachelor of Pharmacy and Bachelor of Pharmacy course.

    APPLICATIONS ARE INVITED FOR THE FOLLOWING FULL TIME POSTS FOR ACADEMIC YEAR 2012-13.

  • 30 August 2012
    Opening for Jr. Application Scientist and HR Trainee in RASA Lifesciences - freshers

    RASA is a Bio & Chemo Informatics company offering solutions and services in the area of Life sciences. We are looking for young talented students who are willing to grow with us. We entertain only freshers because we feel that it is easier to train them in the specific fields rather than training experienced professionals.

  • 29 August 2012
    walk in interview for Junior Research Fellow, Research Associate in ACTREC

    The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia.

  • 27 August 2012
    Require DRA Executive in Marion Biotech - 2 posts

    Marion Biotech strongly believes in an integrated approach to healthcare. It is also engaged in extensive Research & Development of unique Herbal products. At Marion Biotech, we set Stringent Standards of Quality, Safety and Efficacy for all the Products that we manufacture.

  • 27 August 2012
    Job as Senior/Executive - Marketing (3 Posts) in Leading pharma company located in Mumbai

    Leading pharma company located in Mumbai; Manufacturing of Sustained & modified release, Pellets, DC granules, Taste mask Granules, Tablets & Capsules.

  • 26 August 2012
    ENHANCEMENT OF DISSOLUTION RATE OF OLANZAPINE USING SURFACE SOLID DISPERSION TECHNIQUE

    About Authors:
    Borse V. G.*, Birajdar A. S., Datal A. A.
    K. T. Patil College of Pharmacy,
    Osmanabad-413501, Maharashtra, India.
    *vishalgborse@gmail.com

    ABSTRACT :
    The objective of this study is to enhance dissolution rate of practically insoluble drug olanzapine, using surface solid dispersion technique. Olanzapine is classified as a thiobenzodiazepine atypical antipsychotic drug used in the treatment of schizophrenia. Surface solid dispersion technique is used to prepare solid dispersion of olanzapine using Crospovidone as carrier. Surface solid dispersion were characterised by saturation solubility studies, drug content and in- vitro dissolution studies. Solubility studies revealed a marked increase in the solubility of olanzapine with an increase in Crospovidone concentration. The best dispersion was selected based on saturation study and release study and evaluated for solid state characterization techniques Differential scanning calorimetry, FT-IR spectroscopy study. The results from DSC and IR indicated that there was no interaction between drug and carriers. Surface solid dispersion of olanzapine shows increase in aqueous solubility 4.42 fold than pure drug. SSD with Crospovidone in 1:9 ratio give highest drug release i.e. 88.87%.Surface solid dispersion is successful technique to improved drug dissolution of olanzapine with the carrier Crospovidone.

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