Maharashtra

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an 'Institute of National Importance'. It is an autonomous body set up under the aegis of Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India.

SAC ACCP was established in 2006. It all started with the ACCP board of regents under the leadership of Dr. Lawrence Lesko (ex president of ACCP), proposing at the meeting in March 2005, to explore setting up international chapters. Dr. Chandrahas Sahajwalla, then chair of the Membership committee for ACCP took the lead in identifying qualified scientists in India with passion and drive to promote Clinical Pharmacology and the principles and values of ACCP. On March 14, 2005 Dr. Sahajwalla invited Dr.

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ABOUT AUTHORS:
Rajmahamad H. Shaikh¹*, Mohsin J. Jamadar¹, Amol D. Patil¹, Audumbar D. Mali², Sanauaha M.Tamboli^1
1Department of Pharmaceutics, Appasaheb Birnale college of Pharmacy, Sangali, Maharashtra, India.
²Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India
rajshaikh71@gmail.com

ABSTRACT:
The purpose of this investigation was to enhancement of solubility of cinnarizine by using solid dispersion technique solvent evaporation method using polymer PEG 6000 & develop combination ODT of cinnarizine with domperidone by using direct compression technique using crospovidone, croscarmellose sodium and sodium starch glycolateas a superdisintegrants. The preformulation study includes the compatability of drugs with the polymers by using FTIR,UV,TLC. The batches were evaluated for weight variation, hardness, friability, drug content, wetting time, IN In-vitro dispersion, in-vitro dissolution. The formulation F2 which contain 8% crospovidone and 10 % sodium starch glycolate showed best results and rapid in-vitro dissolution. The results revealed that the tablets containing superdisintegrants combination had a good dissolution profile. The drug content of all the batches was within the acceptable limits of the United States Pharmacopoeia with maximum drug being released at all timeintervals. The present study demonstrated potentials for rapidabsorption, improved bioavailability, effective therapy and patientcompliance. The results conclusively demonstrate successful enhancement of solubility, disintegration and dissolution of the formulated tablets.

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Mazagon Dock Limited invites applications from eligible candidates in the category of SC, ST, OBC (Non creamy Layer), PWD(HH & OH) and UR(General) for the posts of Technical Staff and Operatives in various trades in Skilled & Semi-skilled grades for appointment on Contract Basis for a maximum period of two years. The details are as follows:-

Post: Pharmacist

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ABOUT AUTHORS:
Shete Reshma S.¹*, Gadhave Manoj V.², Gaikwad D. D.^3
1Department of Quality Assurance Techniques,
²Department of Pharmaceutics,
³Department of Pharmaceutics,
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
*reshma.s.shete@gmail.com

ABSTRCT
Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin, PEG 6000 & Poloxamer 407 solid dispersions were prepared with a view to study the influence of polymer on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of PEG 6000 & Poloxamer 407 as carrier by, solvent evaporation method. They were evaluated for percentage yield, drug content, FTIR spectral studies, DSC, XRD, solubility, and in-vitro dissolution. The solubility profile indicated that there is increase in solubility of Simvastatin when polymer concentration is increased. The solid dispersion complex of drug (1:5:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions. This in turn can improve the bioavailability. FT-IR, DSC shows the compatibility of drug and carrier.

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Post: Pharmacist