R&D

About Authors:
RAVISANKAR.M*¹, SUBASINI.U², ANAND THANGADHURAI.S³, KARTHIKEYAN.S⁴, CHANDRA SEKAR.E.^5
1.Swamy Vivekanandha College of pharmacy, dept of pharmaceutical analysis. Thiruchengode
^2.Swamy Vivekanandha College of pharmacy, dept of pharmacognosy. Thiruchengode
^3.Swamy Vivekanandha College of pharmacy, dept of pharmaceutical analysis. Thiruchengode
^4.Kausikh therapeutics and private limited.chennai
^5.Swamy Vivekanandha College of pharmacy, dept of pharmaceutical analysis. Thiruchengode

ABSTRACT
An isocratic reverse phase high performance liquid chromatographic method for estimation of montelukast sodium and levocetirizine in bulk dosage and in marketed formulations has been devised and validated. The chromatographic separation achieved on shodex c18-4E column (5µm, 250 mm x 4.6 mm) and  acetonitrile: methanol: ammonium acetate buffer (PH- 5.5) in the ratio of 25:55:20 v/v. The flow rate was 1.0 ml/min and the UV detection was identified at 225nm.The retention times for montelukast sodium and levocetirizine was found to be 5.15 min and 3.12 min respectively. The linearity of montelukast sodium and levocetirizine is 10 -50µg/ml with the correlation co efficient 0.99 respectively. The validation parameters such as accuracy, precision, LOD, LOQ, Robustness, ruggedness were performed as per ICH guidelines. This method can be used for routine analysis of montelukast sodium and levocetirizine in bulk and marketed dosage forms.

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About Authors:
Manoj Kumar Jadia^1*, U.L.Narayan^2
1 Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceautical Sciences, I.R.C. Village, Bhubaneswar, Dist:Khurda, Odhisa -751015
² Principal, Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceautical Sciences, I.R.C. Village,
Bhubaneswar,
Dist:Khurda, Odhisa -751015

Abstract:
Two methods are described for the simultaneous determination of Paracetamol and Chlorzoxazone in binary mixture. The first method was based on UV-spectrophotometric determination of two drugs, using simultaneous equation method. It involves absorbance measurement at 282.5 nm (λmax of Chlorzoxazone) and 248.0 nm (λmax of Paracetamol) in methanol; linearity was obtained in the range of 5 – 25 μg.mL-1 for both the drugs. The second method was based on HPLC separation of the two drugs in reverse phase mode using Promosil C18 column. Linearity was obtained in the concentration range of 100-500 μg.mL-1 for Paracetamol and 50-250 for  the Chlorzoxazone. Both these methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.

The Indian Registry of Pathology (IRP) was established in 1965 under the auspices of the Indian Council of Medical Research (ICMR) in New Delhi, India as a Centre for collection and distribution of teaching material in pathology. The Registry was renamed in 1980 as the National Institute of Pathology (IOP) in view of its expanded scope and activities.

Taurus Biotech is representing a consultancy firm Headquartered in Toronto, Canada, which serves the pharmaceutical, medical devices and biotechnology industries in North America and internationally since 1997, in the field of drug discovery, strategic planning to process scale up having esteemed clientele like Pfizer, Cibavision,Sanofi Pasteur,Wyeth,Biovail,Apotex,Schering-Plough and Canadian Blood services etc.

CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), a multidisciplinary multilocational research laboratory of Council of Scientific and Industrial Research (CSIR) invites applications from enthusiastic, young and dynamic Indian Nationals having excellent academic record/proven scientific achievements and the ability to undertake R&D in an innovative way for the following posts of Scientists/ Sr. Scientists in the areas as given below:

ABOUT AUTHORS:
RANI SHALU^1*, SAROHA KAMAL¹, NANDA SANJU^2
1Institute of Pharmaceutical Sciences,
Kurukshetra University, Kurukshetra 136119, Haryana, India.
²Department of Pharmaceutical Sciences,
MDU, Rohtak 124001,
Haryana, India.

ABSTRACT
The aim of the present study was to investigate the in-vitro release properties of Ziprasidone hydrochloride monohydrate from different topical vehicles. By the unique advantages over the traditional drug delivery, transdermal drug delivery is becoming increasingly important and has got a vital interest in pharmaceutical industries. An in vitro release experiment was designed to reveal the rate of release of ziprasidone hydrochloride monohydrate from four different topical vehicles: (i) cream; (ii) a gel; (iii) an ointment (iv) pronoisomal gel. In vitro release of ziprasidone hydrochloride monohydrate from the four bases was monitored spectrophotometrically at a wavelength of 318 nm. In vitro release study results showed that the release of drug from vehicles ranks according to the following order: gel> proniosomal gel> cream> ointment. Gel base showed considerably higher drug release than other vehicles. Five types of chemical enhancers was used in the study and among them tulsi oil was the best enhancer. As we increase the concentration of chemical enhancer the release of drug also increases. By monitoring and attempting to explain the many possible reasons for the different rates of drug release from the vehicles, it was hope that the experiment would confer essential information concerning factors affecting the release of drugs from topical formulations.