Nesar Ahmad*,Zafar Khan, Noorul Hasan, Abdul Basit, Seikh Zohrameena
Department of Pharmacology,
Faculty of Pharmacy,
Integral University, Lucknow, UP, India

Stroke is a destructive experience which can result in permanent disability in brain. There is no permanent drug which can improve the blood flow at infracted area and also improve the neurological deficit. Due to the lack of treatments available for stroke, many researchers will investigate the suitable plants or drugs for the treatment of this disease. Numerous medicinal plants and herbal drugs are available to treat stroke, some of the plants are Ginkgo biloba, Fructus Chebulae, Pomegranate, Rosa laevigata, Garlic, Leonurus heterophyllus, Olive, Grape, Allium cepa, drugs such as Pravastatin, Senkyunolide I, Phloretin, Mgso4, HAMI 3379, Oleoylethanolamie, scopolamine and mecamylamine, Nitric Oxide, N-nitro-L-arginine methyl ester (L-NAME), 3,5,6,7,8,3’,4’-Heptamethoxy flavones, Rosiglitazone, Puerarin, the activity was estimated by parameters like superoxide dismutase (SOD) activity, Hemispheric swelling index (cerebral edema), H2O2 induced cell injury, OGD-R induced cell injury, superoxide dismutase and glutathione peroxidises, mitochondrial membrane potential, Western blotting assay, ROS scavenging assays, Superoxide anion  scavenging assay, Hydroxyl radical  scavenging assay, H2O2 scavenging assay, Singlet oxygen scavenging assay, Peroxyl radical scavenging assay, Peroxynitrite anion scavenging assay, myeloperoxidase (MPO) activity, blood–brain barrier integrity, cerebral infarct size, in Situ Apoptosis Detection, Western blotting, SOD, GSH, glutathione peroxidase, and MDA levels, Reverse transcription polymerase chain reaction (RT-PCR), Lactate dehydrogenase activity assay, Determination of caspase activity, acetylcholinesterase (AChE) activity, Determination of choline acetyltransferase activity (ChAT), Cell viability, Oxygen glucose deprivation/reperfusion assay, Flow cytometry, Immunohistochemistry.  The present review focused on different medicinal plants and drugs that have been tested in Stroke in animal models.

National Eligibility Test - 2017 for Pharmacy graduates

CSIR will hold the Joint CSIR-UGC Test Tentatively on Sunday 18th June, 2017 for determining the eligibility of the Indian National candidates for the award of Junior Research Fellowships (JRF) NET and for determining eligibility for appointment of Lecturers (NET) in certain subject areas falling under the faculty of Science & Technology. The award of Junior Research Fellowship (NET) to the successful eligible candidates will depend on their finding admission/placement in a university/ national laboratory/ institution of higher learning and research, as applicable.

Multiple Job openings in CavinKare

CavinKare- a youthful company fired by ideas, dynamism and professionalism first entered the hair care arena in 1990. The success story began with Chik shampoo, the name which rewrote every rule in the market by popularizing the sachet concept in India.
In this short span of time, CavinKare has not merely taken on the mighty MNC challenge but notched up a stupendous 46% compounded annual growth along the way.

Opportunity to work as Zonal Sales Manager at Johnson & Johnson

Johnson & Johnson operates as a single legal entity and consists of the 3 strategic business units: Consumer Products, Pharmaceuticals and Medical Devices & Diagnostics, which are independently managed and report into their respective Global business segments.  J&J Medical India (JJMI) is the market leader in the Medical Company Devices & Diagnostics Industry in India. It is in the business of caring and providing solutions to doctors, patients and nurses. It comprises of multiple Franchises (Strategic business units) providing healthcare solutions across Vision Care, Orthopaedics, Infection Prevention, Wound Management, Women’s health, minimally invasive surgery, Circulatory disease management, and Blood glucose monitoring and insulin delivery.

Post : Zonal Sales Manager

Walk in at National Botanical Research Institute for various postions

CSIR- National Botanical Research Institute (NBRI), Lucknow, a constituent laboratory of Council of Scientific & Industrial Research (CSIR), is a premier plant science research institute, involved in multidisciplinary R&D programmes of both basic and applied nature across scientific disciplines for economic, environmental and societal benefits for the people of India. CSIR-NBRI undertakes basic and applied research in strategically important areas of plant sciences.

Eligible & interested candidates are invited for interview for the purely temporary positions in the following areas under the sponsored projects tenable at CSIR-NBRI:-

Post: Research Associate, Senior Project Fellow, Project Fellow/Project Assistant Level II/III

Career as Consultants in Central Drug Research Institute - Ph.D in life sciences / animal sciences

CDRI is the seventh among the laboratories established by Government of India as a constituent laboratory of Council of Scientific and Industrial Research, New Delhi. The idea for establishment of a laboratory exclusively for drug research was put forward by Dr. B. Mukerji, the then Director, Biochemical Standardization Laboratory, Calcutta in his presidential address to the Physiology session of the Indian Science Congress held at Nagpur in 1945.

Walk in interview for Marketing Executives / Medical Rep. at Alkem Laboratories

Alkem Laboratories Ltd. was founded in the year 1974 with a dream to reach out quality Health food to people and improve quality of life with exceptional products and services. Nearing its fourth decade of successful existence, Alkem Lab’s dreams have transpired to elevate the lives of millions of people worldwide. Propelled with dedication and the passion to achieve and deliver, Alkem Lab’s has journeyed to be known the world over as a premier Health food institution in generic and branded formulations.  we are looking for Energetic, Enthusiastic & Motivated personnel for our formulation unit-Sikkim.

Post : Marketing Executives / Medical Rep.



Noorul Hasan*, Mohd. Mujahid, Badruddeen, Nesar Ahmad, Shahla Parveen, Shaikh Zohrameena, Zafar Khan
Faculty of Pharmacy,
Integral University, Lucknow, U.P. (India)

Attention-deficit/hyperactivity disorder (ADHD) is a neurobehavioral condition primarily affecting children but regularly persisting into adolescence and adulthood. The symptoms must present in multiple settings ie home, school, work, be inappropriate for developmental level and interfere with the individual’s level of functioning, social development, learning processes, and quality of life. There are three presentations of ADHD i.e. inattentive, hyperactive and combined. There is a substantial pharmacopoeia available for safe and effective treatment of ADHD. CNS stimulants like methylphenidate, amphetamine are recommended as first-line medication therapy for children. It includes various class of drugs like centrally acting sympathomimetic, anti-psychotic, anti-depressant (SSRI), alph2 agonist and some newer agent like atomoxetine in the treatment of ADHD. ADHD remains the only highly prevalent, nondegenerative neuropsychiatric disorder for which effective medications remediate the principal cognitive disturbances in concert with clinical efficacy. Therefore, deeper insight into the neural mechanisms of cognitive remediation may serve to advance treatment development not only in ADHD, but across a wide range of neuropsychiatric disorders in which cognitive dysfunction is a cardinal feature and a strong predictor of clinical outcome. All effective medications for ADHD act on one or both of the major catecholamine neurotransmitter systems in the brain. These 2 systems, which arise from subcortical nuclei and use of norepinephrine (NE) or dopamine (DA) as transmitters exert strong modulatory effects on widely distributed cortical–subcortical neural circuits, with important effects on cognition, mood and behavior in both health and illness