Tamil Nadu

A STUDY ON COGNITIVE DYSFUNCTION IN EARLY STAGE OF DIABETES

About Author:
Hiren Sakhiya,
M.Sc in Clinical Research Management,
Prist University, Thanjavur,

India
*sakhiyahiren@gmail.com

ABSTRACT
Diabetes a chronic (lifelong) disease marked by high levels of sugar in the blood. Diabetes is a common disease in older age, affecting about one in five individuals. In 2000, according to the World Health Organization, at least 171 million people worldwide suffer from diabetes, or 2.8% of the population. Its incidence is increasing rapidly, and it is estimated that by 2030, this number will almost double. Diabetes is also associated with mortality and significant morbidity, including neurological disability. Diabetes affects both peripheral nervous system and central nervous system. Neuropathy along with retinopathy and nephropathy appears in late stage of diabetes but effect on cognition starts in early stage of diabetes. Although the effects of diabetes on the peripheral nervous system are well established, the effects of diabetes on the central nervous system have been less clear. Several studies have found that diabetes is related to dementia and cognitive function. It is unclear in which stage of diabetes the cognitive decrements become manifest and how they progress over time. Study is conducted to confirm the association of cognitive function with diabetes.

FORMULATION AND IN-VITRO CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF CHITOSAN LOADED WITH RAMIPRIL

About Authors:
Yamini Pendyala*, Sudha Talasila, M.sulthana
Department of Pharmaceutics,
Padmavathi College of Pharmacy and Research Institute,
Periyanahalli, Tamilnadu.

*Yamini.pendyala45@gmail.com

ABSTRACT
The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive Ramipril microspheres for its potential use in the treatment of hypertension, myocardial infraction. Ramipril mucoadhesive microspheres, containing chitosan as mucoadhesive polymer and ethyl cellulose as carrier polymer, were prepared by an emulsion-solvent evaporation technique. Preformulation studies were carried out before formulation design. Total seven formulations were prepared.Microspheres were discrete, spherical, free-flowing and showed a good percentage of drug entrapment efficiency. An in-vitro wash off test showed that Ramipril mucoadhesive microspheres adhered more strongly to the gastric mucous layer and could be retained in the gastrointestinal tract for an extended period of time. In-vitro dissolution test was carried out by using phosphate buffer pH 6.8. All the formulations showed good dissolution profiles. Among all the formulation F5 showed good dissolution profile with 81.0% of drug release in 12 hours. In-vitro release kinetic data of Ramipril microspheres showed that the drug release mechanism was diffusion controlled as the plots of Higuichi model was linear. All formulations exhibited Non-Fickian diffusion (n value is in between 0.5 to 1) mechanism. Stability studies were done for the selected formulation indicates that there is no change in drug content of the formulation.The results showed a sustained anti-hypertensive effect over a longer period of time in case of mucoadhesive microspheres, compared to the powder. In conclusion, the prolonged gastrointestinal residence time and slow release of Ramipril resulting from the mucoadhesive microspheres, could contribute to the provision of a sustained anti-hypertensive effect.

Indian Immunologicals invites Production Executive- Blending, Formulation

The National Dairy Development Board (NDDB) set up Indian Immunologicals Ltd. (IIL) in 1982 with the objective of making Foot and Mouth Disease (FMD) vaccine available to farmers at an affordable price. The technology for FMD vaccine manufacture was obtained from M/s. Wellcome Foundation Limited, United Kingdom. The plant in Hyderabad today has a capacity to make 80 million trivalent doses of FMD vaccine.

Job for Freshers as Production Chemist in Axon Drugs - 3 Posts

Axon Drugs is a thriving pharmaceutical company headquartered at Chennai, the southern Metropolitan city which has fast developed into a primary business destination in India. Axon started off with supply of medicines to Government Institutions in the form of tenders. Gradually, with this expertise Axon ventured into higher avenues.

Application are invited for the post of Assistant Manager Medical Coding

“ELICO” The name which pioneered and gave new meaning and direction to the word Analytical Instrumentation in India and electronics in state of Andhra Pradesh, and this word “Electronics” has now become the identity of Hyderabad. The company commenced its operations in 1959 slightly more than a decade after Independence of Country. It was a time when there were very few players nationally in the technology arena and none locally.

Opening for Head - Application Development Center in Manali Petrochemicals

Manali Petrochemicals Limited (MPL) is an India leader in the production and marketing of propylene oxide, propylene glycols and polyols that find widespread application in the pharmaceutical, food, fragrance, automobile, garments, refrigeration and the oil & gas industries. MPL's turnover for FY 2011 was INR 4530 million.

PREVENTION OF NOSOCOMIAL INFECTIONS

About Authors:
*1P.SanilKumar, 1C K. Dhanapal, 2Sandhya Ravi
1Department of Pharmacy,
Annamali University, AnnamaliNager,
Chidambaram, Tamilnadu.
2Lotus Labs Pvt Ltd,
No.07, Jasmabhavan Road, Vasanthanager, Bangalore, Karnataka.

*sanilmpharm@gmail.com

ABSTRACT
Hospitals are created for cure the disease but not for the spreading of diseases, even though this statement is true to the theoretical concept but it is not possible practically due to various risk factors. The spread of infection in the hospitals occurs due to the microorganism. Nosocomial infections add significantly to the economic burden of managing the underlying disease that has lead to hospitalization of the patient. More than 90% of reported infections are bacterial where as viral, fungal or protozoal infections are less commonly involved in hospital-acquired infections. This project deals with bacterial nosocomial pathogens only, since they are by far major causes of nosocomial infections. Objective of the present study include  the identification, prevention and control of nosocomial infection in our hospitals. The ultimate aim is the reduction of nosocomial infections and their costs. Baseline study for morbidity pattern in the hospitals, finding sources of exogenous and endogenous sources of nosocomial infection. Suggest measures to minimize the nosocomial infections and suggest guidelines for efficacious management of nosocomial infections.

Work as Research Associate - Quality Assurance in Micro Therapeutic Research - 2 posts

Micro therapeutic Research Labs (MTR) is a quality driven, full service oriented Clinical Research Organization (CRO) that provides a broad range of clinical research services to the global pharmaceutical and biotechnology industry.
Situated in three different locations namely Selaiyur, Coimbatore and Padi in Tamilnadu, the southern part of India; Micro Therapeutic Research Labs offers you world-class services that are truly customized for your unique research requirements.

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