Tamil Nadu

Effect of Convolvulus Pluricaulis in Obsessive Compulsive Disorder using Animal models

About Authors:
Revathy subramani, Anand M., Muralidharan P.
Department of pharmacology,
C.L. Baid metha college of pharmacy,
Thoraipakkam, Chennai 600097
,
India

Abstract
Obsessive Compulsive Disorders (OCDs) involve habitual, repetitive behaviors that can be bizarre, disruptive and eventually disabling and it is characterized by intrusive thoughts. Aim of this study is to investigate the methanolic extracts of convolvulus pluricaulis (MECP) action on OCD with animal models by using invivo pharmacological evaluations such as Marble burying behavior, Hole board test, Rota-rod test using mice. These tests are well-accepted paradigm to screen anti-compulsive activity and it also reflects an anxiety-like responses. In this study we used seven groups of mice all the three tests were made on the seven groups. First group serves as control. Second and third groups were treated with 15 mg/Kg and 30 mg/Kg of fluoxetine which is a standard drug and also it is a selective serotonin reuptake inhibitor (SSRIs). Then fourth and fifth groups were treated with 2.5 mg/Kg and 5 mg/Kg of diazepam which is an anxiolytic-sedative drug useful in the symptomatic relief of anxiety and tension states it serves as a negative control. Sixth and seventh groups were treated with 200 mg/Kg and 400 mg/Kg MECP the results show that the MECP can modulate serotonin or dopaminergic levels, which is the major pathway of OCD pathophysiology. Involvement of the serotonergic or dopaminergic receptors for its effect on OCD has been planned based on this study.

Opening in NATIONAL INSTITUTE FOR RESEARCH IN TUBERCULOSIS to Study the baseline anti TB and anti HIV properties of novel antibiotic Transitmycin

The Tuberculosis Research Centre (TRC), a permanent institute under the Indian Council of Medical Research (ICMR), is an internationally recognized institution for Tuberculosis (TB) research. It is a Supranational Reference Laboratory and a WHO Collaborating Centre for TB Research and Training. Recently, an International Centre for Excellence in Research (ICER) in collaboration with NIH was established at the Centre.

Pharmacognostical and Pharmacological studies of Holoptelea integrifolia – An overview

About Authors:
Soujanya J, Silambujanaki P, Leela Krishna V
Department of Pharmacology, SRM College of Pharmacy,
SRM University, Kattankulathur-603203,
Kancheepuram Dist.,
Tamil Nadu, India

Abstract
Holoptelea integrifolia, Planch. is a widely used herb in traditional medical systems of India.It is an important pollen allergen of India andsensitizes almost 10% of the atopic population in Delhi.Various parts of Holoptelea integrifolia, a roadside plant, are indicated by Charaka Samhitha, Sushrutha Samhitha and other traditional systems for the treatment of inflammations, acid gastritis, dyspepsia, flatulence, colic, intestinal worms, vomiting, wounds, vitiligo, leprosy, filariasis, diabetes, haemorrhoids, dysmenorrhoea and rheumatism.The present review is therefore, an effort to give a detailed survey of the literature on its pharmacological, traditional and phytochemical properties

Development of HPTLC Finger Printing of Different Variety of Piper Betle Linn Leaf Oil Grown in Tamilnadu

About Author:
Sugumaran M., T. Vetrichelvan
Department of Pharmaceutical Chemistry,
Adhiparasakthi College of Pharmacy,
Melmaruvathur - 603 319, Tamilnadu , India

Abstract
High performance thin layer chromatographic finger print parameters had been developed for  Piper betle leaf oilisolated from karpoori, sirugamani and vellaikodi variety available in tamilnadu to fix standards. At shorter wavelength (254 nm) resolution was better for, so, this wavelength can be taken for obtaining optimum HPTLC finger printing for  volatile oil of this medicinal plant leaves. As per the data,   Karpoori variety of piper betle leaf oil  only showed  presence of  eugenol content. So, essential oil obtained from this variety should be included in the commercial tooth paste to get  antimicrobial activity against dental pathogens when compared to other studied variety.

Antioxidant Activity of Flowers and Leaves of Tabernaemontana Divaricata Linn.

About Author: C. Stalin*, S. Kamalasivam, E. Hariharan,
Pallavan College of Pharmacy,
Kancheepuram, Tamilnadu.

Abstract:
Tabernaemontana divaricata a common garden plant in tropical countries has been used as a traditional medicine. However, no recent review articles of T. divaricata, particularly discussing its pharmacological properties, are available. In present study, the antioxidant activity of ethanolic extract of flowers and leaves of Tabernaemontana divaricata linn were evaluated . Free radicals have been regarded as a fundamental cause of different kinds of diseases. They cause biochemical damage in cells and tissues, which result in several diseases such as arteriosclerosis, ischemia-reperfusion injury, liver disease, diabetes mellitus, inflammation, renal failure, aging, cancer, etc. Compounds that can scavenge free radicals are thus effective in ameliorating the progress of these related diseases. T.divaricata L. known locally as ‘Nandiyavattom’ belonging to the family, Apocynaceae a common plant in India, profoundly used in Ayurvedic medicine as  Anthelmintic, Anti-inflammatory, Anodyne, Diuretic property.1 The objective of the present study was designed to investigate the antioxidant efficacy of ethanolic extract of leaves and flower of Tabernaemontana divaricata (TALE & TLFE). Invitro antioxidant activity such as Reducing power ability ,  NBT reduction assay, Deoxyribose degradation assay was performed and was concluded that the ethanolic extract of leaves and flowers of Tabernaemontana divaricata showed significant antioxidant activity.

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