Kolhapur

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS FROM SOLID DISPERSIONS OF LOVASTATIN

About Authors:
Khayyam Shaikh*, Patwekar Shailesh, Santosh Payghan, John Disouza
Department of Pharmaceutics,
Tatyasaheb Kore College of Pharmacy,
Warananagar, Kolhapur, Maharashtra, India 416113.
*ramzanshek0587@gmail.com

ABSTRACT
During the last two decades there has been a remarkable increase in interest in sustained release drug delivery system. This has been due to various factors viz. the extensive cost of developing new drug entities, expiration of existing international patents, discovery of new polymeric materials suitable for prolonging the drug release, and improvement in therapeutic efficacy and safety achieved by this delivery system. A number of design options are available for the preparation of controlled release formulations to modify oral absorption. Formulation approaches are being explored to enhance bioavailability of poorly water-soluble drugs. One such approach that has been shown significantly enhanced absorption of such drugs is to formulate solid dispersionand then formulate its tablets. Solid dispersion technology can be used to improve the in- vitro and in- vivo dissolution properties of slightly water soluble drugs and to control their dissolution rate. In this current study attempts have been made to formulate sustained release tablets of solid dispersions.

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Pharmacological Screening of Ethanolic Extract of Plant Solanum XanthocarpumOn Nephrolithiasis Rats

About Authors:
Amar Patil*, Shraddha Kanase
M.Pharm (Pharmacology)    
Department Of Pharmacology, Tatyasaheb Kore College Of Pharmacy,
Warananagar. Dist;Kolhapur, India .
*appatil.tkcp@gmail.com

Abstract:
Solanum Xanthocarpumhas been known traditionally in Indian system of medicine for the treatment of various metabolic disease and disorders. Since, the present study was carried out to know its applicability in urolithiasis condition. In the present study, extracts of Solanum Xanthocarpumwas prepared with Ethanol and used for evaluation of antiurolithiatic activity. In this study we systematically evaluated its property by using Ethylene Glycol induced Albinorats. This study also involves state of the art animal model to elucidate its probable mechanism of industrial guidelines of FDA, USA for pre-clinical evaluation of anti-Nephrolithiasis drugs.

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Post: BUSINESS DEVELOPMENT EXECUTIVE

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