Use of antidepressants and painkillers combinely can lead to increased risk of bleeding soon after starting treatment, claims a new study by a team of researchers based in Korea.
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Researchers suggested that special attention was needed when patients use both these classes of drugs together. They found combined use of antidepressants and NSAIDs was associated with a substantially increased bleeding risk.
NSAID prescriptions were obtained and hospital records were used to identify time to first admission with intracranial hemorrhage within 30 days of a new prescription. Factors that could affect the results, such as age, sex, and use of other medications, were taken into account. Being male was the most common factor for a higher risk of bleeding with combined use of antidepressants and NSAIDs.
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The addition of NSAIDs to antidepressant treatment increased the risk of intracranial hemorrhage within 30 days of the combination starting, especially in men.
The study is published in The BMJ.
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