• PharmaTutor
    28 June 2012

    DEVELOPMENT OF GASTRORETENTIVE FORMULATION OF ALPRAZOLAM

    About Authors:
    Pavitra Solanki1, Satyaveer Singh Solanki2
    1- Research Scholar, KIET school of Pharmacy, Ghaziabad.
    2- Asstt. Professor, Nehru Mahavidhyalaya, Lalitpur, Uttar Pradesh
    *pavitra.bpharma@gmail.com

    Abstract
    The goal in designing controlled floating delivery system to reduce the frequency of dosing and / or to increase effectiveness of drug by localization at the site of action, reducing the dose required or providing uniform drug delivery with high bioavailability of buoyant drugs and also reduce the severity and frequency of side effects by maintaining patient blood levels of the drug above the minimum effective level and below the minimum toxic level.
    Oral route has been the commonly adopted and most convenient route for drug administration. Oral route of administration has been received more attention in the pharmaceutical field because of the more flexibility in the designing of dosage form than drug delivery, design for other routes.  For sustained drug delivery dosing interval can be extended either by manipulating the drug molecule to reduce the rate of elimination or by altering the release rate of a dosage form to retard the rate of absorption. Both these approaches decrease fluctuating in plasma level in case of multiple dosing extending the dosing interval without under or over dosing.

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