Jaipur

19 September 2012

DIFFERENT METHODS OF ENHANCEMENT OF SOLUBILIZATION AND BIOAVAILABILITY OF POORLY SOLUBLE DRUGS: A RECENT REVIEW

About Authors:
Patel Chirag J*, Asija Rajesh, Asija Sangeeta
Maharishi Arvind Institute of Pharmacy, Department of Pharmaceutics,
Jaipur, Rajasthan.
*chirag.bangalore@gmail.com

ABSTRACT
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. The insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds. This review discusses BCS classification, carriers for solubility enhancement and different techniques for solubility enhancement.Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include micronization, nanonization, sonocrystallization, supercritical fluid method, spray freezing into liquid and lyophilization, evaporative precipitation into aqueous solution, use of surfactant, use of co-solvent, hydrotropy method, use of salt forms, solvent deposition, solubilizing agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in carriers.Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.With the advent of combinatorial chemistry and a high throughput screening, the number of poorly water soluble compounds has increased solubility. A success of formulation depends on how efficiently it makes the drug available at the site of action.The purpose of this review article is to describe the techniques of solubilization for the attainment of effective absorption with improved bioavailability.

18 September 2012

3 Day National Level Workshop On Computer Aided Drug Designing & Chemoinformatics, 28-30th Sept 2012

RASA Life Science Informatics

Invites you to 3 Day Workshop in In-Silico Drug Discovery and Advance Chemoinformatics (28th-30th Sept. 2012).
Space is limited, so be sure to enroll now!

Salient Features of the Workshop
Workshop groups will study problems with hands-on examples using computational chemistry methods and discuss issues highlighted by examples and Case Studies in drug discovery presented by instructors. A Case Study set with a focus on chemical database creation and filtering drug like compounds will be used to link all workshop activities throughout the workshop.

On completion of this workshop you will be expertise in :
* Hands on training on commercial softwares of Drug discovery
* Application of Chemoinformatics in drug discovery
* Interaction and guidance from eminent scientist & professionals from industry & research labs
* Training from industry expertsfrom Chemoinformatics & drug discovery informatics domain.
* Analyzing chemical fingerprint
* Pharmacophore based Virtual Screening of compounds
* Screening of library compound against selected target
* Analyzing Docking Results
* Molecular Modeling &Dynamics
* Steps involved from Lead Optimization to Final Candidate Drug.
* Generating Knowledge from structure and different chemical databases
* Using various chemical structure drawing and visualization tools
* Digitizing your chemical Data.
* Storing molecules in wide array of format
* Awards for top 2 groups

Speakers:

- Mr.Sameer Chaudhary, MD, RASA Life Science Informatics

- Mr. Rajeev Gangal, Associate Director, Medical Chemistry, Sai Advantium Pharma Ltd

- Mr. Jakir Pinari, Associate Director –DMPK, Sai Advantium Pharma Ltd

- Mr. Priyadarshini Waman Gadade, Sai Advantium Pharma Ltd

- Dr. K.V. Swamy, HOD, Dr.D.Y. Patil Biotech and Bioinformatics

Audience
Graduate/ post-graduate students, professionals, faculties from Organic chemistry, Pharmacy, Bioinformatics, Biotechnology, Agrochemical, Microbiology, Chemical ,life sciences etc from Industries and institutions will benefit the most from getting hands-on experience

Venue:
Alard Charitable Trust
Alard school of Pharmacy, Survey No. 50, Marunje,
Near Rajiv Gandhi IT Park, Hinjewadi, Pune - 411 057,
Maharashtra, India
Tel: 02065600408, 07875692349/7875793891

For any queries contact us at
RASA Life Science Informatics
301, 3rd Floor, Dhanashree Apartment,
Opposite Chittaranjan Vatika, Model Colony,
Shivaji Nagar, Pune - 411016.
Tel: 02065600408, 07875692349/7875793891/8411927535
or email us at workshop@rasalsi.com

14 September 2012

METHOD DEVELOPMENT AND ITS VALIDATION FOR ESTIMATION OF DEFLAZACORT IN TABLET DOSAGE FORM BY UV SPECTROPHOTOMETRY

About Authors:
Kapil Sharma^*1, Subhash Gupta², Priyanka Sharma¹
¹Yaresun Pharmaceutical Pvt. Ltd.,India.
²Oasis test house ltd.
jaipur-302006,rajasthan,india.
*pharma_kapil@rediffmail.com

ABSTRACT
This paper describe a simple, precise and economical spectrophotometric method for the quantitative determination of Deflazacort(DFCT) in tablet dosage form. Method is based on the estimation of DFCT in aqueous acetonitrileat 246 nm. Beer’s law was obeyed in the concentration range of 4-14 µg/ml. The accuracy of the method was assessed by recovery studies and was found to be 99.38±0.15 for DFCT. Results of the analysis were validated statistically so that it can be used for routine analysis of DFCT in tablet dosage form.
11 September 2012

Vertigo Management – Mapping prevalence and treatment. Understanding once a day preparation usage and place in therapy.

About Authors:
Indraneel sinha*, Mr. Sanjay sahai, Mr. Sunil jajoo, Mr. Abhijeet bhatkar
Post graduate diploma in pharmaceutical management,
Indian institute of health management research,
jaipur
*indraneel.sinha.999@gmail.com

COMPANY PROFILE
Sun Pharmaceuticals was set up in 1983 and the company started off with only 5 products to cure psychiatric illness. Sun Pharma is best known worldwide as the manufacture of specialty Active Pharmaceuticals Ingredients (API) and formulations.

However, the company is also concerned with chronic treatments such as cardiology, psychiatry, neurology, gastroenterology, diabetology and respiratory ailments. Active Pharmaceuticals Ingredients (API) includes peptides, steroids, hormones, and anti?cancer drugs and their quality is internationally approved. Mr. Dilip S. Shanghvi is the Executive Chairman and Managing Director of Sun Pharma and Mr. Kamalesh H. Shah is the secretary.
10 September 2012

SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND AMLODIPINE IN RAW MATERIAL AND IN COMBINED TABLET DOSAGE FORM BY RP-HPLC

About Authors:
Kapil Sharma^*1, Subhash Gupta ²
¹Yaresun Pharmaceutical Pvt. Ltd.,India.
² Oasis test house ltd. Jaipur-302006, Rajasthan, India.
*pharma_kapil@rediffmail.com

ABSTRACT
A method for simultaneous estimation of Atorvastatin (ATVS) and Amlodipine (AMLD) in raw material and in combined tablet dosage form has been developed. The method employs the application of RP-HPLC. Chromatgraphy was carried out on a nucleosil C-18,250 x 4.6 mm column using a mixture of phosphate buffer and methanol (50:50 v/v) as the mobile phase at a flow rate of 1.3 ml/min. Run time was 15 min. Detection was done at 245 nm and retention time of ATVS was 6.97 min and 3.96 min of AMLD.³ This method produced linear responses in the concentration range 20-140 µg/ml and 10-70 µg/ml for ATVS and AMLD respectively. The accuracy of the method was assessed by recovery studies and was found to be 100.54± 0.19 and 100.08±0.80 for ATVS and AMLD respectively.The procedure was successfully applied for the simultaneous determination of both drugs in laboratory prepared mixture of raw material and in market available tablet dosage form. Results of the analysis were validated statistically so that it can be used for routine analysis of ATVS and AMLD in combined tablet dosage form.^4-6
29 August 2012

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF TADALAFIL AND DAPOXETINE HCL IN SOLID DOSAGE FORM

About Authors:
CHIRAG S. RAJPARA*¹, JAWED AKHTAR¹, AMIT KHANDHAR²
1. Department of Quality Assurance, School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-302025, Rajasthan, India.
2. Zydus cadila pharma, moraiya,ahmedabad.
*chiragrajpara2601@gmail.com

ABSTRACT
* A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for simultaneous estimation of Tadalafil and Dapoxetine HCL, Water Symmetry C-18 (150 x 4.6 mm),5 µ and a mobile phase composed of Buffer : Acetonitrile (65:35)

* The retention time of Tadalafil and Dapoxetine HCL were found to be10.08 and 4.45 min respectively. Linearity was established for Tadalafil and Dapoxetine HCL in the range of 8.0-60 μg/ml and 24.0-180.0 μg/ml respectively. The percentage recovery of Tadalafil and Dapoxetine HCL were found to be in the range of 99.7-100.6% and 98.07-99.09% respectively. The drug was subjected to acid and alkali hydrolysis, oxidation, dry heat and photolytic degradation. The degradation studies indicated, Tadalafil showed degradation in acid and alkali while it was found stable in H₂O_2,photolytic and in presence of dry heat and Dapoxetine showed degradation in thermal and peroxide while it was found stable in rest of parameters . The degradation products of Tadalafil and Dapoxetine HCL in acidic, alkaline conditions were well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for the quantitative analysis of Tadalafil and Dapoxetine HCL in bulk drugs and formulations.
28 August 2012

RISK OF HYPERTENSION IN DIABETES PATIENT AS COMPARED TO NON DIABETIC

About Authors:
Gupta S^*, Singal A
Apex Institute Of Pharmaceutical Sciences,
Jaipur, Raj., India
*somesh.gupta88@gmail.com

Abstract
The aim of the present study was to correlate the occurrence of hypertension in the diabetics’ patient by the survey report on hypertension associated with diabetics’ patient. The effect of this study is symbolize that 70% patient have diabetes with hypertension and 30% patient with hypertension only so we can say that in this survey as the BGL increased leads to increased in B.P. And it was also found to be that aged patients have more risk of diabetes. Over 60- 70 year age group patient have 40% risk to get diabetes.
7 August 2012

LIPOSOMES: NOVEL DRUG DELIVERY CARRIER

About Author:
Patel Chirag J*, Asija Rajesh, Asija Sangeeta, Mangukia Dhruv
Maharishi Arvind Institute of Pharmacy,
Department of pharmaceutics, Jaipur,
Rajasthan, India.
*chirag.bangalore@gmail.com

ABSTRACT
Amongst the various carriers, few drug carriers reached the stages of clinical trials where liposome shows strong potential for effective drug delivery to the site of action. Liposomes are vesicles having concentric phospholipid bilayers. Molecules from low molecular weight to high molecular weight have been incorporated in liposomes. The water soluble compounds/drugs are present in aqueous compartments while lipid soluble compounds/drugs and amphiphilic compounds/drugs insert themselves in phospholipid bilayers. Drug encapsulated in liposomes include doxorubin, cisplatin, vincristin, melphalan, sarcolycin, daunorubicin, etoposide, etc. The liposomes containing drugs can be administrated by many routes (intravenous, oral inhalation, local application, ocular) and these can be used for the treatment of various diseases. Their predominance in drug delivery and targeting has enabled them to be used as therapeutics tool in fields like tumour targeting, gene and antisense therapy etc. This review discusses the advantages, disadvantages, mechanism, classification, method of preparation, characterization and application of liposomes.
24 July 2012

Juggat Pharma invites for various positions in all major cities of Gujarat, Rajasthan & Madhya Pradesh

Juggat Pharma, Pharmaceutical Division of Jagdale Industries Limited is one of the fastest growing and high performing pharmaceutical marketing company with a global presence based at Bangalore, Karnataka. We provide an ideal environment for highly qualified and committed professionals to pursue their career Under the expansion plan, we are looking for 'Marketing Professionals' in Gujarat/Rajasthan/Madhya Pradesh.
23 July 2012

PREPARATION AND CHARACTERIZATION OF NIOSOMES CONTAINING ACECLOFENAC

About Author:
Patel Sanjay P
Sanjeevan College Of Pharmacy,
Behind Shyam Sarovar Township,
Jaipur-Agra Highway,Dausa-303303,Rajasthan
sanonly4frdz@gmail.com,sanjay_411987@yahoo.com

1.Abstract
Aceclofenac is a drug with narrow therapeutic index and short biological half-life, so can achieve steady state concentration rapidly. This study was aimed at developing and optimizing niosomal formulation of aceclofenac in order to improve its bioavailability as compare to liposomes.This niosome is prepared by modified ether injection technique. In this span 60 & span 20 is used as non ionic surfactants. Different 6 formulation are prepared, In this NFS-1 to 3 formulation are prepared using the span 60 & NFS-4 to 6 are prepared using span 20 along with different proportion of cholesterols. Because of the presence of nonionic surfactant with the lipid, there is better targeting of drugs to tumor, liver and brain. In evaluation study, the effect of the varying composition of non ionic surfactant and cholesterol on the properties such as drug entrapment efficiency, drug content, particle size & shape and drug release were studied. Moreover, the release of the drug was also modified and extended over a period of 72 h in all formulations. NSF-3 emerged as the most satisfactory formulation. Further, release of the drug from the most satisfactory formulation NSF-6 was evaluated through dialysis membrane to get the idea of drug release. The mechanism of dug release was governed by K- Peppas model. In all the niosomes prepared with spans, as the concentration of surfactant increased drug entrapment efficiency increased. Among the spans, span 60 having high phase transition temperature (gel to liquid transformation) and having critical packing parameter (CPP) ranging from 0.5 to 1 entrap drug molecule without any cholesterol. The only drawback of span 60 vesicles was rapid leakage of drug from the vesicle because of high phase transition temperature. In all the cases the best fit model was found to be Peppas with ‘n’ value between 0.65 to 0.73 suggesting the non fickian (anomalous) release mechanism for the drug i.e., erosion followed by diffusion controlled. Formulation NSF-6 showed high entrapment efficiency (96.07%±0.35), particle size (4.22±0.47μm) and drug release (87.21%) over 72 h. Hence it was considered to be good niosomal formulation with greater bioavailability.