Require Senior Research Investigator / Principal Investigator - Discovery Metabolism and Pharmacokinetics (MAP), Pharmaceutical Candidate Optimization (PCO) @ Syngene

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Syngene International is one of India’s premier contract research and manufacturing organizations in providing customized service. Our services encompasses all across discovery chain: early stage discovery, process development, cGMP manufacturing and formulation development both in the small molecule and novel biologics area. Based in Bangalore, Karnataka, the Company is situated in a 90 acre Special Economic Zone with over 100000 sq. mt of built up facilities. The state-of-the-art research facilities have been qualified by various pharmaceutical majors & regulatory agencies.

Post: Senior Research Investigator / Principal Investigator - Discovery Metabolism and Pharmacokinetics (MAP)
Pharmaceutical Candidate Optimization (PCO)

Job Description:
The major responsibility of the selected candidate will be to lead the MAP group, focused on nonclinical pharmacokinetic and metabolism of new chemical entities, in support of various drug discovery programs. He/she will represent the department at all site meetings, and discovery working group meetings, suggest and implement strategies and tactics to address PK/PD/ADME related issues and ultimately enable program decision-making in the selection and advancement of high-quality drug candidates from discovery into development. The incumbent will collaborate with a broad group of scientists in the various PCO department, as well as scientists across various disciplines in the Discovery organization. The individual will play a major role in setting group strategy, vision, and take a lead in key scientific initiatives.

Candidate Profile:
Hands-on experience and in-depth training in the areas of nonclinical pharmacokinetics (PK), pharmaco-dynamics (PD) and/or drug metabolism are required. These include, but not limited to, PK and PK/PD study design and data analysis, drug metabolism concepts and assays, enzyme kinetics, etc. Hands-on experience in conducting in vitro and in vivo studies to assess the ADME of discovery compounds (cell culture, metabolic stability models, CYP inhibition etc.) required. Demonstrated experience supporting lead optimization programs, and preclinical candidate characterization to enable studies towards regulatory submissions like IND is necessary.
Strong problem solving and leadership skills are required. In addition, excellent interpersonal and communication skills (written and spoken) are mandatory in order to perform in a matrix team environment.

Additional Information:
6-10 Years
Location: Bangalore
Education: Ph.D in Pharmaceutical Sciences (e.g. Pharmacokinetics, Drug Metabolism) / Related Discipline
Industry Type: Pharma/ Biotech/Clinical Research
Functional Area:
End Date:
18th Sept., 2011
Job Code: BMP027

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