About Authors: Rinki Verma,
Research fellow,
Banaras Hindu University, Varanasi-221005

Abstract
Cancer is caused by damage of genes which control the growth and division of cells. Detection/diagnose/treatment is possible by confirming the growth of the cells and treated by rectifying the damaging mechanism of the genes or by stopping the blood supply to the cells or by destroying it. Conventional detection method of the cancer is not more efficient than nanotechnogical detection method. Nano Particles (NP) being of a few of nano meters size and the cells being of the size of few microns, NP can enter inside the cells and can access the DNA molecules/Genes and therefore, there is a possibility that the defect in the genes can be detected. The conventional treatment is less sensitive than the nanotechnology methods, certain NP can be designed to absorb preferentially certain wave length of radiation and if they enters in the cancerous cells, they will burn them So, Nanotechnology can be used to create therapeutic agents that target specific cells and deliver toxin to kill them.

Applications are invited for the post of Drugs Controller (India) in the Pay Band-4 (Rs. 37400 - 67000) plus Grade Pay Rs. 10000/- by Deputation [Including short-term contract] from officers under the Central / State Govt. / Union Territories / Recognized Research Institutions / Public Sector Undertakings / Semi-Government / Autonomous / Statutory Organizations:

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Indian Institute of Science Education and Research Bhopal was created in 2008 by the Ministry of Human Resource Development, Government of India. Its mission is to provide quality science education to UG and PG students. The prime focus is to integrate science education and research with a motive of attracting bright students and world class faculty. The Institute is committed to impart high moral and ethical values and create concern for social and environment awareness.

The Government of India, through the Ministry of Human Resource Development (MHRD), and based on the recommendation of Scientific Advisory Council to the Prime Minister, decided to create five undergraduate science universities. One of them is located at Kolkata and was started from 2006.

University of Pune, one of the premier universities in India, is positioned in the North-western part of Pune city. It occupies an area of about 411 acres. It was established on 10th February, 1948 under the Poona University Act. The university houses 46 academic departments.

Glenmark Pharmaceuticals today announced the settlement of litigation with Daiichi Sankyo and Genzyme Corporation regarding Glenmark's Abbreviated New Drug Application (ANDA) tiled with the US Food and Drug Administration (FDA) for Colesevelam Hydrochloride, a drug used in treatment of type-2 diabetes.

About Authors: Manoj Kumar Jadia1*, Dr. U. L. Narayan2
1. Department of Pharmaceutical Chemistry,
Indira Gandhi institute of Pharmaceautical Sciences,
IRC village, Bhubaneswar, Odhisa, India
2. Principal, Department of Pharmaceutical Chemistry,
Indira Gandhi institute of Pharmaceautical Sciences,
IRC village, Bhubaneswar, Odhisa, India

Abstract
The two methods are described for the simultaneous determination of Paracetamol and Etodolac in binary mixture. The first method was based on UV-spectrophotometric determination of both of the drugs, using simultaneous equation method. It involves absorbance measurement at 256.0 nm (λmax of Paracetamol) and 226.0 nm (λmax of Etodolac) in methanol; linearity was obtained in the range of 5 – 25 μg.mL-1 for both the drugs. The second method was based on HPLC separation of the two drugs in reverse phase mode using Promosil C18 column. Linearity was obtained in the concentration range of 30-70μg.mL-1 for Paracetamol and 20-60 μg.mL-1 for Etodolac. The LOD and LOQ value of UV-Spectrophotometric determination was found to be 167.43 ng mL-1, 507.37 ng mL-1  and for HPLC determination was found to be 1653.12 ng mL-1, 5009.48 ng mL-1.Both these methods have beensuccessively applied to pharmaceutical formulation and were validated according to ICH guidelines.

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About Authors: Sharath Babu
M.Pharm, Mallareddy Institute of Pharmacy

Liver Enzymes
Four separate liver enzymes are included on most routine laboratory tests. They are-aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT), which are known together as transaminases; and alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT), which are known together as cholestatic liver enzymes. Elevations of these enzymes can indicate the presence of liver disease.

The Goa Public Service Commission is a body created by the Constitution of India. The Commission advises the Government on all matters relating to State Civil Services referred to it under Article 320 (3) of the Constitution.

Indian Institute of Science Education and Research Bhopal was created in 2008 by the Ministry of Human Resource Development, Government of India. Its mission is to provide quality science education to UG and PG students. The prime focus is to integrate science education and research with a motive of attracting bright students and world class faculty. The Institute is committed to impart high moral and ethical values and create concern for social and environment awareness.

United Biotech has been a trend setter of new standards and is among the fastest growing companies in the Indian pharmaceutical Industry.

The State of Kerala was formed on 1st November 1956 consequent on the Reorganisation of States. It comprises the former Travancore-Cochin State (except the present Kanyakumari District and Shencottah Taluk of the present Tamil Nadu) and the Malabar District and the Kasargod Taluk of South Kanara District of the then composite Madras State.

The National Centre for Cell Science (NCCS) took birth as National Tissue Culture Facility in March 11, 1986 with a mandate of basic research, teaching & training, and as a national repository for cell lines/hybridomas etc.  The centre is located in the midst of academically enriched environment of University of Pune campus, Pune.

The State of Kerala was formed on 1st November 1956 consequent on the Reorganisation of States. It comprises the former Travancore-Cochin State (except the present Kanyakumari District and Shencottah Taluk of the present Tamil Nadu) and the Malabar District and the Kasargod Taluk of South Kanara District of the then composite Madras State.

Indian Institute of Science Education and Research Bhopal was created in 2008 by the Ministry of Human Resource Development, Government of India. Its mission is to provide quality science education to UG and PG students. The prime focus is to integrate science education and research with a motive of attracting bright students and world class faculty. The Institute is committed to impart high moral and ethical values and create concern for social and environment awareness.

About Authors: Aswini K. Reddy, Swetha Yasa, Srivally Challa, Masoom. md
Mallareddy Institute of Pharmaceutical Sciences, Hyderabad

ABSTRACT
Both solid- and liquid-phase combinatorial chemistry have emerged as powerful tools for identifying pharmacologically active compounds and optimizing the biological activity of a lead compound. Complementary high-throughput in vitro assays are essential for compound evaluation. Cell-based assays that use optical endpoints permit investigation of a wide variety of functional properties of these compounds including specific intracellular biochemical pathways, protein-protein interactions, and the subcellular localization of targets. Integration of combinatorial chemistry with contemporary pharmacology now represents an important factor in drug discovery and development.

This is an exceptionally exciting time in the field of pharmacology. The environment for the identification of new therapeutic targets and agents that interact with these targets has rapidly changed with the application of genetic tools and genomics. Extrapolation from the genomic sequencing of lower organisms suggests that there will be a 10-fold increase in the number of potential human therapeutic targets in the next several years with the completion of the Human Genome Project (Drews, 1996). This is leading to a fundamental transformation in pharmacology; no longer is there a dearth of molecular targets for small molecules. Rather, the emphasis is now on validating whether or not the targets are appropriate for therapeutic intervention, on generating large arrays of compounds that represent diverse portions of “chemical space”, and developing methods to quickly assess the credentials of small molecules as target disrupters. We believe many of the tools and reagents that are being developed to facilitate this scientific activity will emerge as vital for future academic pharmacological research. Perhaps most important will be the exploitation of combinatorial chemistry libraries, which are becoming widely available. Although we cannot comprehensively review this broad topic here, the goal of this brief commentary is to portray some of the strategies and potentials of combinatorial chemistry libraries as they relate to pharmacological studies.

The history of Jamia Hamdard begins with the establishment of a small Unani clinic in the year 1906 by Hakeem Hafiz Abdul Majeed, one of the well-known practitioners of Unani System of Medicine of his time. Hakeem Hafiz Abdul Majeed had a vision of making the practice of Unani Medicine into a scientific discipline so that Unani medicines could be dispensed in a more efficacious manner to patients. He gave the name "Hamdard" to his venture which means "sympathy for all and sharing of pain".