About Authors: V.P. Patel^*, M.C. Gohel, R.K. Parikh
*V. P. Patel
M.Pharm, Assistant Professor, R. K. College of Pharmacy, Rajkot, Gujarat, India.
Work was carried out at: Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India
M. C. Gohel
Professor and Principal, Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India
R. K. Parikh
Professor, Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India

Abstract:
With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Other physiochemical and biopharmaceutical properties such as permeability, biopharmaceutics and metabolism are rarely considered during the selection process. The aim of this study was to increase dissolution rate of felodipine poorly soluble drugs from BCS class II by complexation process. Complexation was prepared using β cyclodextrine. Different techniques were employed for preparation of complexation with β cyclodextrin like physical mixture, cogrinding, kneading technology, solvent coevaporation.The physical properties of the prepared solid mass of felodipine was characterized by in vitro dissolution studies, UV- spectroscopy, Fourior transform infrared spectroscopy, differential scanning calorimetry (DSC) and  X-ray powder differaction spectroscopy. Additionaly, phase solubility studies were performed to support the in vitro dissolution study. The results of Fourior transform infrared spectroscopy shows the compatibility of drug with cyclodextrin, while differential scanning calorimetry (DSC) and X-ray powder differaction spectroscopy showed the confirmation of complexation of β cyclodextrin with felodipine.

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February 2011

Walk-in interviews for engagement of Group C Para Medical staff on Contract Basis over Mumbai Central Division of Western Railway for a period up to 30th June 2011 or till availability of regular candidates selected by the Railway Recruitment Board whichever is earlier are scheduled to be held in April 2011 in the Office of the Chief Medical Superintenden

Biocon is a research-driven, global healthcare company with a strong matrix of capabilities along the biopharmaceutical value chain. Focusing on unmet medical needs in cancer, diabetes and inflammatory diseases, it offers novel therapies on a platform of affordable innovation.
Biocon together with group companies employs more than 2500 employees with approxmimately Rs 1,000 crore turnover and is expected to grow further during the current financial year.

About Authors: - Tiwari¹ Bhrigu Narayan*, Mr. Khatri¹ Pankaj, Dr. Ali² Julfikar.
1 . Department of Pharmacognosy Gyan Vihar School of Pharmacy S.G.V. University ,Jaipur (Rajasthan)
2. Department of Biotechnology, School of Science S.G.V .University, Jaipur (Rajasthan)

Abstract
Tissue culture(often called micropropagation) is a special type of asexual propagation where a very small piece of tissue (shoot apex, leaf section, or even an individual cell) is excised (cut-out) and placed in sterile (aseptic) culture in a test tube, petri-dish or tissue culture container containing a special culture medium.Several industries and nurseries have standardized protocols for the multiplication of ornamentals like orchids genera, carnation, roses, chrysanthemum and plantation crop like banana and cardamom.^.The compounds responsible for the memory enhancing effects of Bacopa monniera are triterpenoid saponins called bacosides .In the Ayurvedic Materia Medica, Bacopa has been recognized for its brain enhancement characteristics. Bacopa monnieri, a member of the Scrophulariaceae family, is a small, creeping herb with numerous branches, small oblong leaves and light purple flowers. In India and the tropics it grows naturally in wet soil, shallow water and marches. Brahmi (Bacopa monnieri) (Linn) familyScrophulariaceaeis also known as Madhyarasayana in Ayurveda as it increase mental-clarityand brain stimulating action It also possesses anti-inflammatory, analgesic, antipyretic, epilepsy, insanity, anticancer and antioxidant activities, saponins such as bacosides A, B, C and D which are the active triterpenoid principles and known as "memory chemicals".Only  a  very limited research has been  carried  out  on the plant,  under  the present study  assumes singular  significance and it is supposed to contribute a great deal to the existing literature. The present paper highlights the morphogenic response of various auxins and cytokinins on Bacopa monniera.

About Authors: Ashish Chauhan.
Department of Pharmaceutical Sciences,
Lovely Professional University,
Jalandhar, Punjab.

Abstract:
The essence of essential medicines underlies in satisfying the priority health care needs of the population. The selection of essential medicines is one of the core principles of a national medicine policy as it helps to set primacies for all the aspects of the pharmaceutical system and helps in the maintenance of a proficient healthcare system globally. Devising of essential medicines and national medicine policy is fast emerging as global concept of high relevance to the public irrespective of their nationalities. The prevalence of dreaded diseases like HIV, cancer, and a worldwide upsurge in case of malaria, tuberculosis and other infectious diseases with an addendum problem of multidrug resistance has further augmented the relevance of essential medicines and formulation of a rigid comprehensive national drug policy under the endorsement of WHO medicine strategy andimplementing the same under a complete implementation plan or master plan. This review emphasis the development and selection of essential medicines along with Indian scenario. This review also emphasis the mission, objectives, components, devising and implementation of essential medicine policy along with WHO tenets and regulations.

TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE (THSTI) is an autonomous Institute of the Department of Biotechnology under the Ministry of Science and Technology, Govt. of India. THSTI has been developed as a part of the interdisciplinary Health biotech Science cluster to be located at Faridabad which is a part of the National Capital Region. The Institute is being mentored by globally recognized National Institute of Immunology (NII) and the Harvard-MIT Division of Health Science and Technology (HM-HST). THSTI is designed to be a dynamic and interactive organization with a mission to conduct innovative translational research and develop research collaborations across disciplines and professions to accelerate the development of concepts into tangible products to improve human health. The other members of the cluster include The Regional Centre of Biotechnology (RCB) under the aegis of UNESCO and the NII with which the THSTI will have a seamless collaboration to achieve the interdisciplinary expertise. The cluster will have access to the state of the art experimental animal facility and the platform technology center for the sophisticated instrumentation. The permanent laboratories of the centre will come up in Faridabad within 3 years. The interim laboratories of the centre are functioning from Gurgaon in the South of Delhi area with adequate housing, transportation and schooling facilities. Campus housing may be available when the centre moves to Faridabad.

Vaccine and Infectious Disease Research Center (VIDRC) has been set up as a mission center of the THSTI to study infectious disease and pathogens with the aim to generate translational knowledge for developing prophylactic and therapeutic measures against diseases prevalent in India.

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About Authors:  RAJESH Z. MUJORIYA,
M.PHARM.(PHARMACEUTICS)
Assistant Professor,
sardar patel college of technology, balaghat M.P.

ABSTRACT
Pantoprazole sodium is proton pump inhibitor and used as an antiulcer agent.  The study was undertaken with an aim to formulate pantoprazole sodium enteric coated pellets.
Before going to develop the formulation a detail product literature review was carried out to know about the MUPS and type of dosage form available in market. The present study was focused to formulate delayed release capsule by MUPS Technique.
Average pellets size was determined by sieve analysis and found to be 1680-1200 microns (ASTM sieve no. 12-16). Sieve analysis was the essential step before coating. Because uniform sized pellets undergo effective coating. The result indicates a effective enteric coating and delay the drug release, with 32% acryl ezee solution, is possible. The formulation developed can further be worked on. For identifying a best formulation for delayed release pellets of pantoprazole sodium.

The University of Kashmir is spread over 263 acres of lush green land with three adjacent campuses of exquisite beauty, Amar Singh Bagh, Naseem Bagh and Mirza Bagh. Amar Singh Bagh is located on the bank of the Dal having on its other three sides a background of mountainous amphitheatre rising to a great height above its crystal clear water.

Swami Vivekanand Subharti University is a University under section 2(f) of the University Grant Commission (U.G.C.) Act, 1956 having been setup under the Swami Vivekanand Subharti Vishwavidhaylaya Uttar Pradesh Adhiniyam,2008(U.P.Act No.29 of 2008)as passed by Uttar Pradesh legislature and and assented by the Hon'ble Governer Of Uttar Pradesh in September 2008.

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Established in the year 1978 as an exclusive facility for Small Volume Parenterals (SVPs), Gland Pharma has developed into a progressive and quality conscious organization serving the pharmaceutical needs of diverse markets across the globe.
The Company has world-class & world-scale facilities for injectables set up in collaboration with Vetter Group, Germany. The collaboration with Vetter provides Gland Pharma a technological edge in injectables and specifically in Pre Filled Syringes.