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Development of validated spectrophotometric method for routine analysis of an Ayurvedic formulation, Pancasama Churna

About Authors:
Megha Sharma,
M.Pharma (quality assurance)
Shoolini university of life sciences,
Bhajol, Solan, Himachal Pradesh.
*
meghu35@gmail.com

ABSTRACT:
Traditional medicine, especially ayurveda, is gaining tremendous popularity in modern times due to several reasons. Though, there is still a lack of scientific tests to evaluate the quality, quantity, potency, safety and efficacy of ayurvedic formulations. Need of the hour is to develop simple routine analysis methods to eliminate the problems faced by both practitioners and patients due to sub standard medicines.[4]

Opening for Sr. Executive / Executive - QC, QA, Production (API or Formulations) in Alembic India | Walk in Interviews

Alembic Pharmaceuticals Limited, with an established presence in the Indian pharma industry has a proud, historical track record going back over 100 years. With a turnover in excess of Rs. 1200 crores today. Alembic has been keeping pace with changing times and paradigms. To realize our ambitious plans, we call upon dynamic, result oriented team members to join our API and Formulations manufacturing units.

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Dabur India Limited is a leading Indian consumer goods company with interests in Hair Care, Oral Care, Health Care, Skin Care, Home Care and Foods. From its humble beginnings in the bylanes of Calcutta way back in 1884 as an Ayurvedic medicines company, Dabur India Ltd has come a long way today to become a leading consumer products manufacturer in India. For the past 125 years, we have been dedicated to providing nature-based solutions for a healthy and holistic lifestyle.

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1. Name and number of Post: Senior Research Fellow - One post

A STUDY ON COGNITIVE DYSFUNCTION IN EARLY STAGE OF DIABETES

About Author:
Hiren Sakhiya,
M.Sc in Clinical Research Management,
Prist University, Thanjavur,

India
*sakhiyahiren@gmail.com

ABSTRACT
Diabetes a chronic (lifelong) disease marked by high levels of sugar in the blood. Diabetes is a common disease in older age, affecting about one in five individuals. In 2000, according to the World Health Organization, at least 171 million people worldwide suffer from diabetes, or 2.8% of the population. Its incidence is increasing rapidly, and it is estimated that by 2030, this number will almost double. Diabetes is also associated with mortality and significant morbidity, including neurological disability. Diabetes affects both peripheral nervous system and central nervous system. Neuropathy along with retinopathy and nephropathy appears in late stage of diabetes but effect on cognition starts in early stage of diabetes. Although the effects of diabetes on the peripheral nervous system are well established, the effects of diabetes on the central nervous system have been less clear. Several studies have found that diabetes is related to dementia and cognitive function. It is unclear in which stage of diabetes the cognitive decrements become manifest and how they progress over time. Study is conducted to confirm the association of cognitive function with diabetes.

Pfizer india opens for position as Officer / Executive - Regulatory Affairs

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support.

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Biocon is a research-driven, global healthcare company with a strong matrix of capabilities along the biopharmaceutical value chain. Focusing on unmet medical needs in cancer, diabetes and inflammatory diseases, it offers novel therapies on a platform of affordable innovation.
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A COMPLETE REVIEW ON: EFFLUENT TESTING AND TREATMENT IN PHARMACEUTICAL INDUSTRY

About Authors:
Shashi Kant*,  Dr. Bharat Prashar
Department of Pharmaceutical Sciences,
Manav Bharti University,
Solan (H.P)

*shashi_ranaute@yahoo.in

ABSTRACT:
In this review article, we discussed abouteffluent testing and treatment in pharmaceutical industry,Biological treatment of wastewater is frequently the most beneficial method for selecting various toxic compounds from the environment. Most of the organic compounds in industrial wastewaters are of natural origin and can be degraded by common bacteria in aerobic or anaerobic processes. The composition of these wastewaters is very variable. A great variety of organic chemicals can be determined among the principal components of these types of wastewaters. Antibiotics are the major group of pharmaceuticals. Among all the other pharmaceutical drugs and substances, antibiotics are important compounds due to its serious irreversible increase the release to the environment[1][2][3][4][5]

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Require Pharmacist in SOLAPUR MUNICIPLE CORPORATION

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Indian Institute of Advanced Research will carry out research in the frontier areas of science to contribute towards the advancement of human knowledge and alleviation of human suffering.
To conduct fundamental / applied / analytical research in the frontier areas of science with the ultimate objective of contributing to high quality basic research and human resource development, and to find application of the research results for the benefit of mankind.

FORMULATION AND IN-VITRO CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF CHITOSAN LOADED WITH RAMIPRIL

About Authors:
Yamini Pendyala*, Sudha Talasila, M.sulthana
Department of Pharmaceutics,
Padmavathi College of Pharmacy and Research Institute,
Periyanahalli, Tamilnadu.

*Yamini.pendyala45@gmail.com

ABSTRACT
The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive Ramipril microspheres for its potential use in the treatment of hypertension, myocardial infraction. Ramipril mucoadhesive microspheres, containing chitosan as mucoadhesive polymer and ethyl cellulose as carrier polymer, were prepared by an emulsion-solvent evaporation technique. Preformulation studies were carried out before formulation design. Total seven formulations were prepared.Microspheres were discrete, spherical, free-flowing and showed a good percentage of drug entrapment efficiency. An in-vitro wash off test showed that Ramipril mucoadhesive microspheres adhered more strongly to the gastric mucous layer and could be retained in the gastrointestinal tract for an extended period of time. In-vitro dissolution test was carried out by using phosphate buffer pH 6.8. All the formulations showed good dissolution profiles. Among all the formulation F5 showed good dissolution profile with 81.0% of drug release in 12 hours. In-vitro release kinetic data of Ramipril microspheres showed that the drug release mechanism was diffusion controlled as the plots of Higuichi model was linear. All formulations exhibited Non-Fickian diffusion (n value is in between 0.5 to 1) mechanism. Stability studies were done for the selected formulation indicates that there is no change in drug content of the formulation.The results showed a sustained anti-hypertensive effect over a longer period of time in case of mucoadhesive microspheres, compared to the powder. In conclusion, the prolonged gastrointestinal residence time and slow release of Ramipril resulting from the mucoadhesive microspheres, could contribute to the provision of a sustained anti-hypertensive effect.

URANIUM CORPORATION OF INDIA Invites Pharmacist - Government of India Enterprise

Uranium Corporation of India Limited was incorporated on 4th October 1967. Uranium Corporation of India Limited is a Public Sector Enterprise under the Department of Atomic Energy. UCIL is at the forefront of the Nuclear Power cycle. Fulfilling the requirement of Uranium for the Pressurised Heavy Water Reactors, UCIL plays a very significant role in Indias nuclear power generation programme.

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Work as Head, Regulatory Affairs in Pfizer India

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support.

FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF NIFEDIPINE

About Authors:
*DINESH BABU GOTTIPATI1, SREE DEVI ANANDHAM1, NANNAPANENI VENKATA BALAKRISHNA RAO2.
1 Department of pharmaceutics, M.E.S.college of pharmacy, Aradeshally gate, Bangalore -562110,India.
2 Research and Development Department, Natco Pharma Limited, Kothur.
*babu.dinesh89@live.in

ABSTRACT:
The aim of this study was to evaluate the effect of increasing nifedipine on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension. Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of 43-77%. Sublingual dosage form bypasses the metabolism of the nifedipine in liver and offers a fast relieve from anginal pain and hypertension. An attempt has been made to prepare fast dissolving tablets of nifedipine were prepared by wet granulation technique using Crospovidone and croscarmellose sodium (CCS) as super disintegrants as super disintegrants, Flavor and sweetener impart the taste to the formulation. The porous granules were compressed in to tablets by 8mm punch rotary tablet machine. All the formulations were evaluated for weight variation, hardness, friability, content uniformity, wetting time, and disintegration time and dissolution rate. Among the formulations, F9 one containing to be the best acceptable in terms of palatability, fast dissolving tablet having adequate strength. The disintegration time was found to be 56 ± 0.4 seconds, hardness of 4.6 ± g /cm2, wetting time of 31sec   and drug release of 99.85 % in 9 mins. All the formulations showed low weight variation. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.

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