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ROLE OF HULK PROTEIN- “GRB 10” IN ENHANCEMENT OF MUSCLE MASS: A CLINICAL REVIEW

About Authors:
Mr. Satyanand Tyagi*, Patel Chirag J1, Devesh Kaushik2
*President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic work includes 60 Publications (50 Review Articles, 08 Research Articles and 02 Short Communications of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 60 publications, 11 are International Publications).
He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders, psycho-pharmacological agents as well as epilepsy.
1Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
2Territory Business Manager, Diabetes Division, Abbott Healthcare Private Limited, Okhla, New Delhi, India- 110020.
*sntyagi9@yahoo.com, +91-9871111375/9582025220

ABSTRACT:
A group of Australian researchers at the Garvan Institute in Sydney have conducted a study indicating how Grb10 protein plays a crucial role in increasing muscle mass during development. Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Over expression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.Scientists have discovered a way to build bigger and stronger muscles without having to lift a finger.

TRANSDERMAL PATCHES: A REVIEW

About Authors:
Patel Chirag J1*, Satyanand Tyagi2, Patel Jaimin1
1Maharishi Arvind Institute of Pharmacy, Department of Pharmaceutics, Jaipur, Rajasthan.
2President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India.
*chirag.bangalore@gmail.com, +918000501871

ABSTRACT:
Now a day about 74% of drugs are taken orally and are found not to be as effective as desired either due to bioavailability problems or degradation of drug in acidic pH of stomach. To resolve such problems, transdermal drug delivery system (TDDS) was emerged. Transdermal drug delivery systems are dosage forms involves drug transport to viable epidermal and dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. Transdermal drug delivery systems, also known as ‘‘patches,’’ are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. This review article provides an overview of TDDS, advantages, limitations, various components of TDDS, methods of preparation, types of transdermal patches, factors affecting transdermal permeation, evaluation parameters and new approaches in TDDS.

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Railway Recruitment Board -Mumbai invites Pharmacist-II - 16 Vacancies

Railway Recruitment Board (RRB), Mumbai functions under the Ministry of Railways, Government of India. It is primarily responsible for recruiting the group 'C' staff.

PROBLEM: ENVIRONMENTAL POLLUTION AND GLOBAL WARMING IDEA TO IMPLEMENT GREENERY IN INDIA

The main problem which we are facing is the Global warming because of the polluted atmosphere. My idea can reduce the global warming and can bring back the polluted free environment

MAIN OBJECTIVE:
Converting the brown economy to green economy can be done very easily and fastly only by the Indian youth by starting an effective campaign by name “earth warriors” or some other easy feasible name so that everyone in India can understand the theme of the program easily unlike the other programs that we had earlier like great power race or carbon credit race etc., which takes time for the people to understand the theme of the campaign.

Job as Executive in Finition Solutions | 5 Posts

With the bricks of inveterate faith in ourselves was laid the foundation of Finition Solutions, Rising from a small Consulting company that planted its roots in the Nawabs or pearl City Hyderabad / India, Finition Solutions has grown over the years into a dynamic medium-sized business activities spanning through India, UK and USA.
Finition Solutions is involved in businesses as diverse as HR Services, Information Technology, Manufacturing and Bio (Environmental Solutions).

PREPARATION & EVALUATION OF MICROSPHERES OF DICLOFENAC SODIUM BY SURFACE ACTIVE AGENT SLS

About Authors:
*Kalpesh Ashara, Jignesh Solanki
B.K.Mody Govt.Pharmacy College Rajkot,
Department of Pharmaceutics,GTU, Gujarat, India.
*kalpeshshr5@gmail.com

Abstract:
Microspheres are solid spherical particles containing a dispersed drug in organic solution fall in a range of 1-1000mm. Microspheres or micro particles are monolithinic device refer to a rate controlling matrix throughout the drug is dissolved or dispersed, while microcapsules are device which consists of cell-like dosage forms with the drug contain within the rate controlling membrane. Microspheres are prepared by several methods. Here Microspheres are prepared using a surface active agent SLS. Then Evaluation of Microspheres is carried out by means of several parameters. Then concluded that the diclofenac: polymer ratio of 1:2 & organic solvent (MeOH: DCM) ratio of 1:4 was found to be optimum for spherical shape of microspheres as well as Practical Yield.

PREPARATION OF VILOXAZINE SUSTAINED RELEASE DRUG DELIVERY SYSTEM BY USING ETHYLCELLULOSE, CARBOPOL, SODIUM ALGINATE, HYDROXY PROPYL METHYL CELLULOSE & GUAR GUM

About Authors:
D. HariHaran*, M. Senthil kumar, M. Ashok Kumar, S. Dinesh & R.Jenish.
Annai Veilankanni’s College of Pharmacy,
81, V.G.P. Salai, Saidapet, Chennai-600015.
*haran_pharma@yahoo.com

ABSTRACT
The present study behind this work is to find to prepare sustained release tablets of Viloxazine by compression method. First of all to formulate Viloxazine sustained release tablets using the Ethylcellulose, Carbopol, Sodium Alginate, Hydroxy propyl methyl cellulose & Guar gum under ratio’s  like 1:1, 1:1, 1:1,1:1,1:1 . Five batches were made in various polymers of ethylcellulose, carbopol, sodium alginate,hydroxy propyl methyl cellulose & guar gum is used by keeping the drug as constant. Then evaluation of Viloxazine sustained release tablets was carried out for characteristics like drug content in tablet, UV analysis. In vitro release starts from 1hr and up to 24hrs. It shows the percentage of gradual drug release as 17.80%, 27.65%, 35.12%, 45.16%, 51.20%, 57.42%, 61.30%, 66.32%, 72.08%, 77.15%, 81.32%, 84.48% & 98.20% against the label claim as 40mg.

Opening in Contractual Scientist - Pharmacy/Pharmaceutical Chemistry/Analytical Chemistry , SRF and JRF in GBPUAT - 5 posts

Applications are invited for the posts of PDF (Contractual Scientist), Senior Research Fellow (SRF) and Junior Research Fellow (JRF) in the Institute of Biotechnology, G.B. Pant University of Ag. & Tech., Patwadangar (Nainital). The monthly emoluments and qualifications for the above posts are as follows:

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The National Institute of Biologicals invites Scientist Grade-I, II and Jr. Scientist - 3 Posts

The National Institute of Biologicals, an autonomous institution under the Ministry of Health & Family Welfare, Government of India is a premier scientific organization and a Centre of excellence to ensure quality of vaccines and biologicals in the country. Applications are invited for the following scientific posts on Direct recruitment basis.

Applications are invited through Walk-in-Interview for project on Autoimmune markers in NIRRH

National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai. Since its inception in 1970, it has been making vigorous efforts to improve the reproductive health of people through research, education and health care services.

Require Sales/Marketing Executive in Aspiring-Solutions

Leading company specialized in Medical Equipment, Electronic Weighing and Corporate Promotional Products located in Mumbai. Our client  is an ISO certified company and broadly caters to three categories – Medical Equipment, Electronic Weighing and Corporate Promotional Products. our client has their own manufacturing facilities at Rabale, Navi Mumbai with in-house R&D, Design and Production.

CONTRACT MANUFACTURING AND THEIR AUDITING

About Authors:
Arshad Hala*, Prof. Rajesh Dholpuria, Nilesh Sovasia
1Seth G. L. Bihani S. D. College Of Technical Education,
Institute Of Pharmaceutical Sciences & Drug Research,
Gaganpath, Sri Ganganagar, Rajasthan 335001
*Arshad_hala@yahoo.com

1. INTRODUCTION:-
1.1. Origin:-

Contract manufacturing is defined as the manufacture (or partial manufacturer) of a product to the order of one person or organization (the contract giver or customer) by another independent person or organization (contract acceptor or principle manufacturer). Manufacture in this context is identified as the act of processing or packaging a medicinal product or device to a given specification.(Shah, D.H., 2000)

Contract manufacturing should be consideration as an extension of the principal manufacturer’s operation. Consequently the principal manufacturer should require the same standards of good manufacturing practices (GMP) for a contractor’s operation as he would his own. In addition, the customer must ensure that the principle manufacturer holds the relevant legal authorizations for the work to be carried out.(Shah, D.H., 2000)

The responsibility and activities undertaken by each party need to be clearly stated in a formal agreement, separate from but additional to the legal business contract formed by the placement of an order. Commercial matters need to be appreciated as being distinct from technical matter and need to be detailed separately with due consideration for compliance with local legislation.(Shah, D.H., 2000)

NOVEL SUSTAINED RELEASED DRUG DELIVERY: A MODERN REVIEW

About Authors:
Patel Chirag J1*, Satyanand Tyagi2
1Maharishi Arvind Institute of Pharmacy, Department of Pharmaceutics, Jaipur, Rajasthan.
2President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India.
*chirag.bangalore@gmail.com, +918000501871

ABSTRACT
The basic rationale of sustained release drug delivery system optimizes the biopharmaceutical, pharmacokinetic and pharmacodynamic properties of a drug in such a way that its utility is maximized, side-effects are reduced and cure of the disease is achieved. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased safety margin of potent drug, reduction of fluctuation in steady-state drug levels, reduction in healthcare costs through improved therapy and shorter treatment period.Presently pharmaceutical industries are focusing on development of sustained release formulations due to its inherent boons.Wide varieties of polymers are available for retarding the release rate of drugs hence sustains the action of drugs. This article contains the basic information regarding sustained-release formulation, its advantages, different types, and characteristics involved in oral sustained-release dosage form design.

Require Drug Inspector, Senior Analyst, Junior Analyst, Lecturer of Pharmacy / State Polytechnic in UKPSC

UKPSC invites to fill up opening in group B and C, which is mentioned as below. No. of vacancies may increase or decreased.

Post: Drug Inspector, Senior Analyst, Junior Analyst, Lecturer of Pharmacy / State Polytechnic

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Work as Trainee in GVK Biosciences - 12 posts | B. Pharm, M. Pharm, Final Year M.Sc & BE/B.Tech, ME/M.Tech

bioCampus, GVK Biosciences is leading Informatics Services provider with wide range of Products and Services across the R&D value chain.

Job as Senior Research Fellow in Indian Institute of Advanced Research

Applications are invited for the position of SRF in ICMR sponsored project: "The study of mitochondrial dynamics during S aureus infection in human epithelial cells" with Dr. Rajesh Singh, Assistant Professor, Cell Biology Group, IIAR.

Post: SRF (One post)

CSIR- OSDD Short Video Competition on “The Need of New Drugs for Tuberculosis”

CSIR- OSDD with Vigyan Prasar is conducting a YouTube based short video competition on "The Need of New Drugs for Tuberculosis". All individuals, including students above 18 years of age, educational institutions and organizations are invited to participate in the contest, and win attractive prizes !!!

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BREAST CANCER: AN OVERVIEW

About Authors:
Amardeep Sharma
Rathi Orthopaedic & research centre,
Ahmedabad, India
amardeep.sharma54@gmail.com

{ DOWNLOAD AS PDF }

ABSTRACT:-
The knowledge of breast cancer development and progression has grown in recent years and relatively development of novel therapeutic strategies, but for cancer mortalities in women breast cancer stands at 2nd position as cause.
In U.S. Approximately 39970 women & 450 men in the U.S. will be diagnosed from the disease in 2011.[1] Breast cancer is a hormone dependent disease.[3] Breast cancer occurs when breast epithelial cells grows in abnormal way. HER2/neu, ER, PR, BRCA1, BRCA2 are the well known influencing factors responsible for breast cancer initiation. The major issues that limit the currently available breast cancer treatment are high cost, poor availability and resistance to chemotherapeutic agents. To overcome this problem researchers are working on several novel approaches i.e. “Novel drug targets & Novel target therapies”.

Since from past few years, mammogram is playing a huge role for decreasing incidence rate in developed countries. Breast cancer is adversely affecting the “quality of life” of patients and its impact has been increasing on the Social capital, population structure and economic growth. Need for novel anti breast cancer agent and novel early diagnosis technique is necessary to combat one of the most serious crises facing Human development.

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