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Use of the Liquisolid Technique for Improvement of the solubility and Dissolution of Clozapine

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PharmaTutor (September- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 9)


Received On: 30/06/2014; Accepted On: 02/07/2014; Published On: 01/09/2014


AUTHORS: Gadhavi Aakash Vijaykumar*, Jaimin Kapadiya, Jitendra Patel, UM Upadhyay
Department of Pharmaceutics,
Sigma Institute of Pharmacy, Vadodara, Gujarat, India


The aim of the present work was to enhancement of Solubility and Dissolution of Clozapine using liquisolid technique. This work aimed to study the effect of different liquid vehicles on release characteristics of Clozapine. For liquisolid technique, different amount of liquid and ratio of carrier to coating material were employed. Avicel PH 102 and Aerosil 200 were used as carrier and coating material respectively and sodium starch glycolate (5%) was used as superdisintegrant. The empirical method as introduced by Spireas and Bolton 1999 was applied strictly to calculate amount of carrier and coating materials required to prepare liquisolid tablet. Quality control test like uniformity of tablet weight, uniformity of drug content, hardness, friability test, disintegration test and in-vitro dissolution tests were performed to evaluate the each batch of prepared tablets. In vitro drug dissolution profile of the liquisolid formulation were studied and compared with the Directly Compressed tablet of Clozapine in 0.1N HCL. Stability study was carried out to evaluate the stability of the tablet under humid condition. It was found to be that the optimized liquisolid tablet has high dissolution efficiency (80.44%) and lower mean dissolution time (MDT).From present study it can be concluded that liquisolid technique shows better improvement in solubility and dissolution of Clozapine than the pure drug.


How to cite this article: AV Gadhavi, J Kapadiya, J Patel, UM Upadhyay; Use of the Liquisolid Technique for Improvement of the solubility and Dissolution of Clozapine; PharmaTutor; 2014; 2(9); 101-114