History of Cationic vs Anionic: in nasal drug delivery system
PharmaTutor (May- 2014)
ISSN: 2347 - 7881
Received On: 08/03/2014; Accepted On: 23/03/2014; Published On: 01/05/2014
Author: Manu Sharma1, Shikha Chaudhary1, Dharmendra Kumar2*
1R.V.Northland institute, greater Noida, Dadri, UP, India
2Brahmanand Group of Institution, Khurja G.T Road, Buldshahar, Uttar Pradesh, India.
Chitosan as cationic and pectin as anionic are natural polysaccharides which show great potential in nasal drug delivery system. Chitosan’s are strongly poly-cationic. They are derivatives of poly-N-acetyl-D-glucosamine. Chitosan’s have positive charge that is responsible for mucoadhesion and play an important role in nasal drug delivery system Pectin’s have several structural elements: Homogalactouronan are smooth and Rhamnogalactouronan are hairy which play a very important role. By methyl esterifications, pectin’s are divided in two types: High methoxypectin’s and low methoxypectin’s. Low methoxypectin’s are very important in the formulation of nasal gel, because they have properties to form the gel with calcium ion (Ca2+).
How to cite this article: M Sharma, S Chaudhary,D Kumar; History of Cationic Vs Anionic: in nasal drug delivery system; PharmaTutor; 2014; 2(5); 104-107