Dendrimer: A Novel System in Pharmaceuticals
PharmaTutor (January- 2014)
ISSN: 2347 - 7881
Received On: 21/12/2013; Accepted On: 07/01/2014; Published On: 15/01/2014
About Authors: Abhishek Shah*, Gautam Singhvi
Department of Pharmacy, Industrial Research Lab,
Birla Institute of Technology and Science,
Pilani, Rajasthan, India.
ABSTRACT: Dendrimers are a new class of synthetic polymers which have a tree or star shape like structure, with a central core, interior branches and terminal groups which embellish the surface. It can be synthesized by a repetitive step-growth polymerization process. They are highly branched and monodisperse macromolecules. The structure of dendrimers mainly affected to its physical and chemical properties; so, it is widely used in biomedical, pharmaceuticals and industrial applications. In Drug delivery system, dendrimer plays major roles in ophthalmic, topical, transdermal, targeted drug delivery since last decade. Recent progress has been made in the application of biocompatible dendrimers to cancer and AIDS treatment, including their use as delivery systems for potent anticancer drugs such as cisplatin and doxorubicin, as well as agents for both boron neutrons capture therapy and photodynamic therapy. It is alsoinhibiting the entry of HIV and herpes simplex virus (HSV). This review articles giveswhole idea about various dendrimers, its type and its properties. Also it considers brief idea about various dendrimers used in various areas of research, treatment and diagnosis.
How to cite this article: A Shah, G Singhvi, Dendrimer: A Novel System in Pharmaceuticals, PharmaTutor, 2014, 2(1), 83-97