Nanocochleate: Novel Bypass of Conventional Drug Delivery System
PharmaTutor (February- 2014)
ISSN: 2347 - 7881
Received On: 26/12/2013; Accepted On: 02/01/2014; Published On: 10/02/2014
Author: Harsh Vyas, Tulsi Upadhyay, Nirali Thakkar, Kruti Patel, Umesh Upadhyay
Sigma Institute of Pharmacy,
Bakrol, Vadodara, Gujarat, India
ABSTRACT: Nanocochleate is a novel lipid based drug delivery system offering systemic and oral delivery of various charged drug molecules. It is formed by negatively charged lipid bilayer. Nanocochleate can encapsulate drugs which are hydrophobic, positively charged, negatively charged and poor orally bioavailable. It is also very much beneficial for oral absorption for peptide drugs that possess a net positive charge. Nanocochleate is beneficial for molecules having binding sites inside the cell. The property that nanocochleates can facilitate cross membrane diffusion for charged and impermeable molecules finds wide application in drug delivery. Nanocochleate have been proven better than liposomes and more compatible with body environment. They differ from liposomes by its structure and compatibility to the body. Liposomes are lipid bilayer with aqueous inner environment and unlike liposomes nanocochleates are having charged lipid bilayer without aqueous environment and are multilayer lipid matrix i.e. Cochleate.
Various methods of its formulation, structure, merits demerits and wide range of application are described in this article.
How to cite this article: H Vyas, T Upadhyay, N Thakkar, K Patel, U Upadhyay, Nanocochleate: Novel Bypass of Conventional Drug Delivery System, PharmaTutor, 2014, 2(2), 90-97