Skip to main content


Magazine HomeEditorial BoardLatest IssuesAuthor GuidelinesContact Us

April 2018 ARTICLE LIST >>

PharmaTutor (April - 2018)


ISSN: 2347 - 7881
(Volume 6, Issue 4)


Received On: 08/01/2018; Accepted On: 27/01/2018; Published On: 01/04/2018


JY Manure*, NS Naikwade, PJ Shirote, SA Bagwan, KM Kulkarni
Department of Pharmaceutical Chemistry,
Appasaheb Birnale College of Pharmacy,
Sangli, Maharashtra, India.



A new crystal form of 10-Propargyl-10-Deazaaminopterin, form SL, was discovered which is thermodynamically stable, shows long term stability and is applicable for using in final dosage forms. Form SL was characterized by several analytical methods such as thermal analysis by DSC, IR, X-ray powder diffraction, SEM (Scanning Electron Microscopy), Digital optical microscopy and solubility/dissolution measurements. Active pharmaceutical ingredients should be stable during technological processes for the preparation of a final dosage form and must also remain stable during storage. The morphology of long needle and plate shaped crystals was investigated by scanning electron microscopy (SEM) and optical microscopy. Form SL was compared to other forms of 10-Propargyl-10-Deazaaminopterin such as form A, B, C and to the amorphous form. The thermodynamic stability of form SL is supported by its long-term stability. Form SL is a pharmaceutically applicable crystal form.



How to cite this article: Manure JY, Naikwade NS, Shirote PJ, Bagwan SA, Kulkarni KM; A New Types of Polymorphic Form of 10-Propargyl-10-Deazaaminopterin, from SL: As a Refractory Peripheral T-cell Lymphoma Drug; PharmaTutor; 2018; 6(4); 45-50;