• PharmaTutor
    23 July 2013

    WAFERS TECHNOLOGY – A NEWER APPROACH TO SMART DRUG DELIVERY SYSTEM

    ABOUT AUTHORS:
    Papola Vibhooti *, Dr. Kothiyal Preeti
    Shri Guru Ram Rai Institute of Technology & Sciences
    Dehradun, Uttarakhand, India
    *papola.vibhooti47@gmail.com

    ABSTRACTS
    The lyophilized wafer developed throughout this review is an effective and versatile drug delivery system for oramucosal application. This has been established from the extensive physicochemical and physic mechanical profiling conducted. Through a screening and selection of polymers, HPC had the lowest gelation characteristics and was therefore suitable for the development of the wafer system. Suitable excipient and polymer combinations were established which allowed for the development of rapidly disintegrating and prolonged release wafer systems. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin, carmellose and gelatin, provided effective release of model drug diphenhydramine hydrochloride over approximately six hours. The modification of this technology to provide a prolonged release mucoadhesive system seems promising. It is envisaged that this system will be applicable to many drugs requiring the extended release of bioactive material. Therefore, the lyophilized wafer matrices developed in this study are highly effective in the rapid delivery of drugs, using the oral route as a site of administration.

  • 23 July 2013
    FUTURE ASPECTS IN DENGUE FEVER THERAPY

    Dengue fever is a viral caused disease that is spread by the bite of mosquito Aedes aegypti. There are 4 distinct, but closely related, serotypes of the virus that cause dengue (DEN-1, DEN-2, DEN-3 and DEN-4)

    Symptoms

  • 22 July 2013
    DESIGN, DEVELOPMENT AND OPTIMIZATION OF OLMESARTAN MEDOXOMIL LIQUISOLID TABLETS USING CENTRAL COMPOSITE DESIGN

    ABOUT AUTHORS:
    Swati k. Nagar*1, Dr. Harsha V. Patel1, Dr.Vishnu A. Patel2, Vinod V. Siju3
    1Indukaka Ipcowala College of pharmacy, New V.V.Nagar
    2ARCP, Vallabh vidhyanagar
    3Anand Pharmacy College, Anand.
    *swati.nagar28@gmail.com

  • 22 July 2013
    A REVIEW ON THE BIOLOGICAL ACTIVITIES OF 1,3,4- OXADIAZOLE

    About Author:
    Alex Martin
    Department of Pharmaceutical Chemistry,
    St. Joseph’s College of Pharmacy
    University of Health Sciences, Cherthala-688524 (Kerala), India.
    aalexmartin@rediffmail.com

    Abstract
    Oxadiazole is a five membered heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. It exists in four isomeric forms. One of its four isomers 1,3,4-oxadiazole exhibited  a wide range of biological activities which includes anti-bacterial, anti-tubercular, anticonvulsant, hypoglycemic, anti-allergic, enzyme inhibitor, vasodilatory, antifungal, cytotoxic, anti-inflammatory, analgesic, hypolipidemic,  anticancer, insecticidal activities etc. The present review has basic information about 1,3,4-oxadiazole and its biological activities.

    Oxadiazoles is a heterocyclic ring and is considered to be derived from furan by the replacement of two methane (-CH=) groups by two nitrogen (-N=) atoms. There are four possible isomers of Oxadiazole, depending on the positions of hetero atoms  and they are named as 1,2,3; 1,2,4; 1,2,5; 1,3,4-oxadiazoles. 1,2,4-Oxadiazole, 1,2,5-Oxadiazole, and 1,3,4-Oxadiazole are known, but the 1,2,3-isomer is unstable and reverts to the diazoketone tautomer. The stable oxadiazoles appear in a variety of pharmaceutical drugs including raltegravir, butalamine, fasiplon,  oxolamine, and pleconaril.

  • 21 July 2013
    COLON TARGETED DRUG DELIVERY SYSTEMS: A REVIEW

    ABOUT AUTHORS:
    P.Ramaa Bharathi*, Dr A.M.S.Shdhakar Babu
    Department of Pharmaceutics,
    A.M.Reddy Memorial College of pharmacy, Narasaraopet,
    Guntur (Dt), Andhra Pradesh, India.
    *puluguramabharathi63@gmail.com

  • 21 July 2013
    PREPARATION AND CHARACTERIZATION OF NAPROXEN SODIUM AGGLOMERATES BY SPHERICAL CRYSTALLIZATION TECHNIQUE

    About Authors:
    Akash M Patel*, Jitul B Patel
    *Faculty of Pharmacy, Dharmsinh Desai University,
    Nadiad-387001, Gujarat
    *aku.pharmacy@gmail.com

  • 19 July 2013
    PREPARATION AND CHARACTERIZATON OF ACECLOFENAC LOADED TOPICAL EMULGEL

    ABOUT AUTHORS:
    Sharma Devendra L.*1, Dr. A.K.Seth1, Nirmal Shah1, Sachinkumar P Chauhan, Chintan Aundhia
    1Department of Pharmacy, Sumandeep Vidyapeeth University,
    At & Po Pipariya, Ta.- Waghodia, Dist. Vadodara-391760.
    (Gujarat) India
    *9009dev@gmail.com

  • 19 July 2013
    DEVELOPMENT AND METHOD VALIDATION OF BACLOFEN BY RP-HPLC IN BULK DRUG AND PHARMACEUTICAL FORMULATION

    ABOUT AUTHORS:
    *Kamaldeep singh, Gurvinder Pal Singh, Sandeep Kumar Sharma
    Adesh Polytechnic College,
    Sri Muktsar Sahib 152026 (Punjab)
    *kamalmehta86@yahoo.com

  • 18 July 2013
    NIOSOMES- AS NOVEL DRUG DELIVERY SYSTEM

    ABOUT AUTHOR:
    Deepika Kadodiya
    Mahakal Institute Of Pharmaceutical Studies,
    Ujjain M.P.
    deepikakadodiya05@gmail.com

  • 17 July 2013
    CARCINOGENICITY TESTING

    ABOUT AUTHOR:
    Jitendra kumar
    M.S. Pharmacology & Toxicology
    NIPER raebareli
    jkumar.kumar382@gmail.com

    INTRODUCTION
    This chapter presents an historical overview of cancer, carcinogenicity testing, and human cancer causes. Cancer has been known for a very long time, but the awareness of human carcinogenicity caused by chemicals is a phenomenon of the 20th century. This in turn has produced legislation that prohibits the use of carcinogens in the food chain and has provided guidelines for carcinogenicity testing in animals. Lifetime studies (18–24 months) in two main rodent species (rat and mouse), also known as the “Standard Chronic Bioassay,” have been conducted since the 1960s

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