Articles

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ABOUT AUTHOR:
Balram Soni*
Psychiatric Centre, S.M.S. Medical College,
Jaipur, Rajasthan, India
brpharma@rediffmail.com

ABSTRACT
Benzimidazole derivatives have shown hopeful activity in the treatment of several diseases, for this reason, the synthesis of novel benzimidazole remains a main focus for researchers. This review article summarizes the chemistry of different derivatives of benzimidazole along with their biological activities. The review article also covers the most active benzimidazole derivatives that have shown considerable pharmacological actions.

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ABOUT AUTHORS:
Mohalkar Rahul¹*, Poul Bhagwat², Patil S.S¹, Shetkar M.A¹, Dilip Chavan^1
1 Department of Quality Assurance, Maharashtra College of Pharmacy, Nilanga
² Principal of Maharashtra College of Pharmacy, Nilanga,
Latur, Maharashtra, India.
*rahulmohalkar@gmail.com

ABSTRACT:
The oral drug delivery system which includes the solid dosages form such as conventional dosages form and immediate release dosages form. Form last several decades conventional dosage forms like capsule, solid, pills, powder, solution, emulsion, suspension aerosols are used in the various treatments of acute or chronic disease. Today this formulation can be considered as primary pharmaceutical product are mostly seen in overalls market. Tablet is most popular among the all dosages forms today and recently found mostly accepted tablet dosages forms. Because of its convenience easy to administration, convenience of self administration, compactness and easy for the manufacturing. In number of cases immediate onset of action is required than conventional therapy. The basic approach used in development immediate release solid dosages form by using superdisintegrant like sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (PVP) etc. which provides in instantaneous disintegration of tablet after administration. By using various techniques in can be formulate like wet granulation, direct compression etc. Hence its having A new dosage form allows a manufacturer to extend market exclusivity, while offering its patient population a more convenient dosage form or dosing regimen.

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ABOUT AUTHORS:
K.Charan
A.U.College of Pharmaceutical Sciences,
Waltair, Visakhapatnam, Andhra Pradesh, India.
charan.karumuri@gmail.com

ABSTRACT
The present study was designed to screen anti-depressant activity of Hydro alcoholic extract of Triticum Aestivum using Chronic models (14 day study) of Tail suspension test (TST) and Forced Swim Test (FST) in Swiss Albino rats. Wheat grass were collected and authenticated. Extraction of dried wheat grass was carried out using a Soxhlet apparatus to obtain its Hydro alcoholic extract. The extract of Triticum Aestivum showed the significant anti-depressant activity comparable to the standard drug. The oral administration of Triticum Aestivum extract at doses 200 mg/kg & 400 mg/kg respectively as compared to the control treated group showed an anti-depressant activity comparable to that of standard drug.
The anti-depressant effects of Triticum Aestivum extract seem to be mainly associated with the activation of dopaminergic system and possess potential anti-depressant activity.