Articles

  • PharmaTutor
    25 September 2015

    BIOCHEMICAL STUDIES OF AQUEOUS EXTRACTS OF MANGIFERA INDICA (LINN) ON THE LIVER OF PLASMODIUM - INFECTED ALBINO MICE

    ABOUT AUTGHORS:
    *Olayode, Ahmed A1; Ofusori, David A1; Ogunniyi, Titus A. B2; Saka, Olusola S1; Ajayi, Olusoji C3; Adewole, Oluwole S1
    1Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
    2Department of Medical Microbiology and Parasitology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
    3Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
    *olayodeahmed01@gmail.com

    ABSTRACT
    This study was carried out to assess the biochemical effects of Mangifera indica on the liver function enzymes of Plasmodium – infected albino mice. Forty-two male Swiss albino mice, weighing between 20 and 25 g, were used for this research. The mice were randomly assigned into six groupsA, B, C, D, E and F of seven mice each. Groups B, C, D, E and F were infected with Plasmodium berghei. Group A was the negative control, group B was positive control. Mice in groups C, D and E were orally administered with Mangifera indica(MI) extract (50 mg/kg, 100 mg/kg and 150 mg/kg body weight) respectively for 5 days starting from the 4th day of inoculation while mice in group F were orally administered with Artesunate for 5 days (3 mg/kg body weight on the first day and 1.5 mg/kg body weight for the next 4 days) starting from the 4th day of inoculation. The animals were left for another 14 days after treatment. Blood samples, collected through cardiac puncture, were centrifuged to obtain sera. Activities of ALT, AST and ALP as well as bilirubin concentration were measured from the sera using enzyme colorimetric methods. Dataobtained were analyzed using descriptive and inferential statistics. Mangifera indica extract has an ameliorative effect on the serum level of total bilirubin concentration but appeared to be less effective in reducing the activities of the liver function enzymes.

  • 21 September 2015
    STUDY ON AGARWOOD (AQUILARIA MALACCENSIS) TO EVALUATE ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF N – HEXANE, CHLOROFORM AND ETHYL ACETATE EXTRACTS

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  • 20 September 2015
    THERAPEUTIC POTENTIAL OF TRITICUM AESTIVUM LINN. (WHEAT GRASS OR GREEN BLOOD THERAPY) IN THE TREATMENT AND PREVENTION OF CHRONIC AND ACUTE DISEASES: AN OVERVIEW

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  • 14 September 2015
    EFFECT OF PULSATILLA ON POLYCYSTIC OVARIAN SYNDROME AND ITS ASSOCIATED CANCER

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    ABOUT AUTHORS:
    Debpratim Chakraborty
    Persuing M.Pharm (Pharmacognosy),
    Jadavpur University, West bengal.
    debpratim008@gmail.com

    ABSTRACT
    Polycystic Ovarian Syndrome is one of the most common female endocrine. Many papers reported the correlation between infertility that most eminently predisposes towards cancer in PCOS women from many years. From both clinical and experimental research one can conclude that correlation between PCOS and endometrial cancer is the strongest. Most studies on correlation between PCOS and ovarian cancer as well as breast cancer failed to show a link though Pulsatilla have a strong effect on it. Various synthetic drugs which mainly used in the treatment of PCOS and endometrial cancer but here the problem is those drugs has lots of side effect/Adverse effect so we should go with the natural product Pulsatilla Sp. Which is used on PCOSand various cancer. Pulsatilla is a well establish drug for PCOS with unknown mechanism of action. Deoxypodophyllotoxin, which was isolated from the roots of P. koreana, was found to inhibit the tube-like formation of HUVECs (human umbilical venous endothelial cells) and have a potent antitumor effect. The chemical constituent saponin D present in Pulsatilla root is responsible for the anti tumor activity. The results, which are expressed as Pulsatilla saponin D has such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). 23-Hydroxybetulinic acid synthesized from Pulsatilla chinensis also shows anti tumoral activity. Though the potency of pulsatilla sp. Are less than synthetic marketed drugs but by structural modification we may get potent anti canceral agent with least toxicity by Pulsatilla.

  • 13 September 2015
    BIODEGRADABILITY AND WASTE MANAGEMENT OF JAIPUR FOOT

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    ABOUT AUTHORS:
    Anil Kumar Jain1*, Mona Kejariwal2
    1 Dr. P.K. Sethi Rehabilitation Centre, Santokba Durlabhji Hospital, Jaipur, Rajasthan, India
    2Department of Botany, R.D. National and W.A. Science College,  Bandra (west), Mumbai, India.
    *anil.rehab64@gmail.com

    ABSTRACT
    Designed in and named after Jaipur, India, the prosthetic foot was designed to be inexpensive, water-resistant, and quick to fit and manufacture. Several field trials case studies were made and this artificial aid was found to be very comfortable and acceptable to the amputee population following floor sitting culture.  The quality assertion and standards related to these prostheses at affordable cost assume great significance especially for India and other developing countries. Environmental issues such as biodegradability of various components like microcellular rubber, tread rubber, nylon cord, cushion compound and skin colour rubber and other. It is necessary that biodegradation issues should be widely held at various platforms beside its bioengineering and designing issues for proper handling and storage concerns. Approval standards and quality control should be a part of the development effort prior to regular production and use of these low cost prostheses.

  • 11 September 2015
    REGULATORY REQUIREMENTS AND REGISTRATION PROCESS OF GENERIC DRUGS IN CHINA

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  • 9 September 2015
    FORMULATION AND EVALUATION OF GASTRORETENTIVE HYDROCHLOROTHIAZIDE FLOATING MICROSPHERES: STATISTICAL ANALYSIS

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  • 7 September 2015
    ANTIBACTERIAL, CYTOTOXIC AND ANTIOXIDANT ACTIVITIES OF N-HEXANE, CHLOROFORM AND ETHYL ACETATE EXTRACTS OF TRICHOSANTHES CUCUMERINA LEAVES

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  • 4 September 2015
    DIAGNOSIS OF GRANULAR CELL TUMOUR OF THE UPPER LIP USING POLYMER HRP DETECTION SYSTEM

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    ABOUT AUTHORS:
    1Neeraj Kumar Lohani*, 2Prakash Singh Nainwal
    1Institute of Biomedical Education & Research, Mangalayatan University, Aligarh- Uttar Pradesh, India,
    2Govt. medical College Haldwani, Nainital Uttrakhand, India
    *neerajlohani06@gmail.com

    ABSTRACT:
    Oral granular cell tumour is a rare soft tissue tumour ofcan develop on any skin or mucosal surface. Granular cell tumors can affect all parts of the body; however, the head and neck areas are affected 45% to 65% of the time. Of the head and neck cases 70% of lesions are located intraorally (tongue, oral mucosa, hard palate). The next most common location that lesions are found in the head and neck area is the larynx(10%).[1] In patients 30% of cases have been reported to occur in the lip, but this presentation in adults is extremely rare. The present study is concerned a case of oral granular cell tumour in a 60 year-old female, located in the upper lip. Histopathological examination revealed granular cells which stained positively for S-100 protein; a finding supportive of a neural origin. A history of trauma was elicited in this case, and the lesion was treated with surgical excision.

  • 2 September 2015
    EVLUATION OF EFFECTS OF COMMIPHORA WIGHTII IN DEHYDROEPIANDROSTERONE (DHEA) INDUCED POLYCYSTIC OVARY SYNDROME (PCOS) IN RATS

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