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  • Evaluating Cassia tora Linn. Seeds for their Antimicrobial Potential with Special Reference to Skin Infections

    About Author: Saurabh Jain.*1, M.D.Kharya and Jain Aakansha2
    1 Department of Pharmaceutical Sciences
    2 Department of Microbiology
    Dr. H. S. Gour Central University Sagar (M.P.), India.470003

    Abstract
    Due to increasing resistance to existing synthetic antimicrobial agents, herbal drugs are being looked as importance source for treating various ailments related to skin infections and also for the discovery of new antimicrobial molecules for their synthesis. Cassia tora is a well known plant possessing wide range of pharmacological activities. It has been used in India as folk remedy in the form of decoctions and infusions to treat bacterial and fungal infections and also claimed to be effective against variety of skin conditions like psoriasis, acne, wounds etc. Although this plant, particularly its seeds have been reported to have antimicrobial activities, but no targeted and specific study has been reported. The present investigation was carried out to study this unexplored area of this drug. As the seeds of C. tora possess good antimicrobial activity, it was thought worked to scientifically explore its potential on microorganisms effecting human beings especially on skin, so that safe and effective herbal treatment can be developed for the same.

  • A Novel Approach for the Treatment of Migraine

    About Author: Shishir Tripathi
    M.Pharm-Pharmaceutics
    Department of Pharmacy,
    Barkatullha University,
    Bhopal-462026, M.P., India

    Abstract
    According to the Migraine Research Foundation, migraine ranks in the top 20 of the world’s most disabling medical illnesses with more than 10 percent of the population, including children, suffering from the migraine. Sumatriptan Succinate is a choice of drug used for the treatment of migraine when received at oral dose its bioavailability is approximately 14%. Considering the low bioavailability after oral and intranasal administration, due to presystemic metabolism and incomplete absorption as well as additional inconveniences associated with parenteral and oral administration, the exploitation of an alternative route of sumatriptan delivery, such as transdermal administration (topical gel)—could be sort out mentioned problem and enhance its therapeutic benefit up to most possible extent. Topical delivery systems of Sumatriptan succinate gel were formulated using polymers like HPMC, Carbopol 934 and Pectin and penetration enhancers like eucalyptus oil, menthol and oleic acid. The gels were evaluated for various parameters such as homogeneity, grittiness, extrudability, in vitro drug release, viscosity, pH, spreadability and drug content. The release rate of the gel was found to obey koresmeyer peppas kinetics. It can be concluded that HPMC gel has properties similar to marketed preparation and eucalyptus oil acts as a good penetration enhancer in Sumatriptan gels as compare to menthol and oleic acid.

  • Memory Enhancing Activity of Methanolic Extract of Selaginella Bryopteris in Swiss Albino Mice

    About Author: Neeraj Kumar Garg*1, Pankaj Khatri1, Sangeeta Gupta2, N. Ganesh2
    1. School of pharmacy, Suresh Gyan Vihar University, Mahal, Jagatpura, Jaipur (Raj.)
    2. Incharge, Department of research, jawahar lal Nehru cancer Hospital and Research centre, Idgah hills Bhopal 462001 (M.P.)

    Abstract
    Alzheimer disease (AD) is a neurodegenerative disorder currently without an effective treatment. Impairment of memory is the initial and most significant symptom of Alzheimer disease (AD). The present study was under taken to investigate the effect of Selaginella bryopteris (popularly known as sanjeevani, Family: Selaginellaceae) on learning and memory. Two doses (250 and 500 mg/kg p.o.) of methanolic extract of Selaginella bryopteris were administered for 7 successive days in separate group of animals. The dose of 500 mg/kg p.o. of the methanolic extract of Selaginella bryopteris significantly improved learning and memory of mice. Antioxidant property of Selaginella bryopteris may be contributing favourably to the memory enhancement effect. However, further studies are necessitated to identify the exact mechanism of action. In the present investigation of Selaginella bryopteris have shown promising memory enhancing agent in the entire laboratory models employed.

  • Biodegradable, Biotechnology and Biopolymers - BBB

    About Author: Ambrish Singh
    B.Pharma, M.Tech (Biotech)
    Anna University,
    Chennai

    Abstract
    Products which degrade upon disposal by the action of living organisms are called 'biodegradable products”. They can be broken down into their constituent natural elements and be absorbed by the environment. There has been a lot of progress in the production of biodegradable products from biopolymers such as starch, cellulose, lactic acid, glycolic acid etc. Biopolymers have a vast range of applications in the production of eco- friendly products such as bioplastics, biopots, biodegradable medical devices, biodegradable implants and drug delivery systems. Using biodegradable products is very important for making the environment “Green”. Advanced techniques in biotechnology have been used to produce genetically modified organisms. These genetically modified organisms are used in the production of biopolymers. Biopolymers help to produce biodegradable products in large quantities at a very low cost. Therefore focusing research in these areas will help to completely avoid the usage of non biodegradable products in future.

  • Modeling and Docking Studies of CASR Involved in Osteoporosis

    About Author: Mr. Naresh. M. Reddy
    PG Diploma (Cheminformatics),
    Nizam College, Osmania University
    Hyderabad.

    Abstract
    Oral strontium ranelate is an alternative oral treatment, belonging to a class of drugs called dual action bone agents. The objective of this investigation was to characterize and determine the effect of the Strontium ranelate on Calcium sensor receptor (CASR) which is an important protein involved Osteophoresis. Homology modeling of CASR has been performed based on the crystal structure of the 2E4U (Chain A) by using Modeller software. With the aid of the molecular mechanics and molecular dynamics methods, the final model is obtained and is further assessed by procheck and verify 3D graph programs, which showed that the final refined model is reliable. With this model, a flexible docking study of CASR with a group of Ranelic acids were selected from the previous publications was performed. The results indicated that VAL1,SER18,SER2,GLU241 in CASR are important determinant residues in binding as they have strong hydrogen bonding with Ranelic acids. These hydrogen binding interactions play an important role for stability of the complex. Among the 15 compunds, 6th showed best docking result. Our results may be helpful for further experimental investigations.

  • Peptic Ulcer Disease and its Screening

    About Author: Ram Ashwin

    Peptic Ulcer Disease and its  screening
    Condition characterized by Erosion of GI mucosa resulting from digestive action of HCl and pepsin or A peptic ulcer is erosion in the lining of the stomach or the first part of the small intestine, an area called the duodenum.
    • Ulcer development
    • Lower esophagus(esophageal ulcer)
    • Stomach(gastric ulcer)
    • Duodenum(duodenal ulcer)

  • Computer Aided Drug Design an Emerging Tool for Research and Drug Development

    About Author: Jadhav Ramulu 1, P. Goverdhan2
    1 Vaagdevi College of Pharmacy, Hanamkonda-Warangal (Affiliated to Kakatiya University), A.P-506002, INDIA
    2 Head of the department, pharmacology, Vaagdevi College of Pharmacy, Hanamkonda-Warangal, A.P-506002, INDIA

    Abstract
    Computer aided drug design(CADD) is an emerging tool for research and drug development process as it reduce the time taken for the process of drug development and expense. Several new technologies have been developed and applied in drug R & D to shorten the research cycle and to reduce the expenses. In computer aided drug design process so many computational tools are used such as over viewing tools, homology modeling, and homology modeling programs, molecular dynamics, molecular docking and QSAR descriptors. This article provides a brief idea on computer aided drug design process and list of software used.

  • A Review on Piperacillin - Tazobactam in Febrile Neutropenia

    About Author: Uday Venkat Mateti1*, Srikala Patha2
    1. Department of Pharmacy Practice  & Pharm.D, St Peter’s Institute of Pharmaceutical Sciences, Rohini Hospital, Kakatiya University, Warangal, India
    2. Department of Pharmacy Practice, Bharat Institute of Technology (Pharmacy), KIMS Hospital, JNTU, Hyderabad, India

    Abstract
    The mortality rate of febrile neutropenia (FN) has diminished steadily but remains significant. Overall mortality rates are 5% in patients with solid tumors (1% in low-risk patients) and as high as 11% in some hematological malignancies. Piperacillin/Tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad spectrum of antibacterial activity against most Gram-positive, Gram-negative aerobic bacteria and anaerobic bacteria. Piperacillin/Tazobactam is effective and well tolerated in patients with febrile neutropenia.  Guidelines for the Management of Febrile Neutropenia in Oncology Patients and the 2010 National Comprehensive Cancer Network (NCCN) Prevention and treatment  for febrile neutropenia recommends as initial treatment in patients with FN who are at high risk of serious infections. In comparative clinical trials against various other antibacterial regimens. Piperacillin/Tazobactam has shown higher clinical success rates, particularly in the treatment of patients with febrile neutropenia. Piperacillin/Tazobactam has shown clinical as well as the economic advantages over other antibacterial regimens in the treatment of febrile episodes in patients with neutropenia. It is likely to reduce overall treatment costs of moderate to severe febrile neutropenia by increasing initial treatment success thereby reducing the length of hospital stay and the use of additional antibacterials. Present data regarding clinical efficacy, safety and costs would support the use of Piperacillin/Tazobactam as an empirical first-line option in moderate to severe febrile episodes in patients with neutropenia.

  • Impact of Mycotoxin in the Program Cell Death / Necrosis

    About Author: Rinki Verma (Research Fellow)
    Center of Experimental Medicine and Surgery,
    Institute of Medical sciences,
    Banaras Hindu University,
    Varanasi, India

    Abstract
    Genetic instability caused by secondary metabolites produced by fungus. These  mycotoxins are chemical compound which are naturally toxic to cells. Because of ability to generating ROS and RNS caused oxidative stress. Due to their toxicity properties implicate apoptosis and form cancer cell. DNA replication are going to impaired and become damage. Mycotoxins are suppressed tumor suppressing gene and convert proto-oncogene in the oncogene. In this review we explain the control exposure of mycotoxins and provides guidelines to farmers because they are directly contact to these compounds.

  • Does Stem Cell Therapy for Diabetic Mellitus

    About Author: Rinki Verma (Research Fellow)
    Center of Experimental Medicine and Surgery,
    Institute of Medical sciences,
    Banaras Hindu University,
    Varanasi-221005, India

    Abstract
    Diabetes mellitus (DM) has reached endemic scope and is an important risk factor for heart failure (HF).Itself indicated as a group of different disease due to destruction of insulin. A large number of therapy available in the management of this but most prominent therapy uses due to their unique properties; stem cell therapy. A stem cell with extensive proliferative nature may provide a precious source of islet progenitor cells. Through transplantation of insulin-producing cells offers a promising therapy to profligate diabetes. A number of studies have demonstrated that a progenitor/stem-cell population can be expanded in vitro to generate large numbers of islet progenitor cells. However, efficient and directed differentiation of these cells to an endocrine pancreatic lineage has been difficult to achieve. They review growing of the islet cells obtained from embryonic stem cell, or adult human tissues which produced insulin to treatments of diabetic patients.

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