A REVIEW ON MIMOSA PUDICA: A USEFUL WEED

 

Ethnopharmacology
The roots and leaves are commonly used in treatment as bitter, astringent, acrid, cooling vulnerary, alexipharmic, diuretic,  antispasmodic, emetic, constipating and febrifuge(13). The leaves and roots are used in the treatment of piles and fistula. Paste of leaves is applied to hydrocele. Cotton impregnated with juice of leaves is used for dressing sinus. Plant is also used in the treatment of sore gum and is used as a blood purifier(3). In Ayurvedic and Unani system of medicine, this plant has been used in diseases arising from corrupted blood and bile, heart disorders, billious fever, piles, jaundice, leprosy, ulcers and small pox. The seeds and other plant parts of sensitive plant contain mimonsine, an amino acid that is known to cause hair loss and depressed growth in mammals(28).

Pharmacology
Ethanolic extract of leaves shows hypoglycemic activity in Alloxan-induced diabetic rats(29).Aqueous extract of Mimosa pudica shows antinociceptive activity(30).Methanolic extract showed significant (p<0.05) hepatoprotective effect by lowering the serum levels of various biochemical parameters such as serum glutamic oxaloacetate transaminase(SGOT), serum glutamic pyruvates transaminase (SGPT), alkaline phospatase (ALP), total bilirubin (TBL), total cholesterol (CHL) and by increasing the levels of total protein (TPTN) and albumin (ALB), in the selected model(31).Aqueous extract of dried roots of Mimosa pudica was tested for inhibitory activity on lethality, phospholipase activity, edema forming activity, fibrinolytic activity and hemorrhagic activity of Najanaja and Bangaruscaerulus venoms(32).Ethanolic extracts of Mimosa pudica leaves shows antimicrobial activity of the plant materials is due to the presence of active constituents like alkaloids or tannins(15).Mimosa pudica root methanolic extract showed very good wound healing activity when compared to the standard drug Gentamicin (33).The decoction ofMimosa pudica leaves shows anticonvulsant activity(34).The aqueous extract of Mimosa pudica is showed anti-asthmatic activity in in-vitro and in vivo animal models(35).Ethanol extract of Mimosa pudica exhibited a significant hypolipidemic activity(36).Alcoholic extract of Mimosa pudica significantly (P < 0.001) decreases the volume of gastric acid secretion, PH, free acidity, total acidity and ulcer index with respect to control(37).Ethanolic extract of roots of mimosa pudica Linn produced a significant and sustained increase in the aphrodisiac activity of normal male mice, without any diverse effects(38).

CONCLUSION
Despite the wide use of chuemue, its chemotherapeutic value has not been fully substantiated and the mode of action of its bioactive compounds against diseases has no yet been established. Alkaloids, flavonoids, tannins, steroids and glycosides which were isolated from this plant may be responsible for its pharmacological activities. The road ahead is to establish specific bioactive molecules, which might be responsible for these actions. Therefore the cultivation, collection, and further pharmacological exploration ofMimosa pudica are essential.

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