A REVIEW ON: FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET

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Table 1.2: Comparison of Fast-Dissolving/Disintegrating Technologies

ZYDIS (R.P. SCHERER, INC.)

Novelty

Handling/Storage

Drug Release/Bioavailability

First to market

Do not push tablet through foil

Dissolves in 2 to 10 seconds

Freeze Dried

Do not use dosage form from damaged package

May allow for pre-gastric absorption leading to enhanced bioavailability

 

Sensitive to degradation at humidities >65%

 

ORASOLV (CIMA LABS, INC.)

Novelty

Handling/Storage

Drug Release/Bioavailability

Unique taste masking

Packaged in patented foil packs

Disintegrates in 5 to 45 seconds depending upon the size of the tablet

Lightly compressed

 

No significant change in drug bioavailability

DURASOLV (CIMA LABS, INC.)

Novelty

Handling/Storage

Drug Release/Bioavailability

Similar to Orasolv, but with better mechanical strength

Packaged in foil or bottles

Disintegrates in 5 to 45 seconds depending upon the size of the tablet

 

If packaged in bottles, avoid exposure to moisture or humidity

No significant change in drug bioavailability

WOWTAB (YAMANOUCHI PHARMA TECHNOLOGIES, INC.)

Novelty

Handling/Storage

Drug Release/Bioavailability

Compressed dosage form

Package in bottles

Disintegrates in 5 to 45 seconds depending upon the size of the tablet

Compressed dosage form

Package in bottles

Disintegrates in 5 to 45 seconds depending upon the size of the tablet

Proprietary taste masking

Avoid exposure to moisture or humidity

No significant change in drug bioavailability

Table1.3: Some Patented Technologies for Fast Dissolving Tablets

Technology

Company's Name

Technology Base

Durasolv, Orasolv 

CIMA Labs Inc.  

Molding 

Flash Tab 

Ethypharm 

Molding 

Wow Tab 

Yamanouchi pharma 

Molding 

Zydis 

R. P. Scherer, Inc. 

Freeze dried Wafers 

Flash Dose 

Fuisz Technology, Ltd.

Cotton –candy Process 

Ziplets 

Eurand 

Molding 

Fast Melt 

Elan Corp. 

Molding 

Conclusion:
Besides delivering drug to the body, a drug delivery system aim to improve patient compliance and convenience, and fast dissolving tablets are no exception. The introduction of fast dissolving dosage forms has solved some of the problems encountered in administration of drugs to the pediatric and elderly patient, which constitutes a large proportion of the world's population. Hence, patient demand and the availability of various technologies have increased the market share of Fast dissolving tablets, which in turn prolongs the patent life of a drug.Recent trends of patient oriented practice demand design of patient oriented dosage form to achieve patient compliance. The number of formulation related factors contributes to the significant amount of non-compliance and hence there is a need to design patient oriented drug delivery system.  Mouth dissolving tablets are ideal for many groups of patients including geriatrics, pediatrics, psychiatrics and for those people who have difficulty in swallowing. By using such manufacturing technologies, many drugs can be formulated in the form of mouth dissolving tablets to provide the advantages of liquid medication in the form of solid preparation.  Keeping in view of the advantages of the delivery system, rapidly disintegrating dosage forms have been successfully commercialized, and because of increased patient demand, these dosage forms are expected to become more popular.

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