Pharma Admission

Pharma courses

pharma admission

pharma courses

This technique was successfully applied for low dose water insoluble drugs. When the therapeutic dose of drug is more than 50mg, dissolution enhancement in the presence of low levels of hydrophilic carrier and coating material is not significant. But by adding some materials such as polyvinyl pyrrolidone (PVP) to liquid medication (microsystems), it would be possible to produce dry powder formulations containing liquid with high concentration of drug. By adding such materials to the liquid medication, low amount of carrier is required to obtain dry powder with free flowability and good compatibility (Amrit et al., 2009).

In the liquisolid and powdered solution systems the drug might be in a solid dosage form, it is held within the powder substrate in solution, or in a solubilized, almost molecularly dispersed state. Therefore, due to their significantly increased wetting properties and surface of drug available for dissolution, liquisolid compacts of water insoluble substances may be expected to display enhanced drug release properties, and consequently, Improved bioavailability (Yadav VB and Yadav AV., 2009).

The Liquisolid system is a technique for formulation of water insoluble drugs to enhance their aqueous solubility, absorption as well as dissolution rate which leading to enhancement of bioavailability of drugs as compared to conventional directly compressed tablets. Orodispersible tablets may give rapid onset of action by rapid absorption through pre-gastric absorption of drug from mouth, pharynx and oesophagus as saliva passes down and beneficial to reduce dose. By combining Liquisolid technique and Orodispersible DDS, may enhance solubility, dissolution rate by means of Liquisolid technique and can achieve rapid onset of action with lower dose of drug by using Orodispersible DDS and hence may increase patient compliance.

1. Abdul Hasan Sathali A., Deepa C (2013); Formulation of liquisolid tablets of candesartan cilexetil; Int. J. Res. Pharm. Sci; 2013; 4(2); 238-249.
2. Amrit B., Karmarkar Indrajeet D.,Gonjari.,  Avinash H Hosmani., Pandurang N Dhabale.,  Satish B Bhise (2009); Liquisolid Tablets: A Novel Approach for Drug Delivery; International Journal of Health Research; 2009; 2(1); 45-50.
3. Bhise SB., Nighute AB., Yadav AV., Yadav VB (2009); Aceclofenac size enlargement by non aqueous granulation with improved solubility and dissolution; Arch Pharm Sci & Res; 2009; (1); 115-122.
4 .Chang RK., Guo X., Burnside BA., Cough RA (2002); Fast dissolving tablets; Pharm Tech; 2002; (24); 52-58.
5. Dokoumetzidis A., & Macheras P (2006); A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system; International journal of pharmaceutics; 2006; (321); 1 –11.
6. Gubbi S.R., Jarag  R (2009); Research J. Pharm. And Tech; 2009; 2(2); 382-386.
7.  Hamsanandini J., Parthiban S., Vikneswari A., Sentil kumar G.P., Tamiz Mani T (2015); Formulation and Evaluation of Orodispersible Liquisolid Compacts of Meloxicam using Banana Powder as a Natural Superdisintegrants; Asian Journal of Research in Biological and Pharmaceutical Sciences; 2015; 3(1);  25-38.
8. Javadzadeh Y., Nokhodchi A (2008); Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine); Int J Pharm; 2008; 341;26-34.
9. Kaushik D., Dureja H., Saini TR (2004); Mouth dissolving tablets: A Review; Indian Drugs; 2004; 41(4): 187-193.
10. Kumar S., Gupta SK., Sharma PK (2012); A Review on Recent Trends in Oral Drug Delivery-Fast Dissolving Formulation Technology; Adv Biol Res; 2012; (6); 6-13.
11. Mudgal V.K., singhai A.K (2011); Orally Disintegrating tablet: A Review; International Research Journal of pharmacy; 2011; ISSN 2230-8407.
12. Munke AP., Nagarsenker MS (2004); Triamterene β-cyclodextrin complexes: Preparation, characterization and In vivo evaluation; AAPS PharmSciTech; 2004; (5); 1-9.
13. Nazzal S., Khan MA (2006); Controlled release of a self-emulsifying formulation from a tablet dosage form: Stability assessment and optimization of some processing parameters; Int. J. Pharm; 2006; (315); 110–121.
14. Reddy M., Babu S., Harshita B., Sravya R (2012); Conventional and Patented Technologies in Oral Dispersible Tablets: A Review; J Chem Pharm Sci; 2012; (6); 286-92.
15. Saharan V (2009); Dissolution enhancement of drugs. Part I: technologies and effect of carriers; Int. J. Health Res; 2009; (2); 107-24.
16. Sambasiva AR., Naga TA (2011); Liquisolid Technology: An Overview; Int J Res Pharma Biomed Sci; 2011; 2(2); 401-409.
17. Shashidher B., Veera R (2012); Formulation and evaluation of carvedilol liquisolid tablets; A. j. p. s. P; 2012; 30-44.
18. Shu T (2002); Studies of rapidly disintegrating tablets in oral cavity using co-ground mixture of mannitol with crospovidone; Chem Pharm Bull; 2002; (50); 193-198.
19. Spireas S (2002); Liquisolid Systems and Methods of Preparing Same; U.S. Patent 6423339 B1; 2002.
20. Spireas S., Bolton M (1999); Liquisolid Systems and Methods of Preparing Same; U.S. Patent 5968.1999; 550.
21. Spireas S., Sadu S (1998); Enhancement of prednisolone dissolution properties using liquisolid compacts; Int. J.Pharm; 1998; (166):177–188.
22. Tayel SA., Soliman II., Louis D (2008); Improvement of Dissolution Properties of Carbamazepine through Application of the Liquisolid Technique; Eur J Pharm Biopharm; 2008; (69); 342-347
23. Velmurugan S., Vinushitha S (2010); Oral Disintegrating Tablets: An Overview; Int J Chem Pharm Sci; 2010; 1-12.
24. Vijaykumar Nagabandi., Ramarao T., Jayaveera K.N (2011); Liquisolid Compacts: A Novel Approach to Enhance Bioavailability of Poorly Soluble Drugs; International Journal of Pharmacy and Biological Sciences; 2011; 89-102.
25. Yadav A.V., Shete A.S., Dabke A.P (2010); Indian J. Pharm. Educ. Res; 2010; 44(3); 227-235
26. Yadav VB., Yadav AV (2009); Liquisolid granulation technique for tablet manufacturing: an overview; Journal of Pharmacy Research; 2009; 2(4); 670-674.


SUBMIT YOUR ARTICLE/PROJECT AT editor-in-chief@pharmatutor.org

Subscribe to Pharmatutor Alerts by Email