ORODISPERSIBLE LIQUISOLID COMPACTS: A NOVEL APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY
SOLUBILITY AND DISSOLUTION IMPROVEMENT:
This technique was successfully applied for low dose water insoluble drugs. When the therapeutic dose of drug is more than 50mg, dissolution enhancement in the presence of low levels of hydrophilic carrier and coating material is not significant. But by adding some materials such as polyvinyl pyrrolidone (PVP) to liquid medication (microsystems), it would be possible to produce dry powder formulations containing liquid with high concentration of drug. By adding such materials to the liquid medication, low amount of carrier is required to obtain dry powder with free flowability and good compatibility (Amrit et al., 2009).
In the liquisolid and powdered solution systems the drug might be in a solid dosage form, it is held within the powder substrate in solution, or in a solubilized, almost molecularly dispersed state. Therefore, due to their significantly increased wetting properties and surface of drug available for dissolution, liquisolid compacts of water insoluble substances may be expected to display enhanced drug release properties, and consequently, Improved bioavailability (Yadav VB and Yadav AV., 2009).
The Liquisolid system is a technique for formulation of water insoluble drugs to enhance their aqueous solubility, absorption as well as dissolution rate which leading to enhancement of bioavailability of drugs as compared to conventional directly compressed tablets. Orodispersible tablets may give rapid onset of action by rapid absorption through pre-gastric absorption of drug from mouth, pharynx and oesophagus as saliva passes down and beneficial to reduce dose. By combining Liquisolid technique and Orodispersible DDS, may enhance solubility, dissolution rate by means of Liquisolid technique and can achieve rapid onset of action with lower dose of drug by using Orodispersible DDS and hence may increase patient compliance.
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