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  • A CURRENT REVIEW ON ANTIVIRAL DRUGS

    About Authors:
    Mayure.Vijay Kumar*1, Mayure.Ashok2, Athiya Mohammadi1,  C.P.Meher1
    Department of pharmaceutical chemistry
    1Maheshwara College of Pharmacy, Chitkul (V), Isnapur “X” Road, Patancheru, Hyderabad,
    2Gokaraju Rangaraju College of pharmacy, Hyderabad.

  • REVIEW ON ASYMMETERIC CATALYTIC HYDROGENATION

    About Author:
    Sarabjeet Kaur
    M.pharm Lord Shiva College of pharmacy Sirsa
    Teaching Assistant Dept of Pharm. Edu. and research, Bhainswal Kalan
    BPSMV, Sonipat
    jassarab@gmail.com

  • A REVIEW ON SUBSTITUTED BENZOTHIAZOLES

    About Authors:
    Swathi.Pathi*, Swarna Latha.D, M.Sreenivasulu.
    Department of Pharmaceutical Chemistry,
    Annamcharya college of pharmacy, newboyana pally, rajampet(M),
    kadapa(dt). Andhara Pradesh, India.
    *swathi.janu3@gmail.com

  • Automated analysis

    About Authors:
    Patelia emanual michael*, Keyur B Ahir
    Department of Pharmaceutical Chemistry and Analysis,
    Indukaka Ipcowala College of Pharmacy,
    New Vallabh Vidyanagar – 388121, Gujarat, India.
    *ricky.emanual@gmail.com

  • SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME CALCIUM CHANNEL BLOCKER THIOSALICYLAMIDE DERIVATIVES AS ANTIHYPERTENSIVE AGENTS

    About Author:
    ABHISHAK SINGH PARMAR,
    M.PHARMACY (MEDICINAL AND PHARMACEUTICAL CHEMISTRY),
    B.R.NAHATA COLLEGE OF PHARMACY,
    MANDSAUR (M.P).
    *abhishakparmar@gmail.com

    1. INTRODUCTION
    1.1 Medicinal and Pharmaceutical chemistry

    It is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Compounds used as medicines are overwhelmingly organic compounds including small organic molecules and biopolymers. However, inorganic compounds and metal-containing compounds have been found to be useful as drugs. For example, the cis-platin series of platinum-containing complexes have found use as anti-cancer agents.1

  • SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL THIAZOLO[3,2-a]PYRIMIDINES

    About Authors:
    Shaishavi Parikh*, Arun Parikh, Vijayalakshmi Gudaparthy
    Department of pharmaceutical chemistry, L. J. Institute of Pharmacy,
    Ahmedabad-382210, India.
    *shaishavi21@rediffmail.com

    Abstract
    Thiazolo[3,2-a]pyrimidine were synthesized by the reaction of the indole aldehyde with thiourea and methyl isobuterylacetate to generate thioxo pyrimidine compound which condensed to phenacyl bromide to form thiazolo[3,2-a]pyrimidine. All synthesized compounds are characterized by the IR, Mass and NMR spectroscopy and evaluated for the antibacterial and anti fungal activity by using B. cereus, S. aureus strains of Gram positiveE. coli strain of Gram negative andC.albicans strain of fungus. The compound having nitro and methoxy substituent shows significant activity in thiazolo[3,2-a]pyrimidine derivatives.

  • A MAJOR APPROACH- 2-CHLOROPYRIDINE-5-TRIFLUOROMETHYL DERIVATIVE AS ANTIAMNESIC AGENTS

    About Author:
    Ravindra Singh Tomar
    M.Pharm (Medicinal & Pharmaceutical Chemistry),
    B R Nahta College of Pharmacy, Mandsaur (M.P)
    ravindratomar16@gmail.com

    ABSTRACT-
    Here a scheme has been designed for synthesis of 2-chloropyridine-5-trifluoromethyl derivatives. The probability of being antiamnesic agent has been checked by pass prediction. All compound shows antiamnesic activity as result of pass prediction. By Lipinski rule of five all compounds shows drug like activity. Also a method for pharmacological evaluation & Biochemical evaluation is described under. All synthetic procedure has been designed & described under-

  • SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 3-(2-(1H-INDOL-2-YL) PHENYL)-2-ARYLIMIDAZO[4,5-b]INDOLES

    About Authors:
    Aditya Dixit1, Gyanendra Kumar Sharma2, Devender Pathak*3
    1M. Pharmacy (Pharmaceutical Chemistry)
    2Associate Professor (Pharmaceutical chemistry)
    3Director, Professor and Head of the Dept. (Pharmaceutical Chemistry)
    Rajiv Academy for Pharmacy, Mathura,
    Delhi-Mathura Highway, Chhattikara, 281006, India
    dev_15@rediffmail.com*, adixit70@gmail.com

    ABSTRACT
    A traditional but effective method of developing new targets is lead molecule modification, where an existing popular drug from the market is taken as a lead and similar derivatives are synthesized. With the advent of modern techniques conventional methods have lost their gleam but, reactions are still best understood when performed by the conventional techniques. One such endeavor has been made here where indole has been used as a parent moiety and by adding some functional groups some novel indole derivatives were synthesized and screened for their in vitro antitubercular, and anticancer activity. This synthesis of some fresh indole derivatives was done by using various benzaldehyde derivatives and 2-(o-Aminophenyl)indole in acidic condition then with ammonium acetate and isatin in presence of glacial acetic acid.. The structures of newly synthesized compounds were characterized by IR, 1H NMR, MASS and elemental analysis.Compounds 3h & 3i showed good antitubercular activity and 3d, 3e & 3g showed good anticancer compared to the standard drug.

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  • FOOD CONTAMINANTS: BANGLADESH PERSPECTIVE

    About Authors:
    Zubair Khalid Labu1; AK Mohiuddin1; M.A Bake*2
    1Department of Pharmacy, World University of Bangladesh (WUB), Dhaka-1215, Bangladesh
    *2Product Development officer, Gonoshasthaya Pharmaceuticals Ltd., Mirzanagar, Savar, Dhaka-1344.
    zubairlabu@yahoo.com; *abdul.bake@yahoo.com

    Abstract
    Food is the major source of energy in humans as well as animals. Foods are materials taken into the body by different route which provide nourishment in the form of energy or in the building of tissues. Food contaminants are substances that make food unfit for human consumption. Examples include bacteria, toxic chemicals, carcinogens, teratogens and radioactive materials. The purpose of these studies is to find out the food contaminants which are used in different purposes available in Bangladesh and contaminants detection method. After survey we found that Dhaka is the main city where food contamination by various contaminants in higher percentage. This contamination done by manmade, industrial discharge, poisonous water etc. Government of Bangladesh taking various necessary steps to stop this contamination.

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  • REVIEW OF A REAL VERSATILE MOLECULE

    About Authors:
    C.P.Meher
    Asst. Professor
    Maheshwara Institute of  Pharmacy,
    Chitkul, Patancheru, Medak, A.P
    chaitanyameher84@gmail.com

    ABSTRACT
    Pyrazole, a 5-membered heterocyclic diazole alkaloid composed of three carbon atoms and two nitrogen atoms in adjacent positions, is a prevalent scaffold in drug discovery programs. The aim of this review is to provide an overview of diverse pharmacological activities of pyrazole moiety.This review highlighted recent reports of antimicrobial, anticancer, ACE inhibitory, antiviral as well as anti-inflammatory activities of pyrazole. The purpose of this review was to collate literature work reported by researchers on pyrazole for their varoius pharmacological activities and also reported recent efforts made on this moiety.

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