A REVIEW ON HERBAL NANOPARTICLES
Paclitaxel: Paclitaxel is a major anticancer drug isolated from the bark of Taxus brevifolia Nutt. (Family- Taxaceae). But its high lattice energy results in very limited aqueous solubility (0.7- 30 ug/ml-1) limited its efficacy (Spencer et al., 1994). Thus incorporation of paclitaxel into nanoparticles enhanced its anti- tumoral activity (Breuning et al., 2008). Paclitaxel loaded nanoparticles were prepared by nanoprecipitation method (Fessi et al., 1989) and by sequential simplex optimization method (Dong et al., 2009). Paclitaxel nanoparticles enhance drug stability, support sustained drug release and improve bioavailability.
Quercetin: Quercetin is a flavonoid excreted from air dried plant part of Spohora japonica L. (Family- Fabaceae) mainly from bark and leaf. The antioxidant activity of Quercetin is higher than well known antioxidants like ascorbyl, trolox (Nuengchamanong et al., 2004). Apart from the antioxidant activity, it shows anticancer and antiviral activities (Formica et al., 1995; Schaab et al., 2006; Zheng et al., 2005). Inspite of this wide spectrum of pharmacological properties, its use in pharmaceutical field is limited due to its low aqueous solubility and instability in physiological medium results in poor bioavailability (Prasad et al., 2004). The nano-encapsulation of Quercetin into PLA (poly-D, L-lactide) nanoparticles significantly improves the therapeutic efficacy and bioavailability. Quercetin loaded PLA (poly-D, L-lactide) nanoparticles have been prepared by solvent evaporation method (Kumar et al., 2010) and by using bovine serum albumin (Fang et al., 2011).
At present, herbal medicines have been getting more attention because of their potential to treat almost all diseases. However, several problems (poor solubility, poor bioavailability, low oral absorption, instability and unpredictable toxicity) associated with herbal medicines limit their use. In order to overcome such problems, “Nanotechnology” has established the attractive therapies to the pharmaceutical that will encounter the problem associated with herbal medicines. It is anticipated that the effectual and valuable relevance of the natural products and herbal remedies being applied with the nanocarrier will enhance the significance of existing drug delivery systems.
1. Anand P, Kunnumakkara AB, Newman RA. Bioavailability of Curcumin: Problems and Promises, Mol Pharmaceutics, 2007; 4 (6):807-818.
2. Ansari SH, Farrha I, Sameem M: Influence of nanotechnology on herbal drugs: A Review. Journal of advanced pharmaceutical technology and research 2012; 3(3): 142.
3. Bao X, Wang Z, Fang J and Li X, Structured features of an immunostimulating and antioxidant acidic polysaccharide from the seeds of Cuscutta chinensis, Planta Med, 2002, 8, 237-243.
4. Bisht S, Feldmann G, Soni S, Ravi R, Karikar C and Maitra A, Polymeric nanoparticles-encapsulated curcumin (nanocurcumin): a novel strategy for human cancer therapy, J Nanobiotechnol, 2007, 5(3), 2-18.
5. Bradwejn JT, A double blind, placebo controlled study on the effects of Gotu Kola- (C. asiatica) on acoustic startle response in healthy subjects, J Clinic Pharmacol, 2000, 20, 680-84.
6. Breuning M, Bauer S and Goepferich A, Polymers and Nanoparticles: intelligent tools for intracellular targeting, Eur J Pharm Biopharm, 2008, 68, 112-128.
7. Cassidy A, Albertazzi P and Lisc Nielsen I, Critical review of health effects of soyabean phyto-estrogen in post-menopausal women, Proc Nutr Soc, 2006, 65, 76-92.
8. Chen Y, Lin X, Park H and Greever R, Study of artemisinin nanocapsules as anticancer drug delivery systems, Nanomedicine: Nanotechnol, Biol Med, 2009,3, 316-322.
9. Chidambaram M, Manavalan R, Kathiresan K: Nanotherapeutics to overcome conventional cancer chemotherapy limitations. Journal of pharmacy and pharmaceutical sciences 2012; 14: 67–77.
10. Dong X, Mattingly CA, Tseng M, Cho M, Adams VR and Mumper RJ, Development of new lipid based paclitaxel nanoparticles using sequential simplex optimization, Eur J Pharm Biopharm, 2009, 72(1), 9-17.
11. Elzoghby A, Samy W, Elgindy N: Protein-based nanocarriers as promising drug and gene delivery systems. Journal of controlled release 2012; 161(1):38-49.
12. Fang R, Hao R, Wu X, Li Q, Leng X and Jing H, Bovine serum albumin nanoparticles promotes the stability of quercetin in simulated intestinal fluid, J Agri Food Chem, 2011, 59, 6292-6298.
13. Fessi H, Puisieux F, Devissaguet JP, Ammoury N and Benita S, Nano-capsule formation by interfacial polymer deposition following solvent displacement, Int J Pharm, 1989, 55, 1-4.
14. Formica JV, Regelson W, Review of the biology of quercetin and related bioflavonoids, Food Chem Toxicol, 1995, 33, 1061-1080.
15. Fukuda K, Hibiya Y and Mutoh M, Koshiji M, Akao S and Fujiwara H, Inhibition of activation protein 1 activity by berberine in human hepatoma cells, Planta Med,1999, 65, 381-383.
16. Gleave M, Bruchovsky N, Goldenberg SL and Rennie P, Intermittent androgen suppression for prostate cancer: rationale and clinical experience, Eur Urol, 1998, 34, 37-41.
17. Goyal A, Kumar S, Nagpal M, Singh I, Arora S. Potential of novel drug delivery system for herbal system for herbal drugs. Indian journal of pharmaceutical education and research. 2011; 45:225-235.
18. Gupta VK, Karar PK, Ramesh S, Misra SP, Gupta A: Nanoparticle formulation for hydrophilic and hydrophobic drugs. International journal of research in pharmaceutical sciences 2010; 1:163-69.
19. Hua-Yan, Li, Dng-Peng, Wang, Tian-Ming, Zhang, Hao-Li, Ren, Fang-Yuan, Xu, Zhu-Guo and Zhao, J Nanosci Nanotechnology, 2010, 10(4), 2325-2331.
20. Kang DG, Oh H, Sohn EJ, Hur TY, Lee KC, Kim KJ, Kim TY and Lee HS, Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/ reperfusion-induced renal injury in rats, Life Sci, 2004, 75, 1801-1816.
21. Kiuchi F, Goto Y, Sugimoto N, Akao N, Kondo K, Tsuda Y. Nematocidal activity of turmeric: synergistic action of curcuminoids. Chem Pharm Bull (Tokyo) 1993;41:1640.
22. Kumar A, Yadev SK, Pakade YB, Singh B and Yadev SC, Development of biodegradable nanoparticles for delivery of quercetin, Colloids and Surface B, Biointerfaces, 2010, 15, 184-192.
23. Kumar K, Rai AK. Miraculous therapeutic effects of herbal drugs using novel drug delivery systems. International Research Journal of Pharmacy. 2012; 3:2733.
24. Kumar M H V, Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats, J Ethnopharmacol, 2002, 79, 253-60.
25. Kolammal M. Pharmacognosy of Ayurvedic Drugs, series-1. Trivandrum: Ayurveda Research Institute, 1978: p.1.
26. Lamartinicr CA, Murill WB and Manzolillo PA, Genistein alters the ontogeny of mammary cancer in rat, Pro Soc Exp Biol Med, 1998, 217, 358-364.
27. Liu JR, Chen GF, Shih HN and Kuo PC, Enhanced antioxidant bioactivity of Salvia miltiorrhiza (Danshen) products prepared using nanotechnology, Phytomedicine, 2008, 15, 23-30.
28. Liu JH, Jiang B, Bao YM and An LJ, Effect of Cuscutta chinensis glycoside on the neuronal differentiation of rat pheochromocytoma PC12 cells, Intern J Developm Neurosc, 2003, 21, 277-281.
29. Lucia RD, Pharmacological and toxicological studies on Centella asiatica, Fitoterapia, 1997,68,413-16.
30. Moom A, Jonas A, Losic D: A multi-drug delivery system with sequential release using titania nanotube arrays. Chemical communications 2012; 48:3348-50.
31. Nisha M, Akbar S, Tariq M and Hussain Z, Effect of Cuscutta chinensis water extract on 7, 12-dimethylbenz a anthracene- induced skin papillomas and carcinomas in mice, J Ethnapharmacol, 1986, 18, 21-31.
32. Nuengchamanong N, Lokkerbol HA and Ingkaninan K, Separation and detection of the antioxidant flavonoids, rutin and quercetin, using HPLC coupled on-line with colorimetric detection of antioxidant activity, Naresuan Univ J, 2004, 12, 25-37.
32. Okonogai S, Sirithunyalang J and Chen U, Nanoencapsulation of Centella asiatica bioactive extract, In: XVIth International Conference on Bioencapsulation, Dublin, Ireland, 2008, Sep 4-6, p.1-4.
34. Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R and Langer R, Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2007, 2, 751-760.
35. Peng Q, Tao G, Jiao Z, Jie L, Dong Z and Zhirong Z, Enhanced the oral bioavailability of savianolic acid B by phospholipid complex loaded nanoparticles, Die Pharmazie(IJPS), 2008, 63, 661-666.
36. Prasad T and Rajendra kumar K, Study of freeze dried quercetin- cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis, J Pharm Biomed Anal, 2004, 34, 333-339.
37. Reichard P, Nielsen OS, Bauer S, Hartmann JT, Schoffski P, Christensen TB, Exatecan in pretreated adult patients with advanced soft tissue sarcoma: result of a phase-II. A study of EORTC soft tissue and bone sarcoma group, Euro J Cnacer, 2007,43,1017-1022.
38. Roy AM, Baliga MS, Elmets CA and Katiyar SK, Grape seed proanthocyanidins induce apoptosisthrough p53, Bax, and caspase-3 pathways, Neoplasia, 2005,7,24-36.
39. Rusin A, Krawezyk Z, Grynkiewicz G, Gogler A, Zawisza-Puchalka J of genistein, their properties and possible application, Acta Biochim Pol, 2010, 57, 23-34.
40. Sathyavathi G V, Gupta AK and Tandon N, Medicinal Plants of India, Vol. 2, New Delhi(India), Indian Council OF Medical Research, 1987, 230-239.
41. Schaab MR, Barney BM and Francise WA, Kinetiv and spectroscopic studies on the quercetin 2,3-dioxygenase from Bacillus subtilis, Biochemistry, 2006, 45, 1009-1016.
42. Sharma AT, Mitkare SS, Moon RS. Multicomponent Pharmaceutical Science Review and Research. 2011; 6:185-187.
43. Sharma K, Agrawal SS, Gupta M. Development and validation of uv spectrophotometric method for the estimation of curcumin in bulk drug and pharmaceutical dosage forms. Int J drug dev res, 2012; 4(2): 375-380.
44. Sharma M: Applications of Nanotechnology Based Dosage Forms for Delivery of Herbal Drugs. Research and Reviews: Journal of pharmaceutics and nanotechnology 2014; 2(1).
45. Singh RP, Singh SG, Naik H, and Jain D, Bisla S: Herbal excipients in novel drug delivery system. International journal of comprehensive pharmacy 2011; 2:1-7.
46. Spencer CM and Faulds D, Paclitaxel- a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer, Drugs, 1994, 48, 794-847.
47. Tang J, Xu N, Ji H, Liu H, Wang Z and Wu L, Eudragit Nanoparticles containing genistein: formulation, development and bioavailability assessment, Int J Nanomed, 2011, 6, 2429-2435.
48. Thakur L, Ghodasra U, Patel N, Dabhi M. Novel approaches for stability improvement in natural medicines. Pharmacognosy Reviews. 2011; 5:48-54.
49. Umehara K, Nemoto K, Ohkubo T, Miyase T, Degaw M and Noguchi H, Isolation of a new 15-membered macrocyclic glycolipid lactone, Cuscutic Resinoside from the seeds of Cuscutta chinensis; a stimulator of breast cancer cell proliferation, Planta Med, 2004, 70, 299-304.
50. Usui T, Pharmaceutical prospects of phytoestrogens, Endocr J, 2006, 53, 7-20.
51. Van Wyk B E, Medicinal Plants of South Africa, Briza Publications, Pretoria, 1997, 78-79.
52. Yadev D, Suri S, Choudhary AA, Sikender M, Heman, Beg MN et al. Novel approach, herbal remedies and natural products in pharmaceutical science as nano drug delivery systems. International Journal of Pharm Tech Research. 2011; 3(3):3092-3116.
53. Yen FL, Wu TH, Lin L, Cham TM and Lin CC, Nanoparticles formulation of Cuscutta chinensis prevents acetaminophen-induced hepatotoxicity in rats, Food Chem Toxicol, 2008, 46,1771-1777.
54. Zheng Y, Hasworth IS, Zuo Z, Chow MS and Chow AH, Physicochemical and structural characterization of quercetin- beta-cyclodextrin complexes, J Pharm Sci, 2005, 94, 1079-1089.
55. Zhou L, Chow M and Zhou Z, Improved quality control method for Danshen products – consideration of both hydrophilic and lipophilic active componenets, J Pharm Biomed Anal, 2006, 41, 744-750.
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