November 2011

ANSWERS of Previous PharmaQUIZ-19:

1.C    2.B    3.D    4.B    5.B

6.A    7.B    8.C    9.B    10.A

About Author:
E.Ashwini
Microbiologist  In  Institute Of Health Systems, Hyderabad
M.Sc Microbiology From Osmania University.

ABSTRACT
The purpose of this study was to determine the effect of some cultural conditions on the xylanase enzyme production by two Isolated Species from the industrial soiland to investigate its potential to produce xylanase utilizing tomato pomace as a substrate. Xylanase activity was detected using the Dinitrosalicylic acid assay method.
The Alkalophilic bacteria isolated from the industrial soil, secreats extra cellular xylanases when grown in liquid media supplemented with eithter rice bran, grass, corn cob, or sugar baggage as a carbon sources (which were treated with 2N NaoH for removing the cellulose from these substrates). The two bacteria belonging to the species Sporo lactobacilli and Acrobacter respectively shows the high enzyme activity at high temperatures 50 degree C and 60 degree C and high enzyme activity was found at pH 8 and pH 9 for two organisms. The extra cellular enzyme has an apparent molecular weight of 66 KD & 67KD for both the organism respectively, as determined by SDS-PAGE. The purified enzyme has two peptides and was conformed by Zymogram analysis. The species sporo lactobacilli show high enzyme activity of 4.7 U/ml and the species Acrobacter shows the enzyme activity of 7.46 U/ml.

About Authors:
Dr. Amit Gangwal,
Smriti College of Pharmaceutical Education,
Indore

Introduction
Lipitor® is the best-selling drug ever, accounting for $106 billion sales over the last decade. Two generic drug manufacturers are ready to compete starting December 1, 2011. Watson Pharmaceuticals is making a generic version authorized by Pfizer under a profit-sharing agreement. Pending federal approval, Ranbaxy Laboratories also plans to sell a generic version. It is noteworthy that when a drug’s patent protection expires, the federal law permits only limited generic competition in the first six months¹.

ANSWERS of Previous PharmaQUIZ-18:

1.B    2.D    3.C    4.D    5.D

6.B    7.C    8.D    9.A    10.A

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