Articles

15 October 2012

HIV / AIDS EVOLUTION AND CONSIDERATIONS

About Authors:
Nishant kumar singh
Research Fellow,
ICRI (Ahm) and Cranfield University
* nishantsingh.shree@gmail.com

ABSTRACT:
Over 3 decades HIV/AIDS have been a major globally accepted challenge, from endemic to a catastrophic pandemic & explodes globally. Estimates says 33.3 million HIV ^+veand 2.6 million newly HIV infected people are in 2009. Since the beginning of epidemic, nearly 30 million people have died from AIDS related cause^[1]. From chimpanzees to human^[2] and then human to human (migration^[3], MSM, HS, IDU, MTC etc) and ultimately it transformed into pandemic. After 30 years we have advanced our treatment & Medicare knowledge of HIV and AIDS. Our scientist has developed several successful targets and drugs based on them, a highly effective therapy HAART currently in use (managing viral load & cell count for better patient survival rate) showing good results. Still HIV/AIDS is incurable, WHY? It shows the need of critical thinking from the very 1^st initial step i.e. TARGET. HIV itself is the target; biotech and Pharmaceutical Company must consider nanotechnology & homologous approach for CCR5. Though it seems that we have control over it but if this goes out same way, than one day just due to the HIV typical characteristic of mutation and recombination the worst Catastrophic sub Saharan-Africa epidemic will become Pandemic.[i]
14 October 2012

Enzyme Linked Immuno Sorbent Assay- An overview

About Authors:
Krunal Parikh^*, Mr. Maheshkumar Kataria, Jatin Patel, Tarun Patel, Dhiren Shah
Seth G. L. Bihani S.D. College of Technical Education, Institute of Pharmaceutical Sciences and Drug Research,
Sriganganagar, India
*Krunal_2922@yahoo.in

ABSTRACT
Enzyme-linked immunosorbent assays (ELISAs) are plate-based assays designed for detecting and quantifying substances such as peptides, proteins, antibodies and hormones. Other names, such as enzyme immunoassay (EIA), are also used to describe the same technology. In an ELISA, an antigen must be immobilized to a solid surface and then complexed with an antibody that is linked to an enzyme. Detection is accomplished by assessing the conjugated enzyme activity via incubation with a substrate to produce a measureable product. The most crucial element of the detection strategy is a highly specific antibody-antigen interaction. There are three methods of ELISA. Each type of ELISA can be used qualitatively to detect the presence of antibody or antigen. Alternatively, a standard curve based on known concentration of antibody or antigen is prepared, from which the unknown concentration of a sample can be determined.
14 October 2012

A Review Green biotechnology - a help to the environment

About Authors:
Kiran K.Vaghasiya*, Alpesh J.Shiroya
Bhagwan Mahavir College Of Biotechnology ,
Surat
*vaghasiyakiran51@yahoo.co.in

Abstract
Green biotechnologydeals with the use of environmentally-friendly solutions as an alternative to traditional agriculture, horticulture, and animal breeding processes. An example is the designing of transgenic plants that are modified for improved flavor, for increased resistance to pests and diseases, or for enhanced growth in adverse weather conditions. Genetically enhanced crops are one tool that could contribute to a more harmonious balance between food production and our surrounding environment. The overall message is that biotech plants can, and already do, contribute positively to reducing CO2 emissions and anticipating the impact of climate change on food scarcity. This will increase as they are more widely adopted. This document aims to provide background information about the role green biotech currently plays, and can play in future, in helping to combat climate change.
12 October 2012

THE DETAIL STUDY OF LANTANA CAMARA PLANT FOR THEIR MEDICINAL IMPORTANCE -A REVIEW

About Authors:
HH SAPARIA*, M BAIDYA, AR MAHESH
Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post,
Varthur Hobli, Banglore-560035, Karnataka, India.
*hiteshsapariya29@gmail.com

Abstract:
Current advancement in drug discovery technology and search for novel chemical diversity have intensified the efforts for exploring lead from “Ayurveda” the traditional system of medicine in India. Lantana camara, Family: Verbenaceae has been important coniferous plant in ayurvedic and indigenous medicinal systems. The Clinical trials and animal research support the use of Lantana camara for anti-spasmodic, carminative, anti-tumour, anti-inflammatory, anti-malarial, anti-ulcer genic, treatment of emotional stress and trauma, anti-microbial, insecticidal, fungicidal, asthma. Major biochemical constituents of Lantana camara were identified as alkaloids/flavonoids, saponins/tannins, germacrene-A, B and D, triterpenes like lantadenes-A, B, C, D, valencene (principle constituent) and γ-gurjunene, verbascoside, martynoside.This paper includes the evidence-basedoverview of pharmacological and phytochemical properties of the aerial parts of Lantana camara.

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12 October 2012

FORMULATION AND EVALUATION OF SUSTAINED RELEASE GUAR GUM MATRIX TABLETS OF METFORMIN HYDROCHLORIDE

About Authors:
Shaik .Shabbeer*, V.Sruthi, P.Usha, K.Mahesh
Department of Pharmaceutical sciences, Swami Ramananda Tirtha Institute of Pharmaceutical Sciences,
Nalgonda, Andhra Pradesh, India-508001
*shkshabbeer@yahoo.com
11 October 2012

ALL ABOUT COSMETICS

About Authors:
Ms.Roseline
MBA, B.Pharm.
Independent Cosmetic Consultant.
Hyderabad.
g.roseline28@gmail.com

ABSTRACT
The Indian cosmetic Industry has witnessed rapid growth over the last couple of decades. In that time the range of cosmetic and beauty products in India has widened tremendously. Beauty products manufacturers in India mostly cater to the great demand for cosmetics and toiletries that fall into the low or medium-price categories as the greatest demand in India has always been for these economically priced products.
However, in recent years in the cosmetics market India competitors have begun to manufacture products to cater to an International need. For instance, herbal cosmetics from India have a great demand in the overseas market and many cosmetic products that are manufactured in India today are supplied to international suppliers of branded cosmetics products like The Body Shop for example. New facts that have been unveiled by a series of cosmetics business market analysis India reveal that many International companies are now outsourcing cosmetics to India and that the industry of cosmetic products India is growing at an average rate of almost twenty percent annually. This increase is attributed to two main factors. The first being the increase for the demand in Indian cost-effective products and the second being the increased purchasing power of the average Indian.
11 October 2012

SIMULTANEOUS DETERMINATION OF IMIDAZOLE IN 2 METHYL IMIDAZOLE BY REVERSE PHASE LIQUID CHROMATOGRAPHY

About Authors:
Chandorkar J.G.
Head, Analytical development laboratory
Indofil Industries Limited
Thane.
jchandorkar-icc@modi.com

Abstract-
2 methyl Imidazole is the active raw material in the manufacturing of Micanazole Nitrate, Ketokenazole type Active pharma ceuticals. Imidazole is the Impurity which get form during manufacturing of 2Methyl Imidazole.
The Proposed Method is to determine the Impurity as well as Content in 2 Methyl Imidazole.
10 October 2012

GOOD DISTRIBUTION PRACTICES-EXPECTATIONS FOR COMING DECADE

About Authors:
Middha Akanksha*, Kataria Sahil, Kukkar Vipin
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
*Akankshamddh@gmail.com

Abstract
Good Distribution Practice (GDP) deals with the guidelines for the proper distribution of medicinal products for human use. GDP is a quality warranty system, which includes requirements for purchase, receiving, storage and export of drugs intended for human consumption.

GDP regulates the division and movement of pharmaceutical products from the premises of the manufacturer of medicinal products, or another central point, to the end user thereof, or to an intermediate point by means of various transport methods, via various storage and/or health establishments.
10 October 2012

INDUSTRIAL PREPARATIONS AND STANDARDIZATION OF HERBAL MEDICINES

About Authors:
Kapil Sharma*, Priyanka Sharma
Yaresun Pharmaceutical Pvt. Ltd.,
India.
*pharma_kapil@rediffmail.com

ABSTRACT
Herbalism is a traditional medicinal or folk medicine practice based on the use of plants and plant extracts. Many plants synthesize substances that are useful to the maintenance of health in humans and other animals because herbal medicine have harmless advantages. Humans, and even neanderthals, have used plants to treat their ailments for at least tens of thousands of years; most likely even longer than that. The first written accounts of the use of herbs originate in china, although all other civilizations from the ancient world were using plants as natural remedies for their ailments. Western herbal medicine dates back to ancient greece and its famous doctors like hippocrates and galen.The 15^th to 17^th centuries were the most popular time for herbalism in europe. Herbal remedies are still relatively popular today, mainly due to the fact that they are regarded as harmless because they are natural. So this paper describe basic information involved in preparation of herbal remedies for internal use and for external useand gives a detail account about standardization and evaluation in formulations of herbal drugs.

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9 October 2012

VALIDATION AND SECURITY MEASURES FOR PHARMACEUTICAL DATA PROCESSING

About Authors:
Krunal Parikh^1*, Maheshkumar Kataria²
¹ M.Pharm, Quality Assurance,²Assistant professor, Department of pharmaceutics,
Seth G.L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
*Krunal_2922@yahoo.in

ABSTRACT
The Quality System regulation requires that “when computers or automated data processing systems are used as part of production or the quality system, the manufacturer shall validate computer software for its intended use according to an established protocol.” This has been a regulatory requirement for GMP since 1978. In addition to the above validation requirement, computer systems that implement part of a regulated manufacturer’s production processes or quality system (or that are used to create and maintain records required by any other FDA regulation) are subject to the Electronic Records, Electronic Signatures regulation. This regulation establishes additional security, data integrity, and validation requirements when records are created or maintained electronically. These additional Part 11 requirements should be carefully considered and included in system requirements and software requirements for any automated record keeping systems.