Articles

About Author:
Kambham Venkateswarlu
Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chottoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
Malaria is an infectious disease caused by a parasite (plasmodium) which is transmitted from human by the bite of infected female Anopheles mosquitoes. Four species of the parasite plasmodium are responsible for Malaria in humans: Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Plasmodium falciparum.
This disease cause a nearly 300 to 400 million clinical episodes of malaria occur worldwide, out of which 1.5 to 2 million die every year. So this is also a most dangerous disease in children. This review reveals the treatment of malaria in paediatrics.

About Authors:
Shaishavi Parikh*, Arun Parikh, Vijayalakshmi Gudaparthy
Department of pharmaceutical chemistry, L. J. Institute of Pharmacy,
Ahmedabad-382210, India.
*shaishavi21@rediffmail.com

Abstract
Thiazolo[3,2-a]pyrimidine were synthesized by the reaction of the indole aldehyde with thiourea and methyl isobuterylacetate to generate thioxo pyrimidine compound which condensed to phenacyl bromide to form thiazolo[3,2-a]pyrimidine. All synthesized compounds are characterized by the IR, Mass and NMR spectroscopy and evaluated for the antibacterial and anti fungal activity by using B. cereus, S. aureus strains of Gram positiveE. coli strain of Gram negative andC.albicans strain of fungus. The compound having nitro and methoxy substituent shows significant activity in thiazolo[3,2-a]pyrimidine derivatives.

About Author:
Dipak Kumar Dash
M Pharm pharmaceutics
Production officer -Akorn india pvt ltd
dipak.dipak.dash@gmail.com

INTRODUCTION
Introduction In recent years, polymeric controlled drug delivery systems have evolved as one of the most attractive areas in drug delivery research. The drug release is controlled by properties of the polymer-drug system and also by other factors like pH, enzymes etc. Despite several advantages offered by the controlled drug release, one important problem pertinent to the entire field is that all the systems so far developed give release rates that are constant or decrease with time.Increased delivery on demand will be very beneficial in situations like, delivery of insulin for patients with diabetes mellitus, antiarrythmics in case of heart disorders and nitrates in case of angina pectoris. This increased delivery on demand can be achieved by using external feed back control systems such as magnetic control. The concept of magnetically controlled drug delivery for the first time was proposed be Tyle in 1988. A system has been developed to magnetize the carriers so that these particles can be retained on the target site by the application of an external magnetic field of appropriate strength. Magnetic fields are believed to be harmless to biological systems and adaptable to any part of the body.

About Authors:
Narasimha Murthy Yedulapurapu*, Babu Rao. Chandu
Donbosco P.G. College of Pharmacy, 5th mile,
Pulladigunta, Kornepadu (V), vatticherukuru (M),
Guntur, Pin code: 522017, Andhra Pradesh.
*Murthyvedulapurapu@gmail.com

ABSTRACT:
Cefixime Trihydrate is an orally active third generation cephalosporin. It has plasma half-life of 3-4hrs; it is active against Gram+ve as well as Gram-ve bacteria. The present investigation involves the enhancement of dissolution rate of cefixime by using various solid dispersion techniques with a view to prolong the drug release in the gastrointestinal tract and consequently into the plasma. The solid dispersions were formulated by using the Croscarmelose sodium as a disintegrant. The solid dispersions were prepared by solvent evaporation, kneading, Physical mixing, Co-grinding techniques. In solvent evaporation technique, Dichloromethane is used as a solvent and in kneading technique water is used as solvent. The prepared solid dispersions were evaluated for in-vitro dissolution studies. Among the 5 formulations F5 sows the good results.

About Author:
Kambham Venkateswarlu
Final Year Graduate student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India
k.v.reddy9441701016@gmail.com

ABSTRACT:
Electrophoresis is also called as cataphoresis. It is the motion of dispersed particles relative to a fluid under the influence of spatially uniform electric field. This electro kinetic phenomenon was observed for the first time in 1807 by Reuss (Moscow State University), who noticed that the application of a constant electric field caused clay particles dispersed in water to migrate. It is ultimately caused by the presence of a charged interface between the particle surface and the surrounding fluid. Electrophoresis is a rapid separation technique.Factors governing the migration of ions are Charge of ions, Size of the ions, Viscosity of the medium, Voltage applied, pH of buffer and ionic strength. Factors affecting electrophoresis are Molecular characteristics (size, shape), Buffer Properties, Electric Field Characteristics, Temperature.

About Author:
Kambham Venkateswarlu
1-Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chottoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
Hepatitis is a general term meaning inflammation of the liver and can be caused by a variety of different viruses such as hepatitis-A, B, C, D, and E. Since the development of jaundice is a characteristic of liver disease, a correct diagnosis can only be made by testing patient’s sera for the presence of specific anti-viral antibiotics. Transmission of HAV is typically by the faecal, oral route. Hepatitis A was formerly called infectious hepatitis, Epidemic hepatitis, Epidemic jaundice, Catarrhal jaundice, type A hepatitis, HA.

About Author:
Kambham venkateswarlu
graduate student
Sri lakshmi narasimha college of pharmacy,
palluru, chittor-517132, andhra pradesh, india
k.v.reddy9441701016@gmail.com

ABSTRACT:
Nanotechnology is the technology of nanoparticles which are made of polymers of synthetic or natural origin. Nanoparticle is a collective name for nanospheres and nanocapsules of size from 10-1000nm. Nanocapsules are vesicular systems in which drug is confined to a cavity surrounded by a unique polymer membrane. Nanospheres are matrix systems in the drug are physically and uniformly dispersed. Nanotechnology is the design, characterization, production on and application of structures, devices and systems by controlling shape and size on the nanoscale. Nanotechnology in medicine is referred to as nanomedicine and involves the implementation of technologies that exist or function at the cellular and levels medical use.