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  • A COMPARATIVE STUDY FOR SAFETY AND EFFICACY OF OXACEPROL AND DIACEREIN IN OSTEOARTHRITIS OF KNEE JOINTS

  • REGULATORY AFFAIRS: STUDY REPORT OF NEW DRUG REGISTRATION PROCESS IN EUROPEAN UNION
  • IMPACT OF OBESITY ON PULMONARY FUNCTION TEST IN SCHOOL CHILDREN

    About Authors:
    Madhuri Sharma*1, KC Mathur1, Rajnee2, Raaz K Maheshwari3
    1Department of Physiology, Sardar Patel Medical College, Bikaner, Rajasthan
    2Department of Physiology, Sarojini Naidu Medical College, Jodhpur, Rajasthan
    3Department of Chemistry, SBRM Govt PG College, Nagaur, Rajasthan
    *madhurisharma26@gmail.com

    Abstract
    Pulmonary function test are affected by the obesity. Various studies demonstrate important modifications in the pulmonary function tests of obese adults and adolescents, there is scarce information on obese children, and the findings remain inconclusive. Although there are some studies which demonstrate important modifications in the respiratory pattern of obese children, but there are some contradictory findings. So such type of study should be done which give us different and separate findings for overweight, mild obese, moderately obese, and morbidly obese criteria in obese school children in comparison with age, sex and ethnically matched control group.

  • ANTIULCER ACTIVITY OF ANNONA SQUAMOSA SEED EXTRACT IN EXPERIMENTAL RATS
  • EVALUATION OF DIURETIC ACTIVITY OF GLYCYRRHIZA GLABRA LINN IN EXPERIMENTAL ANIMALS
  • FORMULATION, DEVELOPMENT AND EVALUATION OF ANTI-IMPLANTATION ACTIVITY OF INTRAUTERINE SYSTEM OF CENTCHROMAN (SAHELI) USING WISTAR ALBINO RATS
  • POLYPHARMACY IN GERIATRICS

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    About Authors:
    T. Vishnuvaravidyadhar*, M. Sushma, R. Mohanraj, M. Babu  
    Department of Pharmacy Practice,
    Raghavendra Institute of Pharmaceutical Education & Research, RIPER
    K R Palli Cross, Near S.K University,
    Anantapuramu District, Andhra Pradesh, INDIA

    *vishnuvaravidyadhar@gmail.com

    Abstract:
    Geriatrics is more prone to higher risks of chronic illness and are using multiple medications in order to lead healthy life. Polypharmacy increases the risk of adverse drug events, as a result changes takes place in physiological, social, physical and functional decline in the body. These rapid physiological changes make elderly patients unable to cope with body stresses. Drug toxicity, side effects and adverse drug reactions appear more frequently and are more life-threatening in elderly patients. Tetracyclins, streptomycin, reserpine, and all barbiturates are to be contraindicated in geriatrics in order to prevent further complications. Polypharmacy is the simultaneous taking of many medications, has been well documented and is a topic of much concern for those looking to improve the quality of care for the elderly. Elderly patients often develop complicated conditions and multi-factorial health states that require extensive pharmacotherapy, sometimes surgery leaving the population at risk for exposure to drug-drug interactions, drug-food interactions and other adverse events. Previously literature states that rate of adverse events are directly proportional to number of drugs taken by the patient. To manage all these complications and to avoid polypharmacy Dose regimen should be simple and drugs should be given in combinations to improve patient compliance.

  • A REVIEW ON GAS GANGRENE AND ITS MANAGEMENT
  • PROSTAGLANDINS AND ITS TYPES

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    About Authors:
    S. Ramya Silpa
    Department of Pharmacology,
    Balaji College of Pharmacy, Anantapur, AP, India.
    shilpasankarapu@gmail.com

    Abstract:
    Prostaglandins are potent bioactive lipid messengers synthesized from arachidonic acid mediated by enzyme COX. Prostaglandins (PGs) play a key role in the initiation of the inflammatory response. Their biosynthesis is significantly increased in inflamed tissue, and they contribute to the development of the cardinal signs of acute inflammation. Although the proinflammatory properties of individual PGs during the acute inflammatory response are well established, their role in the resolution of inflammation is more controversial.

  • RESEALED ERYTHROCYTES - AS A CARRIER

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    ABOUT AUTHORS:
    Meenu Sharma*, Saroj  jain
    Department of Pharmaceutics, Hindu college of pharmacy
    Panchayat Bhawan, Gohana Road, Sonipat (Haryana)
    meenu99sharma@gmail.com

    ABSTRACT
    Amongst various carriers explored for target oriented drug delivery, vesicular, microparticulate and cellular carriers meet several criteria rendering them useful in clinical applications. Lymphocytes, leukocytes, platelets, granulocytes and erythrocytes have been  proposed as a cellular carriers.  Erythrocytes, also known as red blood cells, and have been the most extensively investigated and found to possess great potential in novel drug delivery. The biocompatibility, non- pathogenicity, non-immunogenicity and biodegradability make them unique and useful carriers. The prime function of these RBCs is to transport gases for respiratory processes. Carrier erythrocytes are prepared by collecting blood sample from the organism of interest and separating erythrocytes from plasma. By using various methods the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called "resealed erythrocytes". Erythrocytes have been proposed as a carriers for a wide range of bioactive components including drugs enzymes, pesticides, DNA molecules and others.

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