Formulation, Development and Evaluation of Anti-Implantation Activity of Intrauterine System of Centchroman (Saheli) using Wistar Albino Rats

  • Posted on: 1 May 2014
  • By: admin

 

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PharmaTutor (May- 2014)
ISSN: 2347 - 7881

 

Received On: 20/03/2014; Accepted On: 27/03/2014; Published On: 01/05/2014

 

Author: Himani Devliyal*, S.S Agarwal
Department of Pharmacology,
Delhi Institute of Pharmaceutical Sciences and Research, Delhi University, New Delhi
himanidevliyal@gmail.com

 

ABSTRACT:
Centchroman – A Non-steroidal, post-coital anti-implantation drug which is generally popular as SAHELI is one of the best agents available. The fundamental aim of this study  was to formulate such an Intra-uterine System of Centchroman which should be safe and acceptable. This new drug delivery system surpasses the first pass metabolism, thus increasing the bioavailability and reducing the drug load. This formulation delivered the drug upto 21 days. Polylactic-co-glycolic acid served as the best fit polymer for delivering the drug. The best optimized formulation was selected and subjected to stability studies. The effect of the foreign bodies was also observed on the fertility, mating behaviour and estrous cycle of the rats along with anti-implantation activity of the IUS. This formulation was tested on Wistar albino rats and is proved to be safe at the optimized dose level. The formulation exhibited pre-implantation loss of 100% and post-implantation loss of 0% in Wistar albino rats at a particular dose when delivered on 1st day and 4th day post-coital. Experimental part on animals showed that any foreign body, if put inside the uterus would not affect the fertility unless the size is more than 6mm. Results showed that 3mm objects had no effect on fertility. The foreign bodies and the IUS showed neither any alteration in the estrous cycle nor on the mating behavior of the animals.

How to cite this article: H Devliyal, SS Agarwal; Formulation, Development and Evaluation of Anti-Implantation Activity of Intrauterine System of Centchroman (Saheli) using Wistar Albino Rats; PharmaTutor; 2014; 2(5); 128-132

 

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