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Sarepaka a.*1, Dhamodaran p.1, Singh a.2, Nilani P.1, Duraiswamy B1
1Department of Pharmacognosy, JSS College of Pharmacy, Ootacamund, Tamilnadu, India 643001
2Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund, Tamilnadu, India 643001
World Health Organisation (WHO) recommends The Directly Observed Treatment Short-course (DOTS) strategy of tuberculosis (TB) treatment which includes a course of first line as well as second line antibiotics. Unfortunately, from nearly the moment drugs became available for the treatment of TB, resistance became a problem. Also, the price of these medications is high; thus poor people in the developing world have no or limited access to these treatments. Herbal treatment, however, presents the potential to provide an affordable, available, culturally relevant method to manage tuberculosis. Currently, botanicals are the most competent way to bridge the gap between isolated developing cultures and modern science. As botanicals attain a more prominent role in modern health care, the quality, safety and activity of these products must be assessed. The tribal medicinal men of Nilgiris district use commonly available plants for the treatment of tuberculosis. In this study, we evaluated five such plants for their antitubercular activity in vitro, namely,Withania somnifera, Allium cepa, Zingiber officinale, Glycyrrhiza glabra andAsparagus racemosus, individually as well as in combination. The results revealed that the combination of these extracts have significant inhibitory effect Mycobacterium tuberculosis growth.
Buddhi Bal Chidi
Department of Pharmacy,
Maharajgunj Medical Campus, Institute of Medicine,
Tribhuvan University, Kathmandu, Nepal
Demand of herbal medicine had increased incredibly now a days. Medicine from part of herbal product is found highly efficacious and potent for curing diseases. These products are considered significantly for particular purpose as they show good pharmacological activities. This article gives an idea of basis of Cordyceps sinensis. It is a well known valued traditional medicine which perform nourishing tonic. To date, it is believe that it possesses potential pharmacological action on human body like Anti-inflammatory, Antioxidant, Hyperglycaemia, Sexual dysfunction, Immunomodulating effects, Asthemia, Heart ailment, Hepatoprotective, Immunoresponse, Hyperlipidemia / Hypercholesterolemia, Anti-cancer, Anti-bacterial, Anti-fungal, Anti-hypertensive, Anti-spasmodic, Adaptogenic, Adreno-tonic. This article contains more generalization about O. sinesis which would be better informative.
Gurvinder Pal Singh
Senior Lecturer, Department of Pharmacognosy,
Adesh Polytechnic College, Sri Muktsar Sahib, Punjab
An antioxidant is a molecule capable of slowing or preventing the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent. Oxidation reactions can produce free radicals, which start chain reactions that damage cells. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions by being oxidized themselves. As a result, antioxidants are often reducing agents such as thiols, although oxidation reactions are crucial for life, they can also be damaging; hence, plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, vitamin C, and vitamin E as well as enzymes such as catalase, superoxide dismutase and various peroxidases. Low levels of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress and may damage or kill cells (Sies H., 1997).
Sudheer kumar Kandibanda
Biju Patnaik University of Technology & Sciences(BPUT)
The pharmaceutical sector is focused on development of new drugs and plant based drugs through investigation of leads from traditional system of medicine Ayurveda which is being practiced for thousands of years. Bauhinia variegata is a species of flowering plant in the family Fabaceae. Bauhinia variegata is native to southeastern Asia, from southern China west to Pakistan and India. The major chemical constituents of the plant was found to beflavone, 5,7-dimethoxy-30, 40-methylenedioxy flavone and a new dihydrodibenzoxepin,5,6-dihydro-1,7-dihydroxy-3,4-dimethoxy-methyldibenzoxepin, flavonolglycoside, triterpene saponin, phenanthraquinone, flavonoids.
Department of Pharmacy
Bengal School Of Technology, Hooghly, India
Plant materials have been used as medicine for a wide varity of human ailments due to increase cost of treatments, side effects of several allopathic drug and development of resistance to currently used drug for infectious disease. Cornsilk (Zea mays) is an herbal remedy made from stigmas, the yellowish thread-like strands found inside the husks of corn. Cornsilk is used to treat urinary tract infections and kidney stones in adults. Cornsilk also served as a remedy for heart trouble, jaundice, malaria, and obesity.
ANTI-HISTAMINIC AND ANTI-SPASMODIC POTENTIAL OF ETHANOLIC EXTRACT OF TEPHROSIA PURPUREA (Linn.) PERS. AERIAL PARTS
Paresh Lallubhai Gajera*, Dalal Mittal V.
Department of Pharmacology, ROFEL,
Shri G. M. Bilakhia College of Pharmacy,
The aim of present study was to evaluate anti-histaminic and anti-spasmodic potential of ethanolic extract of aerial parts of Tephrosia purpurea (Linn.) against experimental animal models. In this study ethanolic extract of aerial parts of Tephrosia purpurea (L.) was prepared and anti-histaminic and anti-spasmodic activity evaluated on isolated goat tracheal chain and rat ileum preparation by dose response curve of histamine and acetylcholine in absence and in presence of ethanolic extract was plotted respectively. The results of present study revealed that EETP inhibits moderately significant (*p <0.05) percentage contraction at 50µg/ml while EETP inhibits significantly (**p<0.01) percentage contraction at 100µg/ml induced by histamine (10µg/ml) and acetylcholine (1µg/ml) in isolated goat tracheal chain and rat ileum preparation respectively. To, concluded, EETP possesses dose dependent antihistaminic and antispasmodic potential. However, future studies are required to focus on the molecular mechanism of responsible phytochemical constituents and establish exact mode of action involved in it.
Gayatri Collage Of Pharmacy,
Present study was carried out to scientifically evaluate the anthelmintic potential of the methanolic extract of leaves of the plant morus alba(L) as it is used by the tribal community of different states and this is also highlighted in traditional uses of the plant. Activity was performed using adult earthworms and albendazole was used as a standard. Various doses (2.5, 5, 10 mg/ml) of methanolic extracts of leaves were used for the study. From results of the study it is clear that potency of the extracts is inversely proportional to the time taken for paralysis and death of worms. All the tested doses showed significant activity (P<0.01) compared to the standard and activity also confirms dose dependant nature of the extracts.
Shristi Badhani*, Shivani Sharma, Amrita Kainth, Bharat Parashar
Department of Pharmacy,
Manav Bharti University, Solan, H.P.
Hepatic diseases are a major worldwide health problem, with frequently found in developing countries. They are mainly caused by uses of high doses of chemicals and some drugs. There is no effective drug available that stimulates liver function, offer protection to the liver from damage or help to regenerate hepatic cells. Therefore there is urgent need, for effective drugs to replace/add those in current use. Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytoconstituents from some medicinal herbs and those medicinal herbs have proven hepatotprotective potential.A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system. In this century clinicalresearch has confirmed the efficacy of some herbs in the treatment of liver related disease. Hence, this review article contributes to the knowledge of reported indigenous plants, which are prevalent for prevention and treatment ofliver disorders.
Das Sattwik1, Sharma Shikha1, Lariya Shailendra2
1Malhotra College, Department of pharmacology, Badwai, Bhopal, M.P., India
2Radha raman Institute of Pharmaceutical Science, Bhopal, M. P., India
Ixora parvifloraan Indian plant, has long been medicinally used in traditional systems of medicine. The plant has been found to possess varied number of pharmacological activities. This article gives an account of updated information on its phytochemical and pharmacological properties. The review reveals that wide numbers of phytochemical constituents have been isolated from the plant which possesses activities like anaemia, whooping cough, antiviral, hypotensive and spasmolytic. These reports are very hopeful and indicate that the plant should be studied more widely for its therapeutic effects.
Vemavarapu Satish kumar*, Shahin1 , Saarangi Ramesh2
*IPQC team member at GRANULES INDIA LIMITED, M.Pharmacy (pharmaceutics) Deevena college of pharmacy.
1Shadan women’s college of pharmacy. khairtabad, Hyderabad. A.P
2asst.prof.pharmaceutical chemistry, Prasad institute of pharmaceutical sciences. jangaon, warangal. A.P
1 GEOGRAPHICAL SETTING
1.1 Ficus religiosa
Origin of the tree is not really known to anybody, but, there are also some interesting legends associated with the Peepal tree. The peepal is the first-known depicted tree in India. A seal discovered at MohenjDaro, one of the cities of the Indus Valley Civilisation (c. 3000 BC - 1700 BC), shows the peepal being worshipped. Excavations are suggestive of the fact that even in those times; the peepal tree was worshipped by Hindus.
Peepal is native from India to southeast Asia and it is found wild and cultivated upto 5000 feet. Ficus religiosa is cultivated in various tropical areas of the world. It is grown in southern California, Florida and Hawaii, Homestead and Miami in the United States.
Regardless of its origin, the tree needs lots of space, and the soil must be deep enough to let the roots grow down a long way. It is a large tree of about 20 m. heights with a well developed crown. It can grow in a wide variety of soils and it grows in a sub tropical climate with hot summers and frost during the monsoon season.