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  • A REVIEW ON RECENT TRENDS IN ORAL DRUG DELIVERY- MOUTH DISSOLVING FORMULATION

    ABOUT AUTHORS:
    Manish Goswami, U.K.Singh, Rajat Kumar
    Kharvel subharti college of pharmacy (swami Vivekanandsubharti University) Subhartipuram,
    N.H-58, Meerut By Pass Road,
    Meerut, uttarpradesh- 250001, India.
    *manish.revosys88@gmail.com

    ABSTRACT:
    The desire of improved palatability in orally administered products has prompted thedevelopment of numerous formulations with improved performance and acceptability. Mouth dissolving tablets (MDTs) have received ever-increasing demand during the last fewdecades, and the field has become a rapidly growing area in the pharmaceutical industry. Theunique property of mouth dissolving tablet is that they are rapidly disintegrating and/ordissolving and release the drug as soon as they come in contact with saliva, thus obviate therequirement of water during administration. this review also provides the detailed concept of some unique patents; technologiesdeveloped and marketed formulations of Mouth Dissolving Tablets(MDTs).The present investigation was undertaken with a view to develop mouth-dissolving tablets which offer a new range of product having desired characteristics and intended benefits. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The basic approach used in development of MDT is the use of super disintegrants like Crosslinked carboxymethyl cellulose (Croscarmellose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. whichprovide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva.

  • AN OVERVIEW: ON SUPERDISINTEGRANTS

    ABOUT AUTHORS:
    Rahul Tiwari*1, R.C. Jat1, Narendra Sharma1, Arvind Singh Rathore1
    1Shri Ram College Of Pharmacy,
    1Banmore, Morena, India -476444
    *rt30022@gmail.com, arvindsingh.rathore21@gmail.com

    ABSTRACT
    Disintegrants are substances or mixture of substances added to the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. In dosage forms, solid orals gain maximum popularities, about 85%, because of many advantages over others. The therapeutic activity of these formulations is obtained through a typical manner like disintegration followed by dissolution. Hence disintegration has major role for facilitating drug activity and thus gain popularity among other dosage forms. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1-  10 % by weight relative to the total weight of the dosage unit. The present study comprises the various kinds of superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance. In this review article, more emphasis is given on application and usage of various superdisintegrants comparing with other disintegrants in reference to available scientific studies. The various sources of superdisintegrants and their modification to improve disintegration property are also high-lighted.

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  • A SHORT REVIEW ON FAST DISSOLVING TABLETS - A NOVEL DRUG DELIVERY SYSTEM

    ABOUT AUTHORS:
    Yedale A.D.*, Waghmare P.V, Kulkarni S.D., Bhusnure O.G., Bhalekar M.S.
    Master of pharmacy, Department of Quality Assurance
    Maharashtra College of Pharmacy, Nilanga, dist. Latur (MS) 413521, India
    *ajayyedale03@gmail.com

  • COLON TARGETED DRUG DELIVERY SYSTEM

    ABOUT AUTHOR:
    Sunitha Manthena
    Nalla Narsimha Reddy School of Pharmacy,
    Narapally, Hyderabad
    Affiliated to JNTU(H);
    sunithatgk@gmail.com

    INTRODUCTION
    The expenses for developing new drugs are exorbitant. Thus in the present scenario, more emphasis is laid  to develop newer drug delivery technologies, which would ensure better patient compliance, drug efficacy and extends the term of patents of the existing molecules. In the present era, the pharmaceutical industry is facing several challenges due to worldwide competition and growing demand for better products.1

  • REVIEW: TABLET COATING PROCESS

    ABOUT AUTHOR
    Abhijeet Welankiwar

    Govt. College of pharmacy, kathora naka,
    Amravati (Maharashtra) 444604
    abhi123welankiwar@gmail.com

    ABSTRACT:
    Tablet coating is the key step involved in the manufacturing of tablets having controlled release, delayed release profiles. The tablet coating have number of advantages like masking odor, taste, color of the drug, providing physical and chemical protection to drug, Protecting drug from the gastric environment. 3 primary components of tablet coating are tablet properties, coating process and coating composition. Tablets are usually coated in horizontal rotating pan with coating solution is either directly poured or sprayed on to them. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Recent trends in tablet coating focuses on overcoming disadvantage of solvent based coating. This article concerns with the coating process, equipments involved, coated tablets evaluation and specialized coating techniques.

  • DOMPERIDONE NASAL GEL USING NATURAL MUCOADHESIVE AGENT OBTAINED FROM TAMARIND SEEDS

    About Authors:
    Dharmendra Kumar*, Bhanu Priya, Sumedha Bansal,
    Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
    Meerut, Uttar Pradesh, India, 250005

    * rvnimiet@gmail.com

    Abstract
    A new Nasal drug delivery system of Domperidone has been developed as decent drug delivery by using natural mucoadhesive agent extract from Tamarindus indica L. The mucoadhesive strength, pH, viscosity and gelling property of this natural mucoadhesive agent was found to be higher in comparison to synthetic polymers, hydroxy propyl methyl cellulose (HPMC) and carbopol which are conventionally used for similar purpose. In vitro drug release characteristic through franz-diffusion cell using excised bovine nasal membrane was also found to be better in comparison to the above synthetic polymers. Now patient friendly, needle free dosage form may replace the Domperidone injections/ tablets in future.

  • Dendrimers:-A Carrier for oral drug delivery system

    About Author
    Manish kumar
    Hindu College Of Pharmacy, Sonipat
    *maggarwal0007@gmail.com

    Abstract:
    Dendrimers are perfect monodisperse macromolecules(poloymers) with regular and highly branched 3-D structure. Dendrimers have often been referred to as the “Polymer of the 21st century. They are characterized by branch upon branch architecture which are completely different from traditional Polymers. Exceptional feature of a dendrimer includes a high degree of structural symmetry, a density gradient displaying an intra-molecular minimum value and a well defined number of terminal groups. Dendrimers are normally used as carriers for drug delivery especially for oral, ocular and transdermal delivery. Oral drug delivery system are very important to the field of medicine, since most of the common illness are treated via oral route. Encapsulation and conjugation of drug with dendrimers have shown immerse employment for delivery of hydrophobic and labile drugs. Anticancer and antihypertensive drugs are most promising candidates for oral route using dendrimer as carrier. Dendrimers drug delivery system are therefore increasingly viewed as an advantageous for bioactive like drugs and gene. Although dendrimer drug delivery requires attention to certain manufacturing and biological consideration to be successful.

  • COMPARATIVE STUDY OF DRUG PRODUCT RECALL REGULATIONS IN USA, UK AND AUSTRALIA AND DRAFT GUIDELINES FOR INDIA

    About Authors: 
    Bane Singh Rajput*
    Research Scholar of Lachoo Memorial College of Science & Technology
    Pharmacy Wing, Jodhpur (Raj.)
    *bnsingh29@gmail.com

    Abstract
    Drug product recall is an action taken to withdraw or remove a batch or an entire production run of a drug product from distribution or use and return them to the manufacturer. It is usually done due to the discovery of deficiencies in quality, efficacy or safety in the marketed drug products. Defective drug products related to quality includes adulterated or spurious drugs. Safety and efficacy related recalls include serious adverse reactions and death. Recalls also include drugs prohibited under the law and also those products for which product licenses are suspended/ cancelled. In USA, guidelines for drug product recall are described under 21 CFR Parts 7, 107 and 1270.  In Australia, guidelines for drug product recall are described under section 65F of the Trade Practices Act 1974. Sections 2(2), 4, 5 and 7 of the European Communities Act 1972 and Directive 2001/95/EC on general product safety are followed in UK for drug product recall. In India, references for drug product recalls, complaint and adverse reactions are mentioned in Para 27, 28 of Schedule M and conditions of license for defective product recall in Rule 74(j) and Rule 78(i) of the Drugs and Cosmetics Act, 1940 and Rules there under. But no effective and uniform recall procedure and guidelines are formulated yet in India. This paper presents a comparative study of drug product recall guidelines in USA, UK and Australia. Based on this comparative study suggestions are provided to develop regulatory guidelines for drug product recall in India.

  • SURFACTANTS AND ITS APPLICATION IN PHARMACEUTICALS: AN OVERVIEW

    About Author:
    Dhananjay S Jadhav*
    M.Tech (Pharmaceutical Technology), Division of Pharmaceutical Technology,
    Institute of Chemical Technology, North Maharashtra University, Jalgaon -425001.
    Maharashtra, India
    * dhananjaysjadhav@hotmail.com

    Abstract
    Recently, surfactants have become one of the most important chemical products. They have become a subject of research, and their production and their use are on the increase. This wide range of properties, uses for surfactants in pharmaceutical products and systems is to try and introduce and explain in the subject of this article. Wetting of Solids, Solubilization, Emulsification, Dispersion of solid in solution, Micellization & Detergency all these are properties of surfactant. Surfactants are classified according to their polar head group, the charged head referred as Ionic surfactants and uncharged surfactants are generally referred to as nonionic surfactant. Because of their unique functional properties, surfactants find a wide range of uses in pharmaceutical preparations. These include, depending on the type of product, improving the solubility or stability of a drug in a liquid preparation, stabilizing and modifying the texture of a semisolid preparation, or altering the flow properties of a granulate, thus aiding in the processing of the final tablet dosage form. In addition to their use as excipients to improve the physical and chemical characteristics of the formulation, surfactants may be included to improve the efficacy or bioperformance of the product. The properties of surfactants are such that they can alter the thermodynamic activity, solubility, diffusion, disintegration, and dissolution rate of a drug. Each of these parameters influences the rate and extent of drug absorption. Furthermore, surfactants can exert direct effects on biological membranes thus altering drug transport across the membrane. The overall effect of inclusion of a surfactant in a pharmaceutical formulation is complex and may be beyond those initially intended. Surfactants may reduce the effectiveness of antimicrobials or preservatives included in a formulation.

  • DESIGN, DEVELOPMENT AND FUTURE APPLICATION OF MICROSPHERES

    About Authors:
    Divya Rawat, U.K.Singh, Faizi Muzaffar
    Kharvel Subharti College of Pharmacy,
    swami Vivekanand subharti university, Subhartipuram,
    N.H-58, Meerut By Pass Road, Meerut, Uttar Pardesh-250001, India
    *drawat05@gmail.com

    Abstract
    Microspheres constitute an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. The range of Techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as micro particles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. The purpose of the review is to compile various types of microspheres, different methods to preparation, its applications and also various parameters to evaluate their efficiency.

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