Pharmaceutics Articles

USE OF NATURAL SUPERDISINTEGRANT IN MOUTH DISSOLVING TABLET

ABOUT AUTHORS:
Mr. Kulkarni Sarang*,Birajdar Shivprasad M., Shaikh Parvej H., Dr. Poul B.N
Maharashtra College of Pharmacy, Nilanga, dist. Latur (MS) 413521, India
*sarangkulkarni342@gmail.com

ABSTRACT
Oral route is the most preferred route for administration of various drugs because it is regarded as safest, most convenient and economical route. Recently researcher developed the fast disintegrating tablets with improved patient compliance and convenience. Fast disintegrating tablets are solid dosage forms which dissolve rapidly in saliva without chewing and additional water. Fast disintegrating tablets overcome the disadvantages of conventional dosage form especially dysphagia (difficulty in swallowing) in paediatric and geriatric patients. Natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, biodegradable and widely available. They can also be modified in different ways to obtain tailor- made materials for drug delivery systems and thus can compete with the available synthetic excipients. With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in their formulations. The natural superdisintegrants can be used instead of synthetic superdisintegrants as they showed equal disintegrating property as that of synthetic agents or dispersible tablets.


A REVIEW ON MOUTH DISSOLVING TABLETS

About Authors:
Chandan bisht1*, Dr.Jagannath sahoo2, Dr.M.Irfan Khan3
1,2 Shri Ram Murti Smarak college of Eng. & Tech( department of pharmacy) Bareilly.
3 Deccan Healthcare pvt. Ltd. Pantnagar industrial area
*chandanbisht2011@gmail.com

Abstract:
Mouth dissolving tablets (MDT) are useful in patients, such as pediatric, geriatric, bedridden, or developmentally disabled, who may face difficulty in swallowing conventional tablets or capsules and liquid orals or syrup, leading to ineffective therapy, with persistent nausea, sudden episodes of allergic attack, or coughing for those who have an active life style. Over the past three decades, mouth dissolving tablets have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance The objective of this article is to review the development of MDTs, challenges in formulation,  benefit, limitation ,new MDT technologies and evaluation methodologies.


PULMONARY DRUG DELIVERY: A REVIEW

ABOUT AUTHORS:
Dr. N.V. Satheesh Madhav, Girish Dwivedi*
Dehradun Institute of Technology, Faculty of Pharmacy
Village Makkawala, Mussoorie Diversion Road,
Dehradun-248009

*Girish10.dwivedi@yahoo.com

ABSTRACT
Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for site specific and systemic treatment. The review is prepared with an aim to discuss about the technical, physiological, and efficacy aspects of the novel pulmonary route of drug targeting and different delivery devices such as metered dose inhalers (MDI), dry powder inhalers (DPI), nebulizers, etc. The review also focuses on the mechanisms of pulmonary drug administration along with compatibility of the excipients employed, devices used, techniques of particulate dosage production, evaluation and advancements in the pulmonary drug delivery. It can be concluded from whole study that different pulmonary delivery system possesses certain specificity for dosage formulations and serves as an important tool to deliver drugs to the target site.


REGULATORY ISSUES AND NATURAL PRODUCTS

About Authors:
Sapna Phadtare,* Vaibhav Shinde, Kakasaheb Mahadik
Department of Pharmacognosy, Poona College of Pharmacy,
Bharati Vidyapeeth University, Erandwane,
Maharashtra, Pune-411038
*sapnaphadtare@gmail.com

Abstract
The world is gifted with wonderful and precious resources such as plants, animals and minerals that form the major part of our medical system. We as humans are so dependent on these natural sources that life without them is beyond imagination. Thus it is of prime importance that we look into the conservation and preservation of natural products. The Indian and international government bodies have developed various laws, rules and conventions to ensure sustainability of such natural products. This article reviews the general laws, rules and regulations developed globally for natural and traditional medicine. Various guidelines like WHO, EMEA, TGA guidelines are looked upon. Some difficulties that are faced regarding regulatory issues of herbal medicines are studied. The Acts like Indian patent Act, Plant Variety Protection Act, Farmer’s rights, terms like Biodiversity and Biopiracy are reviewed in this article.


DRAFTING OF PATENT CLAIMS AND NONOBVIOUSNESS IN PATENT

ABOUT AUTHORS:
Mohit kumar*, Vishal Sachdeva,
Seth G. L. Bihani S. D. College of Technical Education,
Sri Ganganagar (RAJASTHAN) 335001, INDIA
*mohigarg30@gmail.com

ABSTRACT
A well drafted application decides the fate of an invention. Drafting plays a vital role in the success of an invention during its prosecution, management and maintenance during its tenure and turning it into cash. Drafting a patent application is one of the most important and at the same time one of the most difficult process. The applicant or his agent should so draft a patent application that it is granted with an adequate scope or ambit so as to fully serve the business purpose(s) for which the patent is meant to be used. It is here that the importance of drafting the claims in a patent must be fully appreciated, as the drafting of claims must always be done with a clear focus on the exact business needs that are sought to be served by it. That is, a business strategy perspective must inform the thinking of the one who takes up the task of drafting the patent claims. The ultimate purpose of every business strategy is to ensure that a business makes the desired amount of profit to justify the risks taken in making the investments of resources and time. Similarly, the purpose of drafting claims should be to fully serve the business strategy at hand. Even so, only a small number of well drafted patents are actually used by businesses to help them to make or safeguard their profits. (Swarbrick James, 2007).


REVIEW - QUALITY CONTROL OF PARENTERAL PRODUCTS

About Authors:
Abhijeet Welankiwar*, Sushant Tope
Government college of pharmacy Amravati
Kathora naka, amravati (maharashtra) 44460

*abhi123welankiwar@gmail.com

ABSTRACT:
In a pharmaceutical organization a quality control is a fundamental segment that refers to a process of striving to produce a product by a series of measures requiring an organized effort by entire company to eliminate or prevent error at any stage of production. Quality control deals with testing, sampling, specification, documentation, release procedure which ensure that all tests are actually carried out prior to release of material for sale or use. Until its quality judged to satisfactory. This article deals with quality control of parenteral preparation which have 4 basic area that are Sterility, Freedom form Pyrogens, Freedom from particulate matter and leakers. It gives details on each of these 4 Basic areas. The achievement of sterile, non pyrogenic and particulate free parenteral product provides a significant challenge to ingenuity and creativity of parenteral scientist and technologist.


Novel approach of Buccal Drug Delivery System: An Overview

About Authors:
Ranabir Chanda, Saumya Samanta*, Dilip De, Jyotishman Bhattacharya, Anurup Mandal
Bengal School of Technology, Hooghly, West Bengal, India
*samantasaumya7@gmail.com

Abstract
Buccoadhesives have long been employed to improve the bioavailability of drugs undergoing significant hepatic first pass metabolism. Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic drug delivery. The mucosa has a rich blood supply and it is relatively permeable. It is the objective of this article to review buccal drug delivery by discussing the structure and environment of the oral mucosa, mechanism of buccoadhesion,  factors affecting buccoadhesion,  polymers used ,types of buccal dosage form and the experimental methods used in assessing buccal drug permeation/absorption.


ETHYL CELLULOSE BASED GLIBEMCLAMIDE CONTROLLED RELEASE MATRIX TABLETS

ABOUT AUTHORS:
P.PRATHYUSHA*
Department of Pharmaceutics,
Raghavendra Institute of Pharmaceutical and Educational Research,
Anantapur, A.P, India.
* prathyusha2012@gmail.com

ABSTRACT
In the present investigation, an attempt was made to formulate the Oral Controlled Release Matrix Tablets of Glibenclamide in order to improve efficacy, reduce the frequency of administration, reduce dose related side effects and better patient compliance. Four formulations were prepared by wet granulation method using Ethyl cellulose and as a polymer in the ratio of 1:1, 1:2 and 1:4 and Conventional Tablets by using  Starch mucilage as a granulating agent. The formulated granules showed satisfactory flow properties. All the tablets formulation showed acceptable pharmaco technical properties and complied with pharmacopoeial standards. The tablets were evaluated for weight variation, hardness, friability, drug content and invitro dissolution studies. In- vitro release studies were carried out at pH1.2 for first 2 hrs followed by phosphate buffer at pH7.4 over a period of 12hrs using USP dissolution apparatus. F3 shows good initial release of 25.2% in 1 hr and may extend release of 96.8% in 12 hrs. Different release models like zero order, first order, higuchi, Hixson-Crowell and krosmeyer-peppas were applied to invitro drug release data in order to evaluate the drug release mechanisms and kinetics. Formulated matrix tablets were compared with conventional and marketed (diaonil 5mg) formulations. Matrix tablets with optimum concentration of Ethyl cellulose were successfully developed and evaluated.


PERMEATION ENHANCERS - FULL INTRODUCTION: A REVIEW

ABOUT AUTHORS:
DEVENDRA SINGH1*, PANKAJ KUMAR SHARMA1, ROOHI KESHARWANI2, Dr. UDAI VIR SINGH SARA1

1Raj kumar goel institute of technology, Delhi-Meerut Road, Ghaziabad, India
2Chandra shekhar singh college of pharmacy, Kaushambi, Uttar Pradesh, India.

* devendrasingh.pisces@gmail.com

ABSTRACT:
Oral administration still dominates drug therapy and more than 60 % of marketed drugs are oral products. This type of drug administration is preferred due to its convenience, high patient compliance, less stringent production conditions and lower costs. Unfortunately, this traditional drug delivery method has its limitations, due to gastrointestinal permeability, metabolism and elimination of drugs by the liver or gastrointestinal mucosa (first-pass effect). The main drawback of the oral route is that only those compounds that are stable in the gastrointestinal tract can be administered in this way. For this reason, the oral route has been used for mainly non-peptide drugs. Delivery of a drug by oral route is predominantly restricted by pre-systemic degradation and poor penetration across the gut wall. The major challenge in the oral drug delivery is the development of novel dosage forms to endorse absorption of poorly permeable drugs across the intestinal epithelium. In this article we reviewed the various permeation enhancers, histology of small intestine, barriers, application, advantages, some basic permeability enhancement techniques which are useful for enhancing the permeability of poorly permeable drugs


SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE, PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE BY DERIVATIVE SPECTROPHOTOMETRY METHOD

About Authors:
Wagh Vinod. T.
Dept. of Pharmaceutics,
DCS’s. A.R.A. College of Pharmacy, Nagaon,
Dhule-424005 MH. India
wagh.vinod517@gmail.com

ABSTRACT
The simple and accurate method of analysis to determine Glimepiride (GLM), Pioglitazone hydrochloride (PIO) and Metformin hydrochloride (MET) in combined dosage forms was developed using second-derivative spectrophotometry and. GLM, PIO and MET in combined preparations (tablets) were quantified using the second-derivative responses at 233.4 nm for GLM, 265.4 nm for PIO and 252.6 nm for MET in spectra of their solutions in methanol. The calibration curves were linear [correlation coefficient (r) = 0.9990 for GLM, 0.9990 for PIO and 0.9990 for MET] in the concentration range of 5-25 g/ml for GLM, 5- 25 g/ml for PIO and 2- 12 g/ml for MET. The method was validated and found to be accurate, precise, and specific. The method was successfully applied to the estimation of GLM, PIO and MET in combined tablet formulations.


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