Anil kumar vadda1, Lohithasu Duppala2
1AVANTHI Institute of pharmaceutical sciences, pharmacology,
2GITAM Institute of Pharmacy, GITAM University, Pharmaceutics,
visakhapatnam, Andhra Pradesh, India-530045
Rectal drug delivery is an efficient alternate to oral and parenteral route of administration in partial avoidance of first pass metabolism and protein peptide drug delivery. This route allows both local and systemic therapy of drugs. Controlled absorption enhancement of drugs can be achieved by the rectal route because of the constant conditions in the rectal environment. In the present review presents various dosage forms used in rectal route, factors related recatal route of absorption ,fate of drug absorption. This review also presents polymers in rectal route of drug delivery.