Pratapwar A.S1*, Agrawal V.A2
S.N.Institute of Pharmacy Pusad, Yewatmal
Corresponding Author: Agrawal V.A
Out of all the routs of drug administration oral is the most convenient and better for self administration from the patient point of view and suitable for the release controlled delivery systems from the formulators view. In the today’s field of modern drug therapy much more attention is given on the development of oral release modified delivery systems such as programmed release, gastro retentive, floating and most important pulsatile or time programmed release systems. The chronotherapeutic drug delivery systems are designed to maintain the adequate drug concentration according to the needs of the physiological states of patient’s body and the cardian rhythm. Pulsatile release systems are designed to deliver the drug at the right site, at right time and in right concentration after a predetermined lag time. To achieve the desired pulse release pattern, many technological approaches have been investigated like Single unit system,Tablet-Time clocks system, Capsule- Pulsincap system and multiple unit system, Pellets,Time controlled explosion system,Multi-layered Tablet,Chemical stimuli induced pulsatile systems like Glucose-responsive insulin release devices, Inflammation-induced release, intelligent gels responding to antibody concentration, release control by use of the soluble, rupturable, swelling and erodible polymers in the formulation. The present article focus on the basics of chronotherapeutic drug delivery systems, diseases with cardian rethyms, need, advantages, types and approaches for the development of Pulsatile drug delivery systems.