Pharmaceutics Articles

COMPARATIVE DISSOLUTION STUDIES FOR ACECLOFENAC MARKETED DOSAGE FORMS

About Author:
Sowjanya.G
M.pharmacy II year
Annamacharya college of pharmacy,
Rajampet, kadapa dist, a.p, india
Sowji.ces@gmail.com

INTRODUCTION TO DISSOLUTION
A. DEFINITION1

"Dissolution is defined as the process by which solid substances enters in solvent to yield a solution. Stated simply, dissolution is the process by which a solid substance dissolves. Fundamentally, it is controlled by the affinity between the solid substance and the solvent.. "The physical characteristics of the dosage form, the wettability of the dosage unit, the penetration ability of the dissolution medium , the swelling process, the disintegration and the deaggregation of the dosage forms are few of the factors that influence the dissolution characteristics of drugs.


CURRENT CHALLENGES AND FACTORS AFFECTING PRODUCTION PLANNING AND CONTROL IN PHARMACEUTICAL INDUSTRY-A REVIEW

About Authors:
Birajdar Shivprasad M.*, Mulaje S.S., Patil B.R., Sorde M.B., Dr.Bhusnure O.G.
*Maharashtra College of Pharmacy, Department of Quality Assurance, Nilanga-413521,
Dist. Latur (Maharashtra) India
*birajdar100@gmail.com

Abstract:
Production Planning & Control is an important aspect & separate department for any production oriented pharmaceutical industry. The basic objective of the manufacturing organization is to make the products. Thus the production is the nucleus or the centre of entire business operations. It must be emphasized, however, that on signal system of forecasting, preplanning, planning and control is suited to all industrial enterprises, no matter how well it may meet the needs of this on that special company. PPC functions look after the manufacturing activities.


APPROACH OF PRODRUG ON DRUG DESIGN

About Authors:
Mayure Vijay kumar*, V. Sravanthi Yadav, C.P.Meher
Department of Pharmacology,
Maheshwara College of Pharmacy, Chitkul (v), Isnapur “X” Road,
Patancheru, Hyderabad-502307

*mayurevijaykumar@gmail.com

ABSTRACT:
A prodrug is a pharmacological substance that is administered in an inactive (or less than fully active) form, and is subsequently converted to an active pharmacological agent (drug) through normal metabolic processes (bioactivation). A prodrug serves as a type of 'precursor' to the intended drug.Prodrugs can be used to improve how the intended drug is absorbed, distributed, metabolized and excreted (ADME). Prodrugs are often designed to improve oral bioavailability in cases where the intended drug is poorly absorbed through the gastrointestinal tract. A prodrug may also be used to improve how selectively the intended drug interacts with cells or processes that are not its intended target. This reduces the adverse or unintended effects of the intended drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. This review explains about the prodrug.


SOLUBILITY DETERMINATION IN DRUG DISCOVERY AND DEVELOPMENT

About Author:
Dhananjay S Jadhav
*M Tech (Pharmaceutical Technology) Department of Pharmaceutical Technology,  
University Institute  of Chemical Technology,
North Maharashtra University,
Jalgaon -425001. Maharashtra, India.
dhananjaysjadhav@hotmail.com

Abstract
Solubility of drug candidate plays a vital role in selection of lead compound in early stage of drug development and discovery. Biopharmaceutical classification system distributes the drug candidate into different bins depending on the solubility and permeability. Two type of solubility determined at different stages of drug discovery, kinetic solubility and thermodynamic solubility. It is useful in deciding development plan and option of formulation development and to confirm result obtained from kinetic solubility data. Different problem encounter while determining the solubility, most of characteristics usually pH dependent, such as multiple and often overlapping ionization, complexation, aggregation, micelle formation, and “common ion” effect, incubation time, adsorption to micro porous filters, plastic or glass surfaces, polymorph interconversion. Above parameter should be considered while determining solubility. Different method available for measurement of the different solubility, conventional shake flask method now a day’s replaced by the high throughout solubility assay technique which considerably reduces the incubation time increased accuracy of result. Solubility determination can be done by ultraviolet absorption, nephlometry, Nuclear magnetic resonance and Potentiometric in drug discovery. The present review attempts to give a brief account of solubility and it’s importance, process of solubilisation, problems that occur while determining solubility, different types of solubility and there application, parameter to be considered while measuring solubility, different method to measure solubility, application in drug discovery in development, recent advances in solubility measurement.


NOVEL DRUG DELIVERY SYSTEM

About Authors:
Aruna Rastogi
Roorkee College of Pharmacy and UTU
Patanjali Ayurved Ltd, Sr. Chemist
arunarastogi10@gmail.com

1.   INTRODUCTION
1.1 NOVEL DRUG DELIVERY SYSTEM:
The method by which a drug is delivered can have a significant effect on its efficacy. Some drugs have an optimum concentration range within which maximum benefit is derived, and concentrations above or below this range can be toxic or produce no therapeutic benefit at all. On the other hand, the very slow progress in the efficacy of the treatment of severe diseases, has suggested a growing need for a multidisciplinary approach to the delivery of therapeutics to targets in tissues. From this, new ideas on controlling the pharmacokinetics, pharmacodynamics, non-specific toxicity, immunogenicity, biorecognition, and efficacy of drugs were generated. These new strategies, often called drug delivery systems (DDS), are based on interdisciplinary approaches that combine polymer science, pharmaceutics, bioconjugate chemistry, and molecular biology.


“QUALITY-CONTROL”WITH “QUALITY PREMISES” IN PHARMACEUTICAL INDUSTRY

About Authors:
Sharma Monish*, Kumar Bhupender
Seth G.L Bihani S. D. College of Technical Education,
Institute of Pharmaceutical Sciences & Drug Research. Sri Ganganagar,
Rajasthan (INDIA)
*monish28sharma@gmail.com

INTRODUCTION1:  GMP emphasis on the Quality Control on environment and facilities, testing of the materials, components and Product in accordance with the standard.

As Per INDIAN GMP2  :  Following Five elements in the schedule M are  inter-related and these are:
i)       
Factory Premises(location& surrounding, building& premises)
ii)     
Warehousing area;
iii)   
Production area;
iv)   
Ancillary area;
v)     
Quality control area.

WHO Provides Guidelines for Quality Premises who fulfill the following Objectives :-
i)      Suitability of premises to carryout intended operations.
ii)     Minimizing risk of errors.
iii)    Permitting effective cleaning & maintenance.
iv)    Minimizing contamination.


Pulsatile Drug Delivery System: An Approach for Attaining Time Programmed Release

About Authors:
Pratapwar A.S1*, Agrawal V.A2
S.N.Institute of Pharmacy Pusad, Yewatmal
Corresponding Author: Agrawal V.A
vijayagrawal499@gmail.com

Abstract:
Out of all the routs of drug administration oral is the most convenient and better for self administration from the patient point of view and suitable for the release controlled delivery systems from the formulators view. In the today’s field of modern drug therapy much more attention is given on the development of oral release modified delivery systems such as programmed release, gastro retentive, floating and most important pulsatile or time programmed release systems. The chronotherapeutic drug delivery systems are designed to maintain the adequate drug concentration according to the needs of the physiological states of patient’s body and the cardian rhythm. Pulsatile release systems are designed to deliver the drug at the right site, at right time and in right concentration after a predetermined lag time. To achieve the desired pulse release pattern, many technological approaches have been investigated like Single unit system,Tablet-Time clocks system, Capsule- Pulsincap system and multiple unit system, Pellets,Time controlled explosion system,Multi-layered Tablet,Chemical stimuli induced pulsatile systems like Glucose-responsive insulin release devices, Inflammation-induced release, intelligent gels responding to antibody concentration, release control by use of the soluble, rupturable, swelling and erodible polymers in the formulation. The present article focus on the basics of chronotherapeutic drug delivery systems, diseases with cardian rethyms, need, advantages, types and approaches for the development of Pulsatile drug delivery systems.


DISCUSSION ON NOVEL RECTAL DRUG DELIVERY SYSTEMS –A RECENT REVIEW

About Authors:
Anil kumar vadda1, Lohithasu Duppala2
1AVANTHI Institute of pharmaceutical sciences, pharmacology,
2GITAM Institute of Pharmacy, GITAM University, Pharmaceutics,
visakhapatnam, Andhra Pradesh, India-530045
2lohithasu@gmail.com, 1anilkumar.vadda@gmail.com

ABSTRACT:
Rectal drug delivery is an efficient alternate to oral and parenteral route of administration in partial avoidance of first pass metabolism and protein peptide drug delivery. This route allows both local and systemic therapy of drugs. Controlled absorption enhancement of drugs can be achieved by the rectal route because of the constant conditions in the rectal environment. In the present review presents various dosage forms used in rectal route, factors related recatal route of absorption ,fate of drug  absorption. This review also presents polymers in rectal route of drug delivery.


FORMULATION AND EVALUATION OF DRY POWDER INHALERS OF BUDESONIDE FOR PULMONARY DELIVERY

About Authors:
Neethu.R.R
Uthradam
Kannayamkodu
Chenkikunnu
Kilimanoor.P.O, Trivandrum dist, Kerala 695601
neethalekshmi87@gmail.com

Abstract:
Budesonide is a corticosteroid, used in the treatment of inflammatory conditions such as asthma and COPD. The present study was undertaken with the aim to formulate and evaluate dry powder inhalers of Budesonide for pulmonary delivery. Dry powder inhalers of Budesonide were prepared using different concentrations of fine lactose and magnesium stearate by Geometric dilution method. The drug-carrrier compatibility study was carried out by FT-IR studies. A total of eleven batches were formulated and evaluated for physical appearance, average fill weight, flow properties, particle size analysis, content uniformity, moisture content and assay. In-vitro drug deposition studies were carried out by using Modified Twin Stage Impinger (TSI) apparatus. Of all eleven batches, the formulation F4, comprising of fine lactose 30% was found to be the best having comparatively higher fine particle fraction (FPF) of 25.32%. The result indicated that the amount of drug that reaches in the lung was higher for formulation F4. Further invivo safety and deposition studies on suitable animal models and human volunteers will give better insight for clinical applications of the Budesonide DPI.


A REVIEW ON: FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET

About Authors:
Nishtha Tiwari
Department of pharmacy,
b.u Bhopal (m.p.), India
Nishthatiwari.18@gmail.com

ABSTRACT
The oral route of drug administration is the most important method for administering drugs for systemic effects. Except in certain cases the parenteral route is not routinely used for self administration, e.g. insulin. The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects. The parenteral route of administration is important in treating medical emergencies in which the subject is comatose or cannot swallow. Nevertheless it is probable that at least 90% of all drugs used to provide systemic effects are administered by the oral route.


Pages

 

FIND MORE ARTICLES