Pharmaceutics Articles

DISCUSSION ON NOVEL RECTAL DRUG DELIVERY SYSTEMS –A RECENT REVIEW

About Authors:
Anil kumar vadda1, Lohithasu Duppala2
1AVANTHI Institute of pharmaceutical sciences, pharmacology,
2GITAM Institute of Pharmacy, GITAM University, Pharmaceutics,
visakhapatnam, Andhra Pradesh, India-530045
2lohithasu@gmail.com, 1anilkumar.vadda@gmail.com

ABSTRACT:
Rectal drug delivery is an efficient alternate to oral and parenteral route of administration in partial avoidance of first pass metabolism and protein peptide drug delivery. This route allows both local and systemic therapy of drugs. Controlled absorption enhancement of drugs can be achieved by the rectal route because of the constant conditions in the rectal environment. In the present review presents various dosage forms used in rectal route, factors related recatal route of absorption ,fate of drug  absorption. This review also presents polymers in rectal route of drug delivery.


FORMULATION AND EVALUATION OF DRY POWDER INHALERS OF BUDESONIDE FOR PULMONARY DELIVERY

About Authors:
Neethu.R.R
Uthradam
Kannayamkodu
Chenkikunnu
Kilimanoor.P.O, Trivandrum dist, Kerala 695601
neethalekshmi87@gmail.com

Abstract:
Budesonide is a corticosteroid, used in the treatment of inflammatory conditions such as asthma and COPD. The present study was undertaken with the aim to formulate and evaluate dry powder inhalers of Budesonide for pulmonary delivery. Dry powder inhalers of Budesonide were prepared using different concentrations of fine lactose and magnesium stearate by Geometric dilution method. The drug-carrrier compatibility study was carried out by FT-IR studies. A total of eleven batches were formulated and evaluated for physical appearance, average fill weight, flow properties, particle size analysis, content uniformity, moisture content and assay. In-vitro drug deposition studies were carried out by using Modified Twin Stage Impinger (TSI) apparatus. Of all eleven batches, the formulation F4, comprising of fine lactose 30% was found to be the best having comparatively higher fine particle fraction (FPF) of 25.32%. The result indicated that the amount of drug that reaches in the lung was higher for formulation F4. Further invivo safety and deposition studies on suitable animal models and human volunteers will give better insight for clinical applications of the Budesonide DPI.


A REVIEW ON: FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET

About Authors:
Nishtha Tiwari
Department of pharmacy,
b.u Bhopal (m.p.), India
Nishthatiwari.18@gmail.com

ABSTRACT
The oral route of drug administration is the most important method for administering drugs for systemic effects. Except in certain cases the parenteral route is not routinely used for self administration, e.g. insulin. The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects. The parenteral route of administration is important in treating medical emergencies in which the subject is comatose or cannot swallow. Nevertheless it is probable that at least 90% of all drugs used to provide systemic effects are administered by the oral route.


INSIGNIFICANT EFFECT OF SUPERPOROUS HYDROGEL PARTICLES AS A SUPERDISINTEGRANTS IN FAST DISPERSIBLE TABLETS OF ACECLOFENAC

About Authors:
Dr. HV Chavda1*, Ms. SK Patel1,
Dr. CN Patel1,
1Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat-384001, India.
*hvchavda@sspcmsn.org

ABSTRACT
Background:
In present investigation an attempt has been made to formulate a fast dispersible formulation of aceclofenac using three different superdisintegrants. The role of superporous hydrogel particle as a superdisintegrant was checked for its further future applications. Materials and Methods: The selection of superdisintegrants viz. poly (Acrylamide-co-Acrylic acid) superporous hydrogel particles, cross carmellose sodium and starch 1500 were done using the simplex lattice design. Tablet formulations were prepared using direct compression technique and evaluated for hardness, weight variation, friability, drug content, dispersion time, wetting time, water absorption ratio and in vitro drug release studies. Results and Discussion: The dispersion time of all formulation showed less than 21 second. Superporous hydrogel particles did not showed significant improvement in dispersion time compared cross carmellose sodium and starch 1500. The in vitro drug release from batch F7, tablets containing equal proportions of superdisintegrants showed fast dispersion and fast release compared to other batches. Batch F7 was stable for the period of six months at 40 oC / 75 %RH. Conclusions: Combination of three superdisintegrants was more suitable in fast dispersible tablet formulation of aceclofenac. The superporous hydrogel particles showed equivalent effect as a superdisintegrant, however process complexity of its preparation suspects its role or an option as a superdisintegrant in fast dispersible or immediate release formulations.


BUCCAL DRUG DELIVERY SYSTEM

About Author:
Prathipati padmaja
vathsalya college of pharmacy, JNTU
prathipatipadmaja@gmail.com

INTRODUCTION
Buccal drug delivery was introduced by Orabase1 in 1947, when gum tragacanth was mixed with dental adhesive powder to supply penicillin to the oral mucosa (Sudhakar et al., 2006). In recent years, delivery of therapeutic agents through various transmucosal routes has gained significant attention.
Buccal delivery of drugs provides an attractive alternative to the oral route of drug administration, particularly in overcoming deficiencies associated with the latter mode of dosing.  Buccal mucosa consist of stratified squamous epithelium supported by a connective tissue lamina propia (Squire and Wertz, 1996) was investigated as a site for drug delivery several decades ago and the interest in this area for the trasmucosal drug administration is still growing.



MAGNETIC MICROSPHERE

About Author:
Dipak Kumar Dash
M Pharm pharmaceutics
Production officer -Akorn india pvt ltd
dipak.dipak.dash@gmail.com

INTRODUCTION
Introduction In recent years, polymeric controlled drug delivery systems have evolved as one of the most attractive areas in drug delivery research. The drug release is controlled by properties of the polymer-drug system and also by other factors like pH, enzymes etc. Despite several advantages offered by the controlled drug release, one important problem pertinent to the entire field is that all the systems so far developed give release rates that are constant or decrease with time.Increased delivery on demand will be very beneficial in situations like, delivery of insulin for patients with diabetes mellitus, antiarrythmics in case of heart disorders and nitrates in case of angina pectoris. This increased delivery on demand can be achieved by using external feed back control systems such as magnetic control. The concept of magnetically controlled drug delivery for the first time was proposed be Tyle in 1988. A system has been developed to magnetize the carriers so that these particles can be retained on the target site by the application of an external magnetic field of appropriate strength. Magnetic fields are believed to be harmless to biological systems and adaptable to any part of the body.


ENHANCEMENT OF DISSOLUTION RATE OF CEFIXIME TRIHYDRATE BY USING VARIOUS SOLID DISPERSION TECHNIQUES

About Authors:
Narasimha Murthy Yedulapurapu*, Babu Rao. Chandu
Donbosco P.G. College of Pharmacy, 5th mile,
Pulladigunta, Kornepadu (V), vatticherukuru (M),
Guntur, Pin code: 522017, Andhra Pradesh.
*Murthyvedulapurapu@gmail.com

ABSTRACT:
Cefixime Trihydrate is an orally active third generation cephalosporin. It has plasma half-life of 3-4hrs; it is active against Gram+ve as well as Gram-ve bacteria. The present investigation involves the enhancement of dissolution rate of cefixime by using various solid dispersion techniques with a view to prolong the drug release in the gastrointestinal tract and consequently into the plasma. The solid dispersions were formulated by using the Croscarmelose sodium as a disintegrant. The solid dispersions were prepared by solvent evaporation, kneading, Physical mixing, Co-grinding techniques. In solvent evaporation technique, Dichloromethane is used as a solvent and in kneading technique water is used as solvent. The prepared solid dispersions were evaluated for in-vitro dissolution studies. Among the 5 formulations F5 sows the good results.


NANOTECHNOLOGY FOR DRUG DELIVERY SYSTEM

About Author:
Kambham venkateswarlu
graduate student
Sri lakshmi narasimha college of pharmacy,
palluru, chittor-517132, andhra pradesh, india
k.v.reddy9441701016@gmail.com

ABSTRACT:
Nanotechnology is the technology of nanoparticles which are made of polymers of synthetic or natural origin. Nanoparticle is a collective name for nanospheres and nanocapsules of size from 10-1000nm. Nanocapsules are vesicular systems in which drug is confined to a cavity surrounded by a unique polymer membrane. Nanospheres are matrix systems in the drug are physically and uniformly dispersed. Nanotechnology is the design, characterization, production on and application of structures, devices and systems by controlling shape and size on the nanoscale. Nanotechnology in medicine is referred to as nanomedicine and involves the implementation of technologies that exist or function at the cellular and levels medical use.


INDIAN DRUG REGULATORY SYSTEM: MOVING TO A NEW ERA

About Author:
Priyank Sharma
M. Pharm, Drug Regulatory Affairs
Jaipur National University
Jaipur, Rajasthan
Priyank2k4urwith@gmail.com

Abstract:
The Pharmaceutical industry represents one of the India’s strength.  The regulation of pharmaceuticals in India is generally seen to be in need of reform, and has been the subject of many official commissions since 1995. Most commentators agree that the state should intervene to prevent untrammeled market forces leading to citizens’ suffering, because adequate information about the costs and benefits of different pharmaceuticals is inaccessible to most users. But in India, a wide range of stakeholders must be considered before changes can be made to the regulatory framework.


FORMULATION AND CHARACTERIZATION OF THEOPHYLLINE MICROSPHERE

About Authors:
Sofiya Verma*, Dipak V, Ashok A, Neha C, Jagruti R, Ashutosh. M
Shri ram institute of pharmacy
Jabalpur M.P
*sofiyavermamph@gmail.com

ABSTRACT:
The purpose of this research was to prepare and characterize theophylline microsphere of guar gum polymer for the application of nocturnal asthma. The microsphere were prepared by using emulsification method using sodium borate as a cross linking agent and coating was done by solvent evaporation method with the pH sensitive eudragit S-100 polymers. The prepared microsphere were white, free flowing and spherical in shape. The drug-loaded microsphere showed entrapment efficiency and   drug release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs and XRD spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The prepared theopylline microsphere has the potential for delaying the release of drug.


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