You are hereSynthesis and characterization of gelatin nanoparticle from fish and it role as drug delivery vehicle for Tuberculosis

Synthesis and characterization of gelatin nanoparticle from fish and it role as drug delivery vehicle for Tuberculosis


About Authors:
L.Kalaiselvi1*, Mr.R.Ulaganathan2
1
B.Pharm, II M.Tech Nanoscience&Technology,
2
Assistant Professor,
B.Sc, M.Sc., M.Tech
Department of Biotechnology, Udaya school of Engineering,
Nagercoil, Kanyakumari dt.
*klkselvi@gmail.com

ABSTRACT:
Nanoparticle based systems have significant prospective for diagnosis, treatment and prevention of tuberculosis (TB) Gelatin nanoparticle derived from marine sources (fish skin, bone and fins) has been looked upon as a possible alternative to bovine and porcine. Fish gelatin nanoparticle synthesis by two step desolvation method, it was stable nanoparticles and confirm through Scanning electron microscopy (SEM).These nanoparticle were used as carrier for rifampicin. Our aim to develop a Nano particulate carrier of rifampicin for controlled delivery as well as reduced toxicity. In this study, rifampicin loaded fish gelatin nanoparticle was fabricated by an absorption/adsorption method. The effect of several variables on the Nanoparticle’s characteristics was calculated.

Reference Id: PHARMATUTOR-ART-1351

1. INTRODUCTION
Nanotechnology can be defined as the science and engineering involved in the design, Synthesis, characterization, application materials and devices whose smallest functional organization in at least one dimension is on the nanometer scale (One billionth a meter). It can prove to be a boon for human healthcare. Because Nano science and nanotechnologies have a huge potential to bring benefits in areas as diverse as drug development, water decontamination, information and communication technologies and the production of stronger, lighter materials. Human health care nanotechnology research can definitely result in immense health benefits. The genesis it nanotechnology can be traced to the promise of revolutionary advances across medicine, communications, genomics, and robotics. A complete list the potential applications nanotechnology is too vast and diverse to discuss in detail, but without doubt, one the greatest values nanotech will be in the development of new and effective medical treatments.

1.1.1 APPLICATION OF NANOTECHNOLOGY:
Nanotechnology in drug delivery from nanotechnology there is only one step Nano medicine, which may be defined as the monitoring, repair, Construction, and control of human biological systems at the molecular level, using engineer’s Nano devices and nanostructures. If can also be regarded as another implementation if nanotechnology in the field if medical science and diagnostics. One of the most important issues is the proper distribution of drugs and other therapeutic agents with in the patient’s body. During the past two decades, however, researchers involved in the development of pharmaceuticals have understood that drug delivery is a fundamental part of drug development, and a wide range of drug delivery systems has thus been designed. Ideally all these systems would improve the stability, absorption, and therapeutic concentration if the drug with in the target issue, as well as permit reproducible and longtime release if the drug at the target site.

1.1.2 THE NEED FOR INNOVATIVE NANOTECHNOLOGY BELOW DRUG TARGETING
Research into the delivery and targeting if therapeutic and diagnostic agents with nanoparticles is at the forefront, if Nano medicine for several reasons. First traditional oral or inject able drugs are not necessarily the most efficient formulations for a given product. This is particularly true for new biologics such as proteins and nucleic acids that require novel delivery technologies to optimize efficacy, minimize side effects and lead to better patient compliance.

Since the efficiency related to particle size nanoparticle formulations can enhance bioavailability, improve times/ controlled release of drugs and enable none precise targeting to the level of direct intracellular delivery. Because of their small size, Nano particulate drug carriers by pass the blood brain barrier, the branching pathways of the pulmonary system, and the tight epithelial junctions if the skin that normally delivery if drugs to the designed target. These reformulation drugs have the potential advantages of drug side effects, increasing patient compliance, and reducing health care costs. The current strategy for enhancing the therapeutic activity if currently available drugs is to entrap drugs with in a delivery system from where they are slowly released over an external time period. A novel drug carrier system plays an important role in controlled delivery as a pharmaceutical agent to the target at therapeutically optimal rate and dose. Several reports are available regarding the use of carrier systems like liposomes, dendrimers, micro spheres, and solid, lipid Nano particles for delivery of bio actives. Amongst various drug delivery systems, Nano particles NP represent a very promising approach for deliver bio actives.

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