July 2012

About Authors:
Chauhan M.K., Kawadkar J., Kishore R.^*, Pathak A.M.
Department of Pharmaceutics
DIPSAR, New Delhi
*rajkishor.aryan@gmail.com

ABSTRACT
This paper discussed the problems associated with nasal drug delivery and how it is possible, sometimes by means of quite simple concepts, to improve transport across the nasal membrane. It also described the advantages, barriers, physicochemical factors, and formulation related parameters that affecting the nasal drug delivery and the applications of nasal route for delivery of peptides, proteins, non-peptide drugs, and vaccines.  In this way it is feasible to deliver efficiently challenging drugs such as small polar molecules, peptides and proteins and even the large proteins and polysaccharides used in vaccines or DNA plasmids exploited for DNA vaccines. The transport of drugs from the nasal cavity directly to the brain is also described. Nasal vaccines offer several benefits, such as low enzymatic degradation compared to oral vaccines, and greater acceptability to patients. Nasal vaccines, however, have to overcome several limitations, including mucociliary clearance. Therefore, nasal vaccines require potent adjuvants and delivery systems to enhance their immunogenicity and to protect their antigens.

Sinhgad Institute Of Pharmaceutical Sciences is affiliated to University of Pune and approved by All India Council for Technical Education, Pharmacy Council of India, Director of Technical Education, Mumbai, Maharashtra State. It offers undergraduate and postgraduate courses in Pharmacy.

Post: Professor, Associate Professor, Assistant Professor

The Department of Biotechnology (DBT), Govt. of India has initiated a multi-institutional partnership program on biodesign called the National Bio design Alliance Programme between Translational Health Science & Technology Institute (THSTI), Regional Centre for Biotechnology (RCB), International Centre for Genetic Engineering and Biotechnology ( ICGEB), All India Institute of Medical Sciences (AIIMS), Indian Institute of Technology (IIT) Delhi and Christian Medical College (CMC) Vellore.

Abbott India Limited is a subsidiary of Abbott Laboratories, USA, a global, iversified health care company devoted to the discovery, development, manufacture and marketing of pharmaceutical, diagnostic, nutritional and hospital products. The company now employs approximately 70,000 people and markets its products in 130 countries worldwide.

Religare Wellness (formerly, Fortis Healthworld) is a pioneering endeavor within India’s healthcare industry putting health solutions on the retail map. As a part of the vision of Fortis Healthcare and Religare Enterprises, Religare Wellness incorporates setting up of a Pan India World Class Retail Network of health stores that would provide comprehensive solutions under one roof.

National Institute of Malaria Research (NIMR) was established in 1977 as 'Malaria Research Centre', which was renamed as 'National Institute of Malaria Research' in November 2005. NIMR is one of the institutes of the Indian Council of Medical Research (an autonomous body under Department of Health Research, Ministry of Health & Family Welfare, Govt. of India).

About Author:
Mr. Jagmohan Rai Agarwal,
M.Pharm (1968), Industrial experience SSI sector, nearly 37 years,
retired from own Industry (2004),
Founder President of M.P.Pharmacy Graduates’ Association (MPGA),
Ex President: M.P.Pharmaceutical Manufacturers’ Organisation (MPPMO),
Founder President : M.P. Small Scale Drug Manufacturers’ Association (MPSDMA),
Ex President Indian Pharmaceutical Association, M.P. State Branch, Indore (IPA),
Ex Vice Chairman Confederation of Indian Pharmaceutical Industries (SSI) (CIPI)
Recently submitted thesis for award of  Ph.D. on title “Enforcement of Drug Laws-Globalization vis-à-vis Indian Drug Laws”
(Email: sharda_jollo@yahoo.co.in)

Macleods has its presence in over 30 countries with more than 300 registrations.