• PharmaTutor
    27 March 2012

    Formulation and In-vitro characterization of Gelatin Micro spheres loaded with Lisinopril dihydrate

    ABOUT AUTHORS:
    Sudha Talasila*1, Yamini Pendyala2, Deepthi Madhu3, Dr.K.L.Senthil kumar.
    1,2 Department of Pharmaceutics,
    Padmavathi College of Pharmacy and Reserch institute,
    periyanahalli, Tamilnadu, India.
    3 Department of Pharmaceutics, Gitams university,
    Visakhapatnam, India.

    ABSTRACT
    Aim of our present study was to formulate the Gelatin Microspheres Loaded with Lisinopril Dihydrate by using Co-acervation phase separation technique for control prolonged release of drug. Micro-particulate drug delivery of Lisinopril Dihydrate was prepared by using a blend of gelatin-carbopol 934P NF and Gelatin-Sodium alginate as release retardant.Lisinopril Dihydrate Microspheres were formulated by using different drug, gelatin-carbopol and gelatin-sodiumalginate in 6 batches was F1, F2, F3, F4, F5 & F6. All the formulations were investigated for various evaluation parameters like particle size, Bulk density, flow behavior, Entrapment efficiency, percentage yield and in vitro drug release etc. All the formulations showed good flow behavior. SEM study revealed that the spheres were almost spherical in shape with smooth surface. In-vitro drug release study showed that by increasing the polymer concentration the drug release of all the formulations were gradually decreased and the optimized formulation (F6) was able to sustain the drug release for 24 hours. So, it was concluded that gelatin microspheres loaded with Lisinopril Dihydrate can be prepared by Coacervation phase seperation  technique and used for sustaining the drug release for prolonged period of time.

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    Opening for Manager-Scientific Affairs at Venus Remedies

  • A REVIEW ON FORMULATION AND EVALUATION ASPECTS OF ENTERIC COATED PELLETS
    26 March 2012
    A REVIEW ON FORMULATION AND EVALUATION ASPECTS OF ENTERIC COATED PELLETS

    About Authors:
    Kapil Sharma*, Priyanka Sharma**
    *M.Pharm, Yaresun Pharmaceutical Pvt Ltd, India
    **M.Sc, Yaresun Pharmaceutical Pvt Ltd,
    Rajasthan, India.

    1.PELLETS
    Pellets are spheres of varying diameter depending on the application and the wish of the producer. Applications are found not only in the pharmaceutical industry but also in the agribusiness (e.g., fertilizer, fish food) and in the polymer industry.
    In the pharmaceutical industry, Pellets can be defined as small, free-flowing, spherical particulates manufactured by the agglomeration of fine powders or granules of drug substances and excipients using appropriate processing equipment. The term also has been used to describe small rods with aspect ratios of close to unity.

  • A REVIEW ARTICLE ON RESEARCH & DEVELOPMENT OF PHARMACEUTICAL MEDICINE WITH SPECIAL EMPHASIS ON PREFORMULATION (A NEED FOR DOSAGE FORM DESIGN)
    23 March 2012
    A REVIEW ARTICLE ON RESEARCH & DEVELOPMENT OF PHARMACEUTICAL MEDICINE WITH SPECIAL EMPHASIS ON PREFORMULATION (A NEED FOR DOSAGE FORM DESIGN)

    About Authors:
    Kapil Sharma*, Priyanka Sharma**
    *M.Pharm, Yaresun Pharmaceutical Pvt Ltd, India
    **M.sc, Yaresun Pharmaceutical Pvt Ltd,
    Rajasthan, India.

    Aim: - To search Pharmaceutical medicine (New, Safe & Effective) to enhance health and benefits of patients & community.

    Trends:-Usually search a pharmaceutical medicine is starting from “Drug Discovery and Drug Development” (D4) or Pharmaceutical R&D.
    D4 is very long, very costly and very complex process, so mostly companies put together D4 plan. Drug Discovery and Drug Development is the treds of searching a Pharmaceutical medicine

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    Walk in interview for post of SRF in National Institute for Research in Reproductive Health

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  • Walk in Interview in Indian Institute of Technology for position of Jr. Research Fellow
    20 March 2012
    Walk in Interview in Indian Institute of Technology for position of Jr. Research Fellow

    Indian Institute of Technology Roorkee, Roorkee invites the applications on the prescribed form for the following posts as per details given against each. The application form and general conditions may be obtained from Superintendent, Establishment ‘B’ Section, IIT Roorkee.

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    18 March 2012
    Require Fresh & Exp. B.Pharm and M.Sc, Ph.D, MBBS, MVSc as Scientists in B to H at NATIONAL INSTITUTE OF ANIMAL BIOTECHNOLOGY (NIAB), Government of India | Total 12 posts

  • Work in J. Mitra Pharma | AM-HR, Trainee QA Officer, QA Executive, Research Associate, Manager Customer Service, ASM, Product Executive, Asst. Manager- QA
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    Work in J. Mitra Pharma | AM-HR, Trainee QA Officer, QA Executive, Research Associate, Manager Customer Service, ASM, Product Executive, Asst. Manager- QA

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  • VALIDATED RP – HPLC METHOD FOR DETERMINATION OF MONTELUKAST SODIUM AND LEVOCETIRIZINE IN BULK AND ITS PHARMACEUTICAL FORMULATIONS USING UV-VIS DETECTOR
    18 March 2012
    VALIDATED RP – HPLC METHOD FOR DETERMINATION OF MONTELUKAST SODIUM AND LEVOCETIRIZINE IN BULK AND ITS PHARMACEUTICAL FORMULATIONS USING UV-VIS DETECTOR

    About Authors:
    RAVISANKAR.M*1, SUBASINI.U2, ANAND THANGADHURAI.S3, KARTHIKEYAN.S4, CHANDRA SEKAR.E.5
    1.Swamy Vivekanandha College of pharmacy, dept of pharmaceutical analysis. Thiruchengode
    2.Swamy Vivekanandha College of pharmacy, dept of pharmacognosy. Thiruchengode
    3.Swamy Vivekanandha College of pharmacy, dept of pharmaceutical analysis. Thiruchengode
    4.Kausikh therapeutics and private limited.chennai
    5.Swamy Vivekanandha College of pharmacy, dept of pharmaceutical analysis. Thiruchengode

    ABSTRACT
    An isocratic reverse phase high performance liquid chromatographic method for estimation of montelukast sodium and levocetirizine in bulk dosage and in marketed formulations has been devised and validated. The chromatographic separation achieved on shodex c18-4E column (5µm, 250 mm x 4.6 mm) and  acetonitrile: methanol: ammonium acetate buffer (PH- 5.5) in the ratio of 25:55:20 v/v. The flow rate was 1.0 ml/min and the UV detection was identified at 225nm.The retention times for montelukast sodium and levocetirizine was found to be 5.15 min and 3.12 min respectively. The linearity of montelukast sodium and levocetirizine is 10 -50µg/ml with the correlation co efficient 0.99 respectively. The validation parameters such as accuracy, precision, LOD, LOQ, Robustness, ruggedness were performed as per ICH guidelines. This method can be used for routine analysis of montelukast sodium and levocetirizine in bulk and marketed dosage forms.

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