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  • Career for pharma background candidates as Vaccine & Logistics Manager at JRHMS

    The National Health Mission (NHM) was launched with a view to bring about dramatic improvements to the health system and health status of people, especially those who live in the rural areas of the country. The Mission seeks to provide universal access to equitable, affordable and quality health care which is accountable at the same time responsive to the needs of the people, reduction of child and maternal deaths as well as population stabilization, gender and demographic balance. In this process, the Mission helps achieve goals set under the National Health Policy and the Millennium Development Goals.

  • FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS TO ENHANCE DISSOLUTION RATE OF LAMOTRIGINE BY USING SOLID DISPERSION TECHNIQUE

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS
    Bhumi B. Patel1*, Chainesh N. Shah2, Rumit M. Shah3
    1Department of Pharmaceutics, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Gujarat, India.
    2 Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Gujarat, India
    3 Department of Pharmacognosy, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Gujarat, India.
    * patelbhumi198@gmail.com

    ABSTRACT
    Lamotrigine belongs to biopharmaceu­tical classification systems; BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action. Hence, the main objective of this study is to improve the solubility by solid dispersion technique and formulate it as Orodispersible tablets to avert the problems of swallowing and to provide rapid onset of action. Lamotrigine solid dispersion was prepared by using PEG 6000 as solubility enhancers and formulated it into ODT by direct compres­sion technique using different concentrations of Sodium Starch Glycolate, Cross Carmalose Sodium, and Kyron T-314 as cross linked polymers. The tablets were evaluated for various parameters and the results were found to be sat­isfactory. The batches batch containing Kyron T-314 as super disintegrant in 7% concentration, as they showed 95.75% drug release in 15 minutes with a disintegration time of 11 seconds which shows improved dissolution rate in compare to marketed formulation of Lamotrigine.

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