Telangana

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF FLOATING TABLETS OF CEFIXIME

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ABOUT AUTHORS:
B.Venkateswara Reddy
Department of Pharmaceutics,
St.Pauls College of Pharmacy, Turkayamjal (V),
Hayathnagar (M), R.R.Dist-501510, India.
basu.pharmacist@gmail.com

ABSTRACT:
Objective:
Cefixime is a third generation cephalosporin antibiotic having bactericidal activity by inhibition of cell wall synthesis and is used in the treatment of uncomplicated UTI, pharyngitis and tonsillitis, acute bronchitis and acute exacerbation of chronic bronchitis, uncomplicated gonorrhoea etc. The concept of formulating floating tablets containing Cefixime offers a suitable and practical approach in serving desired objective of retaining the drug in the stomach to increase the its bioavailability.
Methods:
The tablets were prepared by direct compression methodand total of 12 formulations are developedemploying HPMC K100M and HPMC K15M as polymers for sustaining the drug release and sodium bicarbonate as the gas generating agent.
Results:
Various polymers have been selected and subjected to IR-spectroscopic studies and found that there were no drug–excipient interactions. The powder blends of all the formulations have shown good flow properties. Other parameters such as hardness, friability, drug content uniformity, Floating lag time and in-vitro dissolution studies were performed and the results were satisfactory.
Conclusion:
Formulation F 12 was found to be best in all aspects and was considered as optimized formulation, it has a low floating lag time of  2mins  and has shown a maximum drug release of 99% at the end of 24 hours and drug release was by diffusion through the polymer matrix.

NIPER invites Assistant Professor, Professor, Associate Professor

National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad (Established in the year 2007) is a prestigious educational institution of national importance under the aegis of Dept, of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Government of India. NIPER, Hyderabad conducts courses in MS (Pharm), M.Tech (Pharm) in Pharmaceutical Sciences and MBA (Pharm) in Pharma Management for Two years. Students are selected through a national entrance test. Research opportunities also exist for those who would like to pursue their Doctoral Degree. The Institute is mentored by CSIR-Indian Institute of Chemical Technology, Hyderabad a leader in Chemical Technology well known all over the world.

NIPER is now inviting applications for faculty and other position on contractual basis intially for a period of one year which is likely to continue based on the performance of the selected candidate. Candidates will be paid handsome consolidated emoluments.

Post: Assistant Professor, Professor, Associate Professor

Work as Regional Sales Managers in Agama Enterprises | 4 Posts

Agama is a leading player in healthcare solutions known for its knowledge based complete solutions, latest in technology and creative marketing practices in the Healthcare segment.
Andersen Group, USA operates globally in more than 80 countries thru joint ventures and subsidiary companies. Andersen products are leaders in Healthcare products and services, Sterilization equipments and allied products . Indian Operations of Andersen has completed 15 years and is controlled by a Joint Venture under Agama.

Post: Regional Sales Managers

Walk in interview for Project Assistants, Project Technician in NIN

Eligible candidates are invited to apply for the following posts on the ad hoc research projects mentioned in the column no.VII at this Institute.

The Applications will be received from the individuals on 21st July, between 9:30 A.M. and 10:00 A.M. at Conference Hall, NIN, Tarnaka, Hyderabad. Late applications will not be entertained after 10:00 A.M. at any circumstances. The Candidates may download the Application form from NIN website: www.ninindia.org

Post: Project Assistant, Project Technician

Career @ National Institute of Pharmaceutical Education and Research in topical formulation

NIPER, Hyderabad is an autonomous body which has been established under the aegis of the Ministry of Chemicals and Fertilizers, Government of India, to provide leadership in Pharmaceutical Sciences and other related areas. The Indian Institute of Chemical Technology, Hyderabad as Mentor Institute is inviting applications for the following position for NIPER, Hyderabad:

Post: Senior Research Fellow

Zydus Hospira Oncology looking for Officer / Executive, Sr. Executive / Dy. Manager | Walk in

Zydus Hospira Oncology Private Limited, located in Pharmez (SEZ), Near Village Matoda in Ahmedabad is a 50-50 % joint venture (JV) company between Cadila Healthcare Limited (Zydus Cadila), India and Hospira Inc. USA. Zydus Hospira is engaged in the business of manufacturing and selling cytotoxic injectable products (Finished Products) to nearly 60 countries including USA.
It has received approvals from global regulatory bodies like the USFDA, MHRA, TGA and so on.

We are looking lor achievement oriented and enthusiastic professionals In the following positions

Post: Officer / Executive, Sr. Executive / Dy. Manager

Opportunity for the post of Directors in National Institutes of Pharmaceutical Education and Research

National Institutes of Pharmaceutical Education and Research (NIPERs)under the aegis of Ministry of Chemicals and Fertilizers, Department of Pharmaceuticals are institutes of National importance created by an Act of Parliament with a mandate to nurture and promote quality and excellence in pharmaceutical education and research as to create human resources of a higher caliber for the Indian pharmaceutical industry, towards making India a global leader in innovation and Drug Discovery while continue to offer leadership in formulations. The NIPERs- Guwahati, Hajipur, Hyderabad& Raebareli are set up during 2007-08 and are functioning under premier mentor institutions and are being developed as independent institutions soon. The NIPER Mohali is having its own campus. Now applications are invited for the post of Director of these NIPERs.

Post: Directors of NIPERs –Mohali, Guwahati, Hajipur, Hyderabad and Raebareli.

Required for Manager, Quality Assurance in Nektar

Nektar Therapeutics is a clinical-stage biopharmaceutical company developing a pipeline of drug candidates that utilize its PEGylation and polymer conjugate technology platforms, which are designed to improve the benefits of drugs for patients. Its product pipeline consists of drug candidates across a number of therapeutic areas, including oncology, pain, anti-infectives, anti-viral and immunology. Nektar's research and development activities involve small molecule drugs, peptides and other potential biologic drug candidates. Its drug candidates are designed to improve the pharmacokinetics, pharmacodynamics, half-life, bioavailability, metabolism or distribution of drugs and improve the overall benefits and use of a drug for the patient.

Post: Manager, Quality Assurance (India)

A REVIEW ON ACRIDONE DERIVATIVES AND ITS IMPORTANCE

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ABOUT AUTHORS:
Vishwanadham Yerragunta*, E.Sathish Reddy, M.Kishore, Hari Om Prakash rao, Ayesha Sadia, Ayesha Saba, Syeda Kausar Fatima
Department of Pharmaceutical Chemistry, Prathap Narendar Reddy College of Pharmacy,
Pedda shapur, Shamshabad, Hyderabad, Telangana.
vishwanadham.y@gmail.com

ABSTRACT:
Acridoneis an organic compound containing a carbonyl group attached to the 9 position. It may be synthesized by the self-condensation of N-phenylanthranilic acidAcridone and its derivatives can be synthesized by a number of methods such as Ullmann condensation, by benzyne mechanism, by radical reaction of quinines etc. acridone nucleus due to its variety of pharmacological activities. These pharmacological activities include anticancer, antimicrobial, antiviral, antimalarial and anti-inflammatory activities. This review article literature survey summerizes the synthesis and pharmacological activities of acridone and its derivatives.

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